Melioidosis in Pahang

A state-wide review of melioidosis cases from year 2000 to 2005 in Pahang, Malaysia showed a high annual incidence and mortality rate, likely due to inappropriate antibiotics. A series of medical education programme was implemented throughout Pahang and a registry was setup to monitor the impact. A...

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Main Authors:	How, Soon Hin, Wan Ramli, Wan Nurliyana, Ab Rahman, Jamalludin, Bee, Chiu Lim, Kaur, Kiren, Saub, Ros, Thian, Chee Loh, Wan Azman, Siti Sanaa, Fong, Von Ken, Sulomg, Mohd Rahim
Format:	Article
Language:	English
Published:	Universiti Sultan Zainal Abidin (UniSZA) 2018
Subjects:	RC Internal medicine RC111 Infectious and Parasitic Diseases
Online Access:	http://irep.iium.edu.my/75761/ http://irep.iium.edu.my/75761/ http://irep.iium.edu.my/75761/14/75761abstract.pdf

id	iium-75761
recordtype	eprints
spelling	iium-757612019-11-28T06:24:38Z http://irep.iium.edu.my/75761/ Melioidosis in Pahang How, Soon Hin Wan Ramli, Wan Nurliyana Ab Rahman, Jamalludin Bee, Chiu Lim Kaur, Kiren Saub, Ros Thian, Chee Loh Wan Azman, Siti Sanaa Fong, Von Ken Sulomg, Mohd Rahim RC Internal medicine RC111 Infectious and Parasitic Diseases A state-wide review of melioidosis cases from year 2000 to 2005 in Pahang, Malaysia showed a high annual incidence and mortality rate, likely due to inappropriate antibiotics. A series of medical education programme was implemented throughout Pahang and a registry was setup to monitor the impact. A retrospective review was performed to validate data from registry and culture-confirmed melioidosis cases occurring in between year 2011 and 2015 from all microbiology laboratories across Pahang. Incomplete information from registry was verified from patient’s case note. Characteristics, predisposing factors, clinical presentation, sensitivity and outcome of melioidosis were obtained. During the five-year study period, a total of 294 patients had positive culture for Burkholderia pseudomallei. Majority were Malays and male, with median age of 52 years old. Diabetes was the most common predisposing factor, which was present in 72.6% of patients, followed by chronic renal failure. Pneumonia was the most frequent clinical presentation, which was seen in 43.6% of patients. 82% of patients had bacteremia. Among 210 patients with known outcome, 46.2% of patients died. For those patients discharged well, appropriate antibiotics were given to almost all. The relapse rate was only 1.7% as compared to 19% from 2000 to 2003. There was no increased resistance in the commonly used antibiotics for melioidosis. Despite improvement of patient management after an extensive education programme, mortality remained high. Universiti Sultan Zainal Abidin (UniSZA) 2018-08-16 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75761/14/75761abstract.pdf How, Soon Hin and Wan Ramli, Wan Nurliyana and Ab Rahman, Jamalludin and Bee, Chiu Lim and Kaur, Kiren and Saub, Ros and Thian, Chee Loh and Wan Azman, Siti Sanaa and Fong, Von Ken and Sulomg, Mohd Rahim (2018) Melioidosis in Pahang. Asian Journal of Medicine and Biomedicine, 1 (Supplementary 1, 2018 (UICID 2018)). p. 8. E-ISSN 2600-8173 https://journal.unisza.edu.my/ajmb/index.php/ajmb/article/view/57/18
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine RC111 Infectious and Parasitic Diseases
spellingShingle	RC Internal medicine RC111 Infectious and Parasitic Diseases How, Soon Hin Wan Ramli, Wan Nurliyana Ab Rahman, Jamalludin Bee, Chiu Lim Kaur, Kiren Saub, Ros Thian, Chee Loh Wan Azman, Siti Sanaa Fong, Von Ken Sulomg, Mohd Rahim Melioidosis in Pahang
description	A state-wide review of melioidosis cases from year 2000 to 2005 in Pahang, Malaysia showed a high annual incidence and mortality rate, likely due to inappropriate antibiotics. A series of medical education programme was implemented throughout Pahang and a registry was setup to monitor the impact. A retrospective review was performed to validate data from registry and culture-confirmed melioidosis cases occurring in between year 2011 and 2015 from all microbiology laboratories across Pahang. Incomplete information from registry was verified from patient’s case note. Characteristics, predisposing factors, clinical presentation, sensitivity and outcome of melioidosis were obtained. During the five-year study period, a total of 294 patients had positive culture for Burkholderia pseudomallei. Majority were Malays and male, with median age of 52 years old. Diabetes was the most common predisposing factor, which was present in 72.6% of patients, followed by chronic renal failure. Pneumonia was the most frequent clinical presentation, which was seen in 43.6% of patients. 82% of patients had bacteremia. Among 210 patients with known outcome, 46.2% of patients died. For those patients discharged well, appropriate antibiotics were given to almost all. The relapse rate was only 1.7% as compared to 19% from 2000 to 2003. There was no increased resistance in the commonly used antibiotics for melioidosis. Despite improvement of patient management after an extensive education programme, mortality remained high.
format	Article
author	How, Soon Hin Wan Ramli, Wan Nurliyana Ab Rahman, Jamalludin Bee, Chiu Lim Kaur, Kiren Saub, Ros Thian, Chee Loh Wan Azman, Siti Sanaa Fong, Von Ken Sulomg, Mohd Rahim
author_facet	How, Soon Hin Wan Ramli, Wan Nurliyana Ab Rahman, Jamalludin Bee, Chiu Lim Kaur, Kiren Saub, Ros Thian, Chee Loh Wan Azman, Siti Sanaa Fong, Von Ken Sulomg, Mohd Rahim
author_sort	How, Soon Hin
title	Melioidosis in Pahang
title_short	Melioidosis in Pahang
title_full	Melioidosis in Pahang
title_fullStr	Melioidosis in Pahang
title_full_unstemmed	Melioidosis in Pahang
title_sort	melioidosis in pahang
publisher	Universiti Sultan Zainal Abidin (UniSZA)
publishDate	2018
url	http://irep.iium.edu.my/75761/ http://irep.iium.edu.my/75761/ http://irep.iium.edu.my/75761/14/75761abstract.pdf
first_indexed	2023-09-18T21:47:10Z
last_indexed	2023-09-18T21:47:10Z
_version_	1777413527448846336

Melioidosis in Pahang

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