The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities

Anacardium occidentale Linn. (A. occidentale L.) leaves possess an excellent source of bioactive compounds, which are associated with numerous health benefits including antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). The management strategies for T2DM include to maintain...

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Main Authors:	Abdullah Thaidi, Nur Imanina, Mat Jusoh, Hanapi, Ghazali, Ahmad Badruddin, Haron, Normah
Format:	Article
Language:	English
Published:	Gagjah Mada University 2019
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://irep.iium.edu.my/76000/ http://irep.iium.edu.my/76000/ http://irep.iium.edu.my/76000/1/nur%20imanina.%20correction%20-jmbfs.pdf

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spelling	iium-760002019-12-05T10:09:57Z http://irep.iium.edu.my/76000/ The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities Abdullah Thaidi, Nur Imanina Mat Jusoh, Hanapi Ghazali, Ahmad Badruddin Haron, Normah Q Science (General) QD Chemistry Anacardium occidentale Linn. (A. occidentale L.) leaves possess an excellent source of bioactive compounds, which are associated with numerous health benefits including antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). The management strategies for T2DM include to maintain the postprandial blood glucose level through the inhibition of α-amylase and to prevent the hydrolysis of glucagon like peptide-1 (GLP-1) through the inhibition of dipeptidyl peptidase IV (DPPIV). In this study, free, soluble ester and insoluble bound phenolic fractions from young and matured leaves of A. occidentale L. were extracted and analyzed using high performance liquid chromatography (HPLC). Subsequently, all fractions were investigated for their inhibitory effect on α-amylase and DPPIV enzymes activities. Both free (72.45 ± 3.6%) and soluble ester (83.40 ± 4.7%) phenolic fractions in the matured leaves extracts had significantly demonstrated greater α-amylase inhibitors than the young leaves. Likewise, soluble ester (4.09 ± 0.34 µg/ml) and insoluble bound (4.87 ± 0.32 µg/ml) phenolic fractions in the matured leaves extracts were significantly more effective in inhibiting DPPIV than the young leaves. As for fractions comparison, insoluble bound derived from the young leaves extract was a more potent α-amylase inhibitor than free and soluble ester phenolic fractions (p<0.0001). In addition, soluble ester and insoluble bound phenolic fractions showed a stronger inhibitor of DPPIV than free phenolic (p<0.001), irrespective of maturity of the leaves. In conclusion, this study showed that A. occidentale L. extracts possessed antidiabetic properties which may potentially be used as an alternative treatment for T2DM management. Gagjah Mada University 2019-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/76000/1/nur%20imanina.%20correction%20-jmbfs.pdf Abdullah Thaidi, Nur Imanina and Mat Jusoh, Hanapi and Ghazali, Ahmad Badruddin and Haron, Normah (2019) The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities. Indonesia Journal of Chemistry. ISSN 1411-9420 E-ISSN 2460-1578 (In Press) https://jurnal.ugm.ac.id/ijc/index
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Abdullah Thaidi, Nur Imanina Mat Jusoh, Hanapi Ghazali, Ahmad Badruddin Haron, Normah The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities
description	Anacardium occidentale Linn. (A. occidentale L.) leaves possess an excellent source of bioactive compounds, which are associated with numerous health benefits including antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). The management strategies for T2DM include to maintain the postprandial blood glucose level through the inhibition of α-amylase and to prevent the hydrolysis of glucagon like peptide-1 (GLP-1) through the inhibition of dipeptidyl peptidase IV (DPPIV). In this study, free, soluble ester and insoluble bound phenolic fractions from young and matured leaves of A. occidentale L. were extracted and analyzed using high performance liquid chromatography (HPLC). Subsequently, all fractions were investigated for their inhibitory effect on α-amylase and DPPIV enzymes activities. Both free (72.45 ± 3.6%) and soluble ester (83.40 ± 4.7%) phenolic fractions in the matured leaves extracts had significantly demonstrated greater α-amylase inhibitors than the young leaves. Likewise, soluble ester (4.09 ± 0.34 µg/ml) and insoluble bound (4.87 ± 0.32 µg/ml) phenolic fractions in the matured leaves extracts were significantly more effective in inhibiting DPPIV than the young leaves. As for fractions comparison, insoluble bound derived from the young leaves extract was a more potent α-amylase inhibitor than free and soluble ester phenolic fractions (p<0.0001). In addition, soluble ester and insoluble bound phenolic fractions showed a stronger inhibitor of DPPIV than free phenolic (p<0.001), irrespective of maturity of the leaves. In conclusion, this study showed that A. occidentale L. extracts possessed antidiabetic properties which may potentially be used as an alternative treatment for T2DM management.
format	Article
author	Abdullah Thaidi, Nur Imanina Mat Jusoh, Hanapi Ghazali, Ahmad Badruddin Haron, Normah
author_facet	Abdullah Thaidi, Nur Imanina Mat Jusoh, Hanapi Ghazali, Ahmad Badruddin Haron, Normah
author_sort	Abdullah Thaidi, Nur Imanina
title	The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities
title_short	The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities
title_full	The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities
title_fullStr	The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities
title_full_unstemmed	The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities
title_sort	effect of bioactive polyphenols from anacardium occidentale linn. leaves on α-amylase and dipeptidyl peptidase iv activities
publisher	Gagjah Mada University
publishDate	2019
url	http://irep.iium.edu.my/76000/ http://irep.iium.edu.my/76000/ http://irep.iium.edu.my/76000/1/nur%20imanina.%20correction%20-jmbfs.pdf
first_indexed	2023-09-18T21:47:28Z
last_indexed	2023-09-18T21:47:28Z
_version_	1777413546239328256

The effect of bioactive polyphenols from anacardium occidentale linn. Leaves on α-amylase and dipeptidyl peptidase iv activities

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