Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines

Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic...

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Main Authors:	Meenakshi Sundram, Tamil Chelvan, Zakaria, Mohd Hazim, Mohd Nasir, Mohd Hamzah
Format:	Article
Language:	English
Published:	Zibeline International Publishing Sdn. Bhd. 2019
Subjects:	QH301 Biology
Online Access:	http://irep.iium.edu.my/76737/ http://irep.iium.edu.my/76737/ http://irep.iium.edu.my/76737/ http://irep.iium.edu.my/76737/1/2gws2019-10-14.pdf

id	iium-76737
recordtype	eprints
spelling	iium-767372019-12-27T02:32:21Z http://irep.iium.edu.my/76737/ Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines Meenakshi Sundram, Tamil Chelvan Zakaria, Mohd Hazim Mohd Nasir, Mohd Hamzah QH301 Biology Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic activity of C. mangga and B. rotunda ethanolic extracts. Initially, in this study, ethanolic extracts from rhizomes of C. mangga and B. rotunda were obtained through Soxhlet extraction method. 12.6% and 3.5% of crude extract were obtained from C. mangga and B. rotunda respectively. For MTT assay, the IC50 values are 207µg/ml and 31.96 µg/ml for C. mangga and B. rotunda respectively. Meanwhile for the antioxidant activity using DPPH assay, C. mangga showed higher antioxidant activity with IC50 values of 1073µg/ml compared to B. rotunda with IC50 values of 578µg/ml. It can be concluded both extracts showed low inhibitory effect on MCF-7 cancer cells growth and DPPH free radical activity. Zibeline International Publishing Sdn. Bhd. 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/76737/1/2gws2019-10-14.pdf Meenakshi Sundram, Tamil Chelvan and Zakaria, Mohd Hazim and Mohd Nasir, Mohd Hamzah (2019) Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines. Science Heritage Journal (GWS), 3 (2). pp. 10-14. ISSN 2521-0858 E-ISSN 2521-0866 https://jscienceheritage.com/archive/#gws-2019-vol3-issue2 10.26480/gws.02.2019.10.14
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QH301 Biology
spellingShingle	QH301 Biology Meenakshi Sundram, Tamil Chelvan Zakaria, Mohd Hazim Mohd Nasir, Mohd Hamzah Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines
description	Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic activity of C. mangga and B. rotunda ethanolic extracts. Initially, in this study, ethanolic extracts from rhizomes of C. mangga and B. rotunda were obtained through Soxhlet extraction method. 12.6% and 3.5% of crude extract were obtained from C. mangga and B. rotunda respectively. For MTT assay, the IC50 values are 207µg/ml and 31.96 µg/ml for C. mangga and B. rotunda respectively. Meanwhile for the antioxidant activity using DPPH assay, C. mangga showed higher antioxidant activity with IC50 values of 1073µg/ml compared to B. rotunda with IC50 values of 578µg/ml. It can be concluded both extracts showed low inhibitory effect on MCF-7 cancer cells growth and DPPH free radical activity.
format	Article
author	Meenakshi Sundram, Tamil Chelvan Zakaria, Mohd Hazim Mohd Nasir, Mohd Hamzah
author_facet	Meenakshi Sundram, Tamil Chelvan Zakaria, Mohd Hazim Mohd Nasir, Mohd Hamzah
author_sort	Meenakshi Sundram, Tamil Chelvan
title	Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines
title_short	Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines
title_full	Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines
title_fullStr	Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines
title_full_unstemmed	Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines
title_sort	antioxidant and cytotoxic effects of curcuma mangga and bosenbergia rotunda ethanolic extracts on mcf-7 cancer cell lines
publisher	Zibeline International Publishing Sdn. Bhd.
publishDate	2019
url	http://irep.iium.edu.my/76737/ http://irep.iium.edu.my/76737/ http://irep.iium.edu.my/76737/ http://irep.iium.edu.my/76737/1/2gws2019-10-14.pdf
first_indexed	2023-09-18T21:48:22Z
last_indexed	2023-09-18T21:48:22Z
_version_	1777413602941075456

Antioxidant and cytotoxic effects of Curcuma mangga and Bosenbergia rotunda ethanolic extracts on Mcf-7 cancer cell lines

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