Palm olein emulsions potential vehicles for drug delivery

Palm olein emulsions were produced using the combinations of Span® and Tween® surfactants by mechanical homogenisation. Effects of the types of surfactants, concentrations, effective HLB and the types of viscosity modifiers and concentrations on the characteristics of the emulsions were investigated...

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Main Authors:	Mohd Nawi, Mohamed Sufian, Ahmad, Kausar
Format:	Book
Language:	English
Published:	IIUM Press, International Islamic University Malaysia 2017
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/75257/ http://irep.iium.edu.my/75257/1/75257_Palm%20olein%20emulsions%20potential%20vehicles%20for%20drug%20delivery.pdf

id	iium-75257
recordtype	eprints
spelling	iium-752572019-10-09T07:52:25Z http://irep.iium.edu.my/75257/ Palm olein emulsions potential vehicles for drug delivery Mohd Nawi, Mohamed Sufian Ahmad, Kausar RM Therapeutics. Pharmacology Palm olein emulsions were produced using the combinations of Span® and Tween® surfactants by mechanical homogenisation. Effects of the types of surfactants, concentrations, effective HLB and the types of viscosity modifiers and concentrations on the characteristics of the emulsions were investigated. With palm olein content of 20% (w/w), stable oil droplets were produced at HLB values ranging from 8.5 to 11.0. Optimal concentrations of surfactants ranged from 25 to 30% (w/w to oil) depending on the types of the Span®/Tween® mixtures. Among the viscosity modifiers used, Carbopol®940 was the most effective. Suitable concentrations of Carbopol®940 for the emulsions prepared with Span®20/Tween®20 ranged from 0.1 to 0.3% (w/w). Beyond this concentration, destabilisation of emulsion due to at least depletion of water molecules could have occurred as a result of competitive hydration between Carbopol®940 and the surfactants. The emulsions produced exhibited viscoelastic and pseudoplastic behaviour, with yield value ranging from 0.1 to 35.2 Pa. Depending on the concentration of Carbopol®940 and within the linear viscoelastic region, the emulsions were elastic in nature as shown by domination of storage modulus (G’) over the loss modulus (G”) and with tan δ < 1 in the frequency range of 0.01 to 10 Hz. These favourable rheological properties were induced by the formation of three-dimensional network of Carbopol®940 molecules in the continuous aqueous phase, which also entrapped the oil droplets and thus increased the stability of the emulsion IIUM Press, International Islamic University Malaysia 2017 Book PeerReviewed application/pdf en http://irep.iium.edu.my/75257/1/75257_Palm%20olein%20emulsions%20potential%20vehicles%20for%20drug%20delivery.pdf Mohd Nawi, Mohamed Sufian and Ahmad, Kausar (2017) Palm olein emulsions potential vehicles for drug delivery. IIUM Press, International Islamic University Malaysia, Kuala Lumpur , Malaysia. ISBN 978-967-418-700-2
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Mohd Nawi, Mohamed Sufian Ahmad, Kausar Palm olein emulsions potential vehicles for drug delivery
description	Palm olein emulsions were produced using the combinations of Span® and Tween® surfactants by mechanical homogenisation. Effects of the types of surfactants, concentrations, effective HLB and the types of viscosity modifiers and concentrations on the characteristics of the emulsions were investigated. With palm olein content of 20% (w/w), stable oil droplets were produced at HLB values ranging from 8.5 to 11.0. Optimal concentrations of surfactants ranged from 25 to 30% (w/w to oil) depending on the types of the Span®/Tween® mixtures. Among the viscosity modifiers used, Carbopol®940 was the most effective. Suitable concentrations of Carbopol®940 for the emulsions prepared with Span®20/Tween®20 ranged from 0.1 to 0.3% (w/w). Beyond this concentration, destabilisation of emulsion due to at least depletion of water molecules could have occurred as a result of competitive hydration between Carbopol®940 and the surfactants. The emulsions produced exhibited viscoelastic and pseudoplastic behaviour, with yield value ranging from 0.1 to 35.2 Pa. Depending on the concentration of Carbopol®940 and within the linear viscoelastic region, the emulsions were elastic in nature as shown by domination of storage modulus (G’) over the loss modulus (G”) and with tan δ < 1 in the frequency range of 0.01 to 10 Hz. These favourable rheological properties were induced by the formation of three-dimensional network of Carbopol®940 molecules in the continuous aqueous phase, which also entrapped the oil droplets and thus increased the stability of the emulsion
format	Book
author	Mohd Nawi, Mohamed Sufian Ahmad, Kausar
author_facet	Mohd Nawi, Mohamed Sufian Ahmad, Kausar
author_sort	Mohd Nawi, Mohamed Sufian
title	Palm olein emulsions potential vehicles for drug delivery
title_short	Palm olein emulsions potential vehicles for drug delivery
title_full	Palm olein emulsions potential vehicles for drug delivery
title_fullStr	Palm olein emulsions potential vehicles for drug delivery
title_full_unstemmed	Palm olein emulsions potential vehicles for drug delivery
title_sort	palm olein emulsions potential vehicles for drug delivery
publisher	IIUM Press, International Islamic University Malaysia
publishDate	2017
url	http://irep.iium.edu.my/75257/ http://irep.iium.edu.my/75257/1/75257_Palm%20olein%20emulsions%20potential%20vehicles%20for%20drug%20delivery.pdf
first_indexed	2023-09-18T21:46:29Z
last_indexed	2023-09-18T21:46:29Z
_version_	1777413484122734592

Palm olein emulsions potential vehicles for drug delivery

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