Microbiology of diabetic foot infections in three district hospital in Malaysia and comparison with South East Asian Countries
Introduction: Diabetic foot infection, a complication that is associated with lower-limb amputation, incurs a huge economic burden to the hospital and health care system of Malaysia. The bacteriological profile of pathogens in diabetic foot infections in Malaysia has been sparsely studied. We i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Malaysian Medical Association
2019
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/75101/ http://irep.iium.edu.my/75101/ http://irep.iium.edu.my/75101/1/7-Microbiology00214R1-1.pdf http://irep.iium.edu.my/75101/7/75101_Microbiology%20of%20diabetic%20foot%20infections%20in%20three%20district%20hospital%20in%20malaysia%20and%20comparison%20with%20south%20east%20asian%20countries_Scopus.pdf |
| id |
iium-75101 |
|---|---|
| recordtype |
eprints |
| spelling |
iium-751012019-11-20T06:27:37Z http://irep.iium.edu.my/75101/ Microbiology of diabetic foot infections in three district hospital in Malaysia and comparison with South East Asian Countries Kow, Ren Yi Low, Chooi Leng Jaya Kumar, Ruben Mustapha@Zakaria, Zaharul Azri Mor Japar Khan, Ed Simor Khan RD701 Orthopedics Introduction: Diabetic foot infection, a complication that is associated with lower-limb amputation, incurs a huge economic burden to the hospital and health care system of Malaysia. The bacteriological profile of pathogens in diabetic foot infections in Malaysia has been sparsely studied. We investigated the microbiology of diabetic foot infections in patients admitted to the district hospitals on the east coast of Malaysia. Methods: A retrospective analysis was conducted in three district hospitals (Hospital Kuala Lipis, Hospital Bentong and Hospital Raub) in Malaysia from 1st of January 2016 to 31st December 2016. The clinical specimens were cultured using Clinical and Laboratory Standards Institute (CLSI) guidelines. Antibiotic sensitivity testing to different antibiotics was carried out using the disc diffusion method. Result: A total of 188 pathogens were isolated from 173 patients, with an average of 1.09 pathogens per lesion. Majority of the pathogens isolated were gram negative pathogens (73.4%). The most commonly isolated pathogens were Staphylococcus aureus (17.5%). This was followed by Klebsiella spp. (17%), Pseudomonas spp. (15.4%) and Proteus spp. (13.8%). Gram positive pathogens were sensitive to most of the antibiotics tested except penicillin and fusidic acid. Gram negative pathogens were sensitive to all antibiotics tested except ampicillin and amoxicillin/clavulanic acid. Amikacin provide coverage for all gram negative pathogens in DFI. Conclusion: For the management of patient with infection in diabetic foot, the choice of antibiotic therapy depends on the sensitivity of the pathogens, the severity of the infection, the patient’s allergies history, toxicity and excretion of the antibiotics. Malaysian Medical Association 2019-06-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75101/1/7-Microbiology00214R1-1.pdf application/pdf en http://irep.iium.edu.my/75101/7/75101_Microbiology%20of%20diabetic%20foot%20infections%20in%20three%20district%20hospital%20in%20malaysia%20and%20comparison%20with%20south%20east%20asian%20countries_Scopus.pdf Kow, Ren Yi and Low, Chooi Leng and Jaya Kumar, Ruben and Mustapha@Zakaria, Zaharul Azri and Mor Japar Khan, Ed Simor Khan (2019) Microbiology of diabetic foot infections in three district hospital in Malaysia and comparison with South East Asian Countries. Medical Journal of Malaysia, 74 (5). pp. 400-405. ISSN 0300-5283 https://www.e-mjm.org/2019/v74n5/diabetic-foot-infections.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
RD701 Orthopedics |
| spellingShingle |
RD701 Orthopedics Kow, Ren Yi Low, Chooi Leng Jaya Kumar, Ruben Mustapha@Zakaria, Zaharul Azri Mor Japar Khan, Ed Simor Khan Microbiology of diabetic foot infections in three district hospital in Malaysia and comparison with South East Asian Countries |
| description |
Introduction: Diabetic foot infection, a complication that is
associated with lower-limb amputation, incurs a huge
economic burden to the hospital and health care system of
Malaysia. The bacteriological profile of pathogens in
diabetic foot infections in Malaysia has been sparsely
studied. We investigated the microbiology of diabetic foot
infections in patients admitted to the district hospitals on
the east coast of Malaysia.
Methods: A retrospective analysis was conducted in three
district hospitals (Hospital Kuala Lipis, Hospital Bentong
and Hospital Raub) in Malaysia from 1st of January 2016 to
31st December 2016. The clinical specimens were cultured
using Clinical and Laboratory Standards Institute (CLSI)
guidelines. Antibiotic sensitivity testing to different
antibiotics was carried out using the disc diffusion method.
Result: A total of 188 pathogens were isolated from 173
patients, with an average of 1.09 pathogens per lesion.
Majority of the pathogens isolated were gram negative
pathogens (73.4%). The most commonly isolated pathogens
were Staphylococcus aureus (17.5%). This was followed by
Klebsiella spp. (17%), Pseudomonas spp. (15.4%) and
Proteus spp. (13.8%). Gram positive pathogens were
sensitive to most of the antibiotics tested except penicillin
and fusidic acid. Gram negative pathogens were sensitive to
all antibiotics tested except ampicillin and
amoxicillin/clavulanic acid. Amikacin provide coverage for
all gram negative pathogens in DFI.
Conclusion: For the management of patient with infection in
diabetic foot, the choice of antibiotic therapy depends on the
sensitivity of the pathogens, the severity of the infection, the
patient’s allergies history, toxicity and excretion of the
antibiotics. |
| format |
Article |
| author |
Kow, Ren Yi Low, Chooi Leng Jaya Kumar, Ruben Mustapha@Zakaria, Zaharul Azri Mor Japar Khan, Ed Simor Khan |
| author_facet |
Kow, Ren Yi Low, Chooi Leng Jaya Kumar, Ruben Mustapha@Zakaria, Zaharul Azri Mor Japar Khan, Ed Simor Khan |
| author_sort |
Kow, Ren Yi |
| title |
Microbiology of diabetic foot infections in three district
hospital in Malaysia and comparison with South East
Asian Countries |
| title_short |
Microbiology of diabetic foot infections in three district
hospital in Malaysia and comparison with South East
Asian Countries |
| title_full |
Microbiology of diabetic foot infections in three district
hospital in Malaysia and comparison with South East
Asian Countries |
| title_fullStr |
Microbiology of diabetic foot infections in three district
hospital in Malaysia and comparison with South East
Asian Countries |
| title_full_unstemmed |
Microbiology of diabetic foot infections in three district
hospital in Malaysia and comparison with South East
Asian Countries |
| title_sort |
microbiology of diabetic foot infections in three district
hospital in malaysia and comparison with south east
asian countries |
| publisher |
Malaysian Medical Association |
| publishDate |
2019 |
| url |
http://irep.iium.edu.my/75101/ http://irep.iium.edu.my/75101/ http://irep.iium.edu.my/75101/1/7-Microbiology00214R1-1.pdf http://irep.iium.edu.my/75101/7/75101_Microbiology%20of%20diabetic%20foot%20infections%20in%20three%20district%20hospital%20in%20malaysia%20and%20comparison%20with%20south%20east%20asian%20countries_Scopus.pdf |
| first_indexed |
2023-09-18T21:46:16Z |
| last_indexed |
2023-09-18T21:46:16Z |
| _version_ |
1777413471066914816 |