Biodegradable microparticles and nanoparticles by electrospraying techniques

Purpose: Biodegradable microparticles and nanoparticles are receiving increased attention for their ability to serve as a vi- able carrier for site-specific delivery of genes, drugs and other biomolecules. Electrospraying represents a challenging tech- nology which allows for the preparation of biod...

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Main Authors:	Guarino, Vincenzo, Wan Abdul Khodir, Wan Kartini, Ambrosio, Luigi
Format:	Article
Language:	English
Published:	SAGE Publishing 2012
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/75244/ http://irep.iium.edu.my/75244/ http://irep.iium.edu.my/75244/ http://irep.iium.edu.my/75244/1/guarino2012_JABFM.pdf

id	iium-75244
recordtype	eprints
spelling	iium-752442019-11-14T03:39:50Z http://irep.iium.edu.my/75244/ Biodegradable microparticles and nanoparticles by electrospraying techniques Guarino, Vincenzo Wan Abdul Khodir, Wan Kartini Ambrosio, Luigi QD Chemistry Purpose: Biodegradable microparticles and nanoparticles are receiving increased attention for their ability to serve as a vi- able carrier for site-specific delivery of genes, drugs and other biomolecules. Electrospraying represents a challenging tech- nology which allows for the preparation of biodegradable particles with high bioavailability, good encapsulation, controlled release and fewer toxic properties. Methods: chitosan and polycaprolactone (PcL) particles were processed via electrospraying with control of basic process parameters: voltage and flow rate. Results: PcL microparticles with spherical shape or flattened particles were obtained as a function of the concentration of the processed solutions, which affects evaporation and chain entanglement formation. chitosan nanoparticles with submi- crometric sizes were obtained by carefully adjusting voltage and flow rate, which enables the control of particle size and distribution. Conclusion: We evaluated the benefits of the electrospraying technique to control the morphology of biodegradable mic- roparticles and nanoparticles for drug-delivery applications. the implementation of simple technological solutions which combine the use of standard electrospraying and electrospinning by simultaneous or sequential steps, opens the way toward the development of new, interesting devices for drug-delivery applications such as tumor targeting and oral delivery. SAGE Publishing 2012-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75244/1/guarino2012_JABFM.pdf Guarino, Vincenzo and Wan Abdul Khodir, Wan Kartini and Ambrosio, Luigi (2012) Biodegradable microparticles and nanoparticles by electrospraying techniques. Journal of Applied Biomaterials & Functional Materials, 10 (3 (September-December)). pp. 191-196. ISSN 2280-8000 E-ISSN 2280-8000 https://journals.sagepub.com/doi/pdf/10.5301/JABFM.2012.10369 10.5301/JABFM.2012.10369
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Guarino, Vincenzo Wan Abdul Khodir, Wan Kartini Ambrosio, Luigi Biodegradable microparticles and nanoparticles by electrospraying techniques
description	Purpose: Biodegradable microparticles and nanoparticles are receiving increased attention for their ability to serve as a vi- able carrier for site-specific delivery of genes, drugs and other biomolecules. Electrospraying represents a challenging tech- nology which allows for the preparation of biodegradable particles with high bioavailability, good encapsulation, controlled release and fewer toxic properties. Methods: chitosan and polycaprolactone (PcL) particles were processed via electrospraying with control of basic process parameters: voltage and flow rate. Results: PcL microparticles with spherical shape or flattened particles were obtained as a function of the concentration of the processed solutions, which affects evaporation and chain entanglement formation. chitosan nanoparticles with submi- crometric sizes were obtained by carefully adjusting voltage and flow rate, which enables the control of particle size and distribution. Conclusion: We evaluated the benefits of the electrospraying technique to control the morphology of biodegradable mic- roparticles and nanoparticles for drug-delivery applications. the implementation of simple technological solutions which combine the use of standard electrospraying and electrospinning by simultaneous or sequential steps, opens the way toward the development of new, interesting devices for drug-delivery applications such as tumor targeting and oral delivery.
format	Article
author	Guarino, Vincenzo Wan Abdul Khodir, Wan Kartini Ambrosio, Luigi
author_facet	Guarino, Vincenzo Wan Abdul Khodir, Wan Kartini Ambrosio, Luigi
author_sort	Guarino, Vincenzo
title	Biodegradable microparticles and nanoparticles by electrospraying techniques
title_short	Biodegradable microparticles and nanoparticles by electrospraying techniques
title_full	Biodegradable microparticles and nanoparticles by electrospraying techniques
title_fullStr	Biodegradable microparticles and nanoparticles by electrospraying techniques
title_full_unstemmed	Biodegradable microparticles and nanoparticles by electrospraying techniques
title_sort	biodegradable microparticles and nanoparticles by electrospraying techniques
publisher	SAGE Publishing
publishDate	2012
url	http://irep.iium.edu.my/75244/ http://irep.iium.edu.my/75244/ http://irep.iium.edu.my/75244/ http://irep.iium.edu.my/75244/1/guarino2012_JABFM.pdf
first_indexed	2023-09-18T21:46:28Z
last_indexed	2023-09-18T21:46:28Z
_version_	1777413482767974400

Biodegradable microparticles and nanoparticles by electrospraying techniques

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