Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use

This study aimed to develop a carbamazepine (CBZ) sustained release formulation suitable for pediatric use with a lower risk of precipitation. The CBZ was first prepared as sustained release microparticles, and then the microparticles were embedded in alginate beads, and finally, the beads were susp...

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Main Authors:	Mawazi, Saeid Mezail, Abdullah Al-Mahmood, Sinan Mohammed, Chatterjee, Bappaditya, Ab. Hadi, Hazrina, Doolaanea, Abd Almonem
Format:	Article
Language:	English English
Published:	MDPI AG 2019
Subjects:	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/76103/ http://irep.iium.edu.my/76103/ http://irep.iium.edu.my/76103/1/pharmaceutics-11-00488-v2.pdf http://irep.iium.edu.my/76103/7/Scopus%20-%20carbamazepine.pdf

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recordtype	eprints
spelling	iium-761032019-11-13T03:57:37Z http://irep.iium.edu.my/76103/ Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use Mawazi, Saeid Mezail Abdullah Al-Mahmood, Sinan Mohammed Chatterjee, Bappaditya Ab. Hadi, Hazrina Doolaanea, Abd Almonem RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology This study aimed to develop a carbamazepine (CBZ) sustained release formulation suitable for pediatric use with a lower risk of precipitation. The CBZ was first prepared as sustained release microparticles, and then the microparticles were embedded in alginate beads, and finally, the beads were suspended in a gel vehicle. The microparticles were prepared by a solvent evaporation method utilizing ethyl cellulose as a sustained release polymer and were evaluated for particle size, encapsulation efficiency, and release profile. The beads were fabricated by the dropwise addition of sodium alginate in calcium chloride solution and characterized for size, shape, and release properties. The gel was prepared using iota carrageenan as the gelling agent and evaluated for appearance, syneresis, drug content uniformity, rheology, release profile, and stability. The microparticles exhibited a particle size of 135.01 ± 0.61 µm with a monodisperse distribution and an encapsulation efficiency of 83.89 ± 3.98%. The beads were monodispersed with an average size of 1.4 ± 0.05 mm and a sphericity factor of less than 0.05. The gel was prepared using a 1:1 ratio (gel vehicle to beads) and exhibited no syneresis, good homogeneity, and good shearthinning properties. The release profile from the beads and from the gel was not significantly affected, maintaining similarity to the tablet form. The gel properties were maintained for one month real time stability, but the accelerated stability showed reduced viscosity and pH with time. In conclusion, CBZ in a gel sustained release dosage form combines the advantages of the suspension form in terms of dosing flexibility, and the advantages of the tablet form in regards to the sustained release profile. This dosage form should be further investigated in vivo in animal models before being considered in clinical trials. MDPI AG 2019-11 Article PeerReviewed application/pdf en cc_by http://irep.iium.edu.my/76103/1/pharmaceutics-11-00488-v2.pdf application/pdf en http://irep.iium.edu.my/76103/7/Scopus%20-%20carbamazepine.pdf Mawazi, Saeid Mezail and Abdullah Al-Mahmood, Sinan Mohammed and Chatterjee, Bappaditya and Ab. Hadi, Hazrina and Doolaanea, Abd Almonem (2019) Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use. Pharmaceutics, 11 (10). pp. 1-13. ISSN 1999-4923 10.3390/pharmaceutics11100488
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Mawazi, Saeid Mezail Abdullah Al-Mahmood, Sinan Mohammed Chatterjee, Bappaditya Ab. Hadi, Hazrina Doolaanea, Abd Almonem Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
description	This study aimed to develop a carbamazepine (CBZ) sustained release formulation suitable for pediatric use with a lower risk of precipitation. The CBZ was first prepared as sustained release microparticles, and then the microparticles were embedded in alginate beads, and finally, the beads were suspended in a gel vehicle. The microparticles were prepared by a solvent evaporation method utilizing ethyl cellulose as a sustained release polymer and were evaluated for particle size, encapsulation efficiency, and release profile. The beads were fabricated by the dropwise addition of sodium alginate in calcium chloride solution and characterized for size, shape, and release properties. The gel was prepared using iota carrageenan as the gelling agent and evaluated for appearance, syneresis, drug content uniformity, rheology, release profile, and stability. The microparticles exhibited a particle size of 135.01 ± 0.61 µm with a monodisperse distribution and an encapsulation efficiency of 83.89 ± 3.98%. The beads were monodispersed with an average size of 1.4 ± 0.05 mm and a sphericity factor of less than 0.05. The gel was prepared using a 1:1 ratio (gel vehicle to beads) and exhibited no syneresis, good homogeneity, and good shearthinning properties. The release profile from the beads and from the gel was not significantly affected, maintaining similarity to the tablet form. The gel properties were maintained for one month real time stability, but the accelerated stability showed reduced viscosity and pH with time. In conclusion, CBZ in a gel sustained release dosage form combines the advantages of the suspension form in terms of dosing flexibility, and the advantages of the tablet form in regards to the sustained release profile. This dosage form should be further investigated in vivo in animal models before being considered in clinical trials.
format	Article
author	Mawazi, Saeid Mezail Abdullah Al-Mahmood, Sinan Mohammed Chatterjee, Bappaditya Ab. Hadi, Hazrina Doolaanea, Abd Almonem
author_facet	Mawazi, Saeid Mezail Abdullah Al-Mahmood, Sinan Mohammed Chatterjee, Bappaditya Ab. Hadi, Hazrina Doolaanea, Abd Almonem
author_sort	Mawazi, Saeid Mezail
title	Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
title_short	Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
title_full	Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
title_fullStr	Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
title_full_unstemmed	Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
title_sort	carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use
publisher	MDPI AG
publishDate	2019
url	http://irep.iium.edu.my/76103/ http://irep.iium.edu.my/76103/ http://irep.iium.edu.my/76103/1/pharmaceutics-11-00488-v2.pdf http://irep.iium.edu.my/76103/7/Scopus%20-%20carbamazepine.pdf
first_indexed	2023-09-18T21:47:35Z
last_indexed	2023-09-18T21:47:35Z
_version_	1777413553391665152

Carbamazepine gel formulation as a sustained release epilepsy medication for pediatric use

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