Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups

The relationship between resting effective connectivity (EC) among default mode network (DMN) regions and auditory working memory (AWM) performance is still poorly understood. In this work, resting-state functional magnetic resonance imaging (rsfMRI) was used to determine the optimum connectivity mo...

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Main Authors:	Othman, Elza Azri, Yusoff, Ahmad Nazli, Mohamad, Mazlyfarina, Abdul Manan, Hanani, Abd Hamid, Aini Ismafairus, Dzulkifli, Mariam Adawiah, Osman, Syazarina Sharis, Dewiputri, Wan Ilma
Format:	Conference or Workshop Item
Language:	English English
Published:	Institute of Physics Publishing 2019
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/76132/ http://irep.iium.edu.my/76132/ http://irep.iium.edu.my/76132/ http://irep.iium.edu.my/76132/1/76132_Resting-state%20fMRI.pdf http://irep.iium.edu.my/76132/2/76132_Resting-state%20fMRI_SCOPUS.pdf

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spelling	iium-761322019-12-05T04:16:27Z http://irep.iium.edu.my/76132/ Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups Othman, Elza Azri Yusoff, Ahmad Nazli Mohamad, Mazlyfarina Abdul Manan, Hanani Abd Hamid, Aini Ismafairus Dzulkifli, Mariam Adawiah Osman, Syazarina Sharis Dewiputri, Wan Ilma QP Physiology The relationship between resting effective connectivity (EC) among default mode network (DMN) regions and auditory working memory (AWM) performance is still poorly understood. In this work, resting-state functional magnetic resonance imaging (rsfMRI) was used to determine the optimum connectivity model between posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) in 40 healthy male volunteers. in low and normal working memory groups of subjects. Correlation between EC with AWM performance and AWM-capacity was also studied. The participants were divided into two groups which are normal and low AWM-capacity groups based on Malay Version Auditory Verbal Learning Test. The AWM performance was assessed using a word-based backward recall task. Both assessments were conducted outside the MRI scanner. The participants were scanned using a 3-T MRI system and the data were analyzed using statistical parametric mapping (SPM12) and spectral Dynamic Causal Modelling (spDCM). Results revealed that PCC and mPFC were significantly interconnected in both groups. Group analyses showed that the connection between PCC and mPFC exhibits an anti-correlated network. The results also indicated that the AWM performance and AWM-capacity were not associated with EC. These findings suggest that EC at rest between the two regions may not significantly influence cognitive abilities important for this AWM task. Institute of Physics Publishing 2019 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/76132/1/76132_Resting-state%20fMRI.pdf application/pdf en http://irep.iium.edu.my/76132/2/76132_Resting-state%20fMRI_SCOPUS.pdf Othman, Elza Azri and Yusoff, Ahmad Nazli and Mohamad, Mazlyfarina and Abdul Manan, Hanani and Abd Hamid, Aini Ismafairus and Dzulkifli, Mariam Adawiah and Osman, Syazarina Sharis and Dewiputri, Wan Ilma (2019) Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups. In: 18th Asia-Oceania Congress of Medical Physics, AOCMP 2018 and 16th South-East Asia Congress of Medical Physics, SEACOMP 2018, 11th -4th November 2018, Kuala Lumpur. https://iopscience.iop.org/article/10.1088/1742-6596/1248/1/012005/pdf 10.1088/1742-6596/1248/1/012005
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Othman, Elza Azri Yusoff, Ahmad Nazli Mohamad, Mazlyfarina Abdul Manan, Hanani Abd Hamid, Aini Ismafairus Dzulkifli, Mariam Adawiah Osman, Syazarina Sharis Dewiputri, Wan Ilma Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups
description	The relationship between resting effective connectivity (EC) among default mode network (DMN) regions and auditory working memory (AWM) performance is still poorly understood. In this work, resting-state functional magnetic resonance imaging (rsfMRI) was used to determine the optimum connectivity model between posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) in 40 healthy male volunteers. in low and normal working memory groups of subjects. Correlation between EC with AWM performance and AWM-capacity was also studied. The participants were divided into two groups which are normal and low AWM-capacity groups based on Malay Version Auditory Verbal Learning Test. The AWM performance was assessed using a word-based backward recall task. Both assessments were conducted outside the MRI scanner. The participants were scanned using a 3-T MRI system and the data were analyzed using statistical parametric mapping (SPM12) and spectral Dynamic Causal Modelling (spDCM). Results revealed that PCC and mPFC were significantly interconnected in both groups. Group analyses showed that the connection between PCC and mPFC exhibits an anti-correlated network. The results also indicated that the AWM performance and AWM-capacity were not associated with EC. These findings suggest that EC at rest between the two regions may not significantly influence cognitive abilities important for this AWM task.
format	Conference or Workshop Item
author	Othman, Elza Azri Yusoff, Ahmad Nazli Mohamad, Mazlyfarina Abdul Manan, Hanani Abd Hamid, Aini Ismafairus Dzulkifli, Mariam Adawiah Osman, Syazarina Sharis Dewiputri, Wan Ilma
author_facet	Othman, Elza Azri Yusoff, Ahmad Nazli Mohamad, Mazlyfarina Abdul Manan, Hanani Abd Hamid, Aini Ismafairus Dzulkifli, Mariam Adawiah Osman, Syazarina Sharis Dewiputri, Wan Ilma
author_sort	Othman, Elza Azri
title	Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups
title_short	Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups
title_full	Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups
title_fullStr	Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups
title_full_unstemmed	Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups
title_sort	resting-state fmri: comparing default mode network connectivity between normal and low auditory working memory groups
publisher	Institute of Physics Publishing
publishDate	2019
url	http://irep.iium.edu.my/76132/ http://irep.iium.edu.my/76132/ http://irep.iium.edu.my/76132/ http://irep.iium.edu.my/76132/1/76132_Resting-state%20fMRI.pdf http://irep.iium.edu.my/76132/2/76132_Resting-state%20fMRI_SCOPUS.pdf
first_indexed	2023-09-18T21:47:37Z
last_indexed	2023-09-18T21:47:37Z
_version_	1777413555864207360

Resting-state fMRI: comparing default mode network connectivity between normal and low auditory working memory groups

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