A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioacti...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/76986/ http://irep.iium.edu.my/76986/1/Abstract.pdf http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf |
| Summary: | Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioactive compound. Material and methods: Successive soxhlet extraction was conducted using n-hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum’s extract. Results: The DCM extract of stem bark (DS) was the most
potent extract followed by n-hexane extract of the
stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 μg/mL to 6.25 μg/mL, against S. epidermidis, MRSA and S. aureus. Conclusion: S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA. |
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