Matrix metalloproteinases in cancer biology: a review
Matrix metalloproteinases (MMPs) are a group of proteinases that are involved with the enzymatic breakdown of the extracellular matrix and basement membrane components. These enzymes are important in regulating vital physiological functions such as embryonic development, wound healing and tissue rem...
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Kulliyyah of Medicine, International Islamic University Malaysia
2019
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| Online Access: | http://irep.iium.edu.my/76293/ http://irep.iium.edu.my/76293/ http://irep.iium.edu.my/76293/1/76293_Matrix%20metalloproteinases%20in%20cancer%20biology.pdf http://irep.iium.edu.my/76293/2/76293_Matrix%20metalloproteinases%20in%20cancer%20biology_SCOPUS.pdf http://irep.iium.edu.my/76293/13/76293_Matrix%20Metalloproteinases%20In%20Cancer_WOS.pdf |
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iium-762932019-12-26T00:54:31Z http://irep.iium.edu.my/76293/ Matrix metalloproteinases in cancer biology: a review Nabeel, Ibrahim Wisam Abdull Rasad, Mohammad Syaiful Bahari Doolaanea, Abd Almonem R Medicine (General) RS Pharmacy and materia medica Matrix metalloproteinases (MMPs) are a group of proteinases that are involved with the enzymatic breakdown of the extracellular matrix and basement membrane components. These enzymes are important in regulating vital physiological functions such as embryonic development, wound healing and tissue remodelling. However, several disorders may result from the exaggerated function of these enzymes such as ulcers, rheumatoid arthritis and invasive tumours. In tumours, the effect of these enzymes is not limited to invasion as it was traditionally believed but it also extends to the other oncogenic hallmark processes such as proliferation, angiogenesis, epithelial-mesenchymal transition and evasion from apoptosis. Therefore, it is essential to thoroughly understand the molecular mechanisms involved in these enzymes in cancerous tissue based on recent literature. Several reviews have highlighted the function of these enzymes in malignancies however the aim of this was to provide more recent overview to their role in malignant transformation and progression and in a briefer approach summarizing the complex molecular pathways. Online databases such as PubMed, Google scholar, Web of Science and MEDLINE were used to identify relevant articles. This approach would assist researchers by providing a list of the potential molecular targets in the sequence of changes related to these enzymes. Kulliyyah of Medicine, International Islamic University Malaysia 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/76293/1/76293_Matrix%20metalloproteinases%20in%20cancer%20biology.pdf application/pdf en http://irep.iium.edu.my/76293/2/76293_Matrix%20metalloproteinases%20in%20cancer%20biology_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/76293/13/76293_Matrix%20Metalloproteinases%20In%20Cancer_WOS.pdf Nabeel, Ibrahim Wisam and Abdull Rasad, Mohammad Syaiful Bahari and Doolaanea, Abd Almonem (2019) Matrix metalloproteinases in cancer biology: a review. International Medical Journal Malaysia (IMJM), 18 (2). pp. 147-152. ISSN 1823-4631 (Unpublished) http://iiumedic.net/imjm/v1/download/volume_18_no_2/Pages-from-IMJMVol18No2-24.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English English |
| topic |
R Medicine (General) RS Pharmacy and materia medica |
| spellingShingle |
R Medicine (General) RS Pharmacy and materia medica Nabeel, Ibrahim Wisam Abdull Rasad, Mohammad Syaiful Bahari Doolaanea, Abd Almonem Matrix metalloproteinases in cancer biology: a review |
| description |
Matrix metalloproteinases (MMPs) are a group of proteinases that are involved with the enzymatic breakdown of the extracellular matrix and basement membrane components. These enzymes are important in regulating vital physiological functions such as embryonic development, wound healing and tissue remodelling. However, several disorders may result from the exaggerated function of these enzymes such as ulcers, rheumatoid arthritis and invasive tumours. In tumours, the effect of these enzymes is not limited to invasion as it was traditionally believed but it also extends to the other oncogenic hallmark processes such as proliferation, angiogenesis, epithelial-mesenchymal transition and evasion from apoptosis. Therefore, it is essential to thoroughly understand the molecular mechanisms involved in these enzymes in cancerous tissue based on recent literature. Several reviews have highlighted the function of these enzymes in malignancies however the aim of this was to provide more recent overview to their role in malignant transformation and progression and in a briefer approach summarizing the complex molecular pathways. Online databases such as PubMed, Google scholar, Web of Science and MEDLINE were used to identify relevant articles. This approach would assist researchers by providing a list of the potential molecular targets in the sequence of changes related to these enzymes. |
| format |
Article |
| author |
Nabeel, Ibrahim Wisam Abdull Rasad, Mohammad Syaiful Bahari Doolaanea, Abd Almonem |
| author_facet |
Nabeel, Ibrahim Wisam Abdull Rasad, Mohammad Syaiful Bahari Doolaanea, Abd Almonem |
| author_sort |
Nabeel, Ibrahim Wisam |
| title |
Matrix metalloproteinases in cancer biology: a review |
| title_short |
Matrix metalloproteinases in cancer biology: a review |
| title_full |
Matrix metalloproteinases in cancer biology: a review |
| title_fullStr |
Matrix metalloproteinases in cancer biology: a review |
| title_full_unstemmed |
Matrix metalloproteinases in cancer biology: a review |
| title_sort |
matrix metalloproteinases in cancer biology: a review |
| publisher |
Kulliyyah of Medicine, International Islamic University Malaysia |
| publishDate |
2019 |
| url |
http://irep.iium.edu.my/76293/ http://irep.iium.edu.my/76293/ http://irep.iium.edu.my/76293/1/76293_Matrix%20metalloproteinases%20in%20cancer%20biology.pdf http://irep.iium.edu.my/76293/2/76293_Matrix%20metalloproteinases%20in%20cancer%20biology_SCOPUS.pdf http://irep.iium.edu.my/76293/13/76293_Matrix%20Metalloproteinases%20In%20Cancer_WOS.pdf |
| first_indexed |
2023-09-18T21:47:50Z |
| last_indexed |
2023-09-18T21:47:50Z |
| _version_ |
1777413569377206272 |