Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs

Liver is the central organ of the body where all the absorbed compounds including the dietary components, drugs are dispatched for further metabolism. This action of liver causes altered production of enzymes. In medical practice particularly when dealing with lowering of blood lipids in type 2 diab...

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Main Authors:	Mahmood, Tahir, Ali Khan Khattak, Muhammad Muzaffar, Mohd-Shukri, Nor Azwani
Format:	Conference or Workshop Item
Language:	English
Published:	2019
Subjects:	TX341 Nutrition. Foods and food supply
Online Access:	http://irep.iium.edu.my/75508/ http://irep.iium.edu.my/75508/1/75508_Improvement%20of%20HbA1c%20in%20Type%202%20Diabetes_complete.pdf

id	iium-75508
recordtype	eprints
spelling	iium-755082019-11-21T11:13:41Z http://irep.iium.edu.my/75508/ Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs Mahmood, Tahir Ali Khan Khattak, Muhammad Muzaffar Mohd-Shukri, Nor Azwani TX341 Nutrition. Foods and food supply Liver is the central organ of the body where all the absorbed compounds including the dietary components, drugs are dispatched for further metabolism. This action of liver causes altered production of enzymes. In medical practice particularly when dealing with lowering of blood lipids in type 2 diabetes (T2DM) patients it is essential to assess the liver function test. The aim of this study was to assess the effect of mixed herbs on the liver function tests and blood HbA1c in T2DM patients. In this study we examined the effect of four herbs in T2DM patients. Freshly purchased herbs were cleaned, freeze-dried, ground, mixed (25% of each herb), encapsulated and 4g were fed to the T2DM patients for 90 days. Blood samples were collected at day 0, 31, 61, 91 & 121. The effect was assessed on the HbA1c and creatinine, blood urea concentration. The liver enzymes i.e. Alanine Transaminase (ALT) or serum glutamic-pyruvic transaminase (SGPT), Aspartate aminotransferase (AST) or serum glutamic-oxaloacetic transaminase (SGOT), Alkaline phosphatase (ALP) concentration among the patients. The data was statistical analysed and the differences in the means was regarded as significant at 95% confidence interval. The HbA1c was highest on day 0 & 31 and significantly (p<0.001 & p<0.01) lower on the day 61, 91 and 121. Creatinine concentration was highest on day 61 and followed by day 91, 121. The blood urea concentration in the blood was not affected due to the larger variation among the subjects. The ALT and AST concentration was higher (p<0.001) at day 61 and started to decline afterwards. The concentration of ALP was higher on the day 0 & 31 and started declining from day 61 onwards. Apparently, the consumption of mixed herbs was associated with an improvement of HbA1c in the T2DM patients. 2019-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/75508/1/75508_Improvement%20of%20HbA1c%20in%20Type%202%20Diabetes_complete.pdf Mahmood, Tahir and Ali Khan Khattak, Muhammad Muzaffar and Mohd-Shukri, Nor Azwani (2019) Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs. In: MASO 2019 : Scientific Conference on Obesity, 15-16-10-2019, Istana Hotel Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TX341 Nutrition. Foods and food supply
spellingShingle	TX341 Nutrition. Foods and food supply Mahmood, Tahir Ali Khan Khattak, Muhammad Muzaffar Mohd-Shukri, Nor Azwani Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
description	Liver is the central organ of the body where all the absorbed compounds including the dietary components, drugs are dispatched for further metabolism. This action of liver causes altered production of enzymes. In medical practice particularly when dealing with lowering of blood lipids in type 2 diabetes (T2DM) patients it is essential to assess the liver function test. The aim of this study was to assess the effect of mixed herbs on the liver function tests and blood HbA1c in T2DM patients. In this study we examined the effect of four herbs in T2DM patients. Freshly purchased herbs were cleaned, freeze-dried, ground, mixed (25% of each herb), encapsulated and 4g were fed to the T2DM patients for 90 days. Blood samples were collected at day 0, 31, 61, 91 & 121. The effect was assessed on the HbA1c and creatinine, blood urea concentration. The liver enzymes i.e. Alanine Transaminase (ALT) or serum glutamic-pyruvic transaminase (SGPT), Aspartate aminotransferase (AST) or serum glutamic-oxaloacetic transaminase (SGOT), Alkaline phosphatase (ALP) concentration among the patients. The data was statistical analysed and the differences in the means was regarded as significant at 95% confidence interval. The HbA1c was highest on day 0 & 31 and significantly (p<0.001 & p<0.01) lower on the day 61, 91 and 121. Creatinine concentration was highest on day 61 and followed by day 91, 121. The blood urea concentration in the blood was not affected due to the larger variation among the subjects. The ALT and AST concentration was higher (p<0.001) at day 61 and started to decline afterwards. The concentration of ALP was higher on the day 0 & 31 and started declining from day 61 onwards. Apparently, the consumption of mixed herbs was associated with an improvement of HbA1c in the T2DM patients.
format	Conference or Workshop Item
author	Mahmood, Tahir Ali Khan Khattak, Muhammad Muzaffar Mohd-Shukri, Nor Azwani
author_facet	Mahmood, Tahir Ali Khan Khattak, Muhammad Muzaffar Mohd-Shukri, Nor Azwani
author_sort	Mahmood, Tahir
title	Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
title_short	Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
title_full	Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
title_fullStr	Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
title_full_unstemmed	Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
title_sort	improvement of hba1c in type 2 diabetes mellitus patients by supplementation of mixed herbs
publishDate	2019
url	http://irep.iium.edu.my/75508/ http://irep.iium.edu.my/75508/1/75508_Improvement%20of%20HbA1c%20in%20Type%202%20Diabetes_complete.pdf
first_indexed	2023-09-18T21:46:50Z
last_indexed	2023-09-18T21:46:50Z
_version_	1777413506394488832

Improvement of HbA1c in type 2 diabetes mellitus patients by supplementation of mixed herbs

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