Male reproductive toxicity studies of Orthosiphon stamineus aqueous extract in Sprague Dawley rats
A dose-response study was designed to assess toxicity effects of standardized O. stamineus aqueous extract (OSAE) in adult male Sprague Dawley rats via oral gavage for 60 days. Animals were observed for clinical signs. Body weight gain, food and water consumption and reproductive performance were...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AkiNik Publications
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/75285/ http://irep.iium.edu.my/75285/ http://irep.iium.edu.my/75285/7/75285%20Male%20reproductive%20toxicity%20studies%20of%20Orthosiphon.pdf |
| Summary: | A dose-response study was designed to assess toxicity effects of standardized O. stamineus aqueous
extract (OSAE) in adult male Sprague Dawley rats via oral gavage for 60 days. Animals were observed
for clinical signs. Body weight gain, food and water consumption and reproductive performance were
measured. Animals were sacrificed and blood samples were withdrawn for hematological analysis. Vital
and reproductive organs weight, sperm concentration and morphology were collected and evaluated. All
animals survived and did not show signs of toxicity. No significant changes on food and water uptake,
body and organs weight in all groups. The number of implantation, sperm concentrations, morphology,
resorptions and lives fetuses was not statistically significant. Levels of red blood cells, haematocrit,
haemoglobin and platelet were significantly higher in rats received 2000mg/kg body weight of extract.
The OSAE did not cause toxicity effects, rather, it stimulate erythropoiesis in rats and need further
investigation. |
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