Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
Preclinical studies have reported that Murraya koenigii leaves (MKL) could enhance memory. MKL is also known for its antioxidant activity. The current study was to assess the possible neuroprotective potential of MKL methanolic extract in a two vessel occlusion (2VO) rat model of partial global c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Kulliyyah of Medicine, International Islamic University Malaysia
2019
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| Online Access: | http://irep.iium.edu.my/76245/ http://irep.iium.edu.my/76245/ http://irep.iium.edu.my/76245/1/76245_Mnemonic%20and%20histopathological%20assessment.pdf http://irep.iium.edu.my/76245/2/76245_Mnemonic%20and%20histopathological%20assessment_SCOPUS.pdf http://irep.iium.edu.my/76245/3/76245_Mnemonic%20and%20histopathological%20assessment_WOS.pdf |
| Summary: | Preclinical studies have reported that Murraya koenigii leaves (MKL) could enhance
memory. MKL is also known for its antioxidant activity. The current study was to assess the possible
neuroprotective potential of MKL methanolic extract in a two vessel occlusion (2VO) rat model of partial
global cerebral ischaemia. Methods: Rats were divided into memory and learning groups. Each group was
subdivided into sham control, untreated 2VO and MKL-treated 2VO subgroups. The Morris water maze test
was implemented to assess the rats’ cognitive function postoperatively. Brain samples were
histopathologically examined for viable neurons within the CA1 hippocampal region. Results: Water maze
test findings showed that MKL positively improved memory and learning impairments. However, this
improvement in memory test for the treated group was still significantly inferior to that of the healthy
control group. Additionally, MKL treated group exhibited insignificant difference in the number of viable
hippocampal CA1 pyramidal neurons from that of the untreated 2VO group, whereas both MKL treated and
untreated 2VO groups showed significantly less viable neurons when compared with the control group.
Conclusion: MKL extract modestly improved memory without providing substantial neuroprotective
action to the hippocampal neurons in rats with chronic partial global cerebral ischaemia. |
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