Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines
Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM- B2 cell lines. We report here for the first time...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
Elsevier
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/9/75065%20%20%20%20%20Preliminary%20investigations%20of%20anti-cancer%20propertie.pdf http://irep.iium.edu.my/75065/8/75065%20Preliminary%20investigations%20of%20anti-cancer%20properties%20SCOPUS.pdf |
| Summary: | Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new
source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM-
B2 cell lines. We report here for the first time the anti-cancer potential of M. pendens on oral cancer cells derived from human
oral cavity, HSC-3 cell lines. MTT assay results showed that M. pendens crude extract markedly induced cytotoxicity on HSC-3
cell lines after 24 h (IC50 = 5 mg/mL) and 48 h (IC50 = 3 mg/ml). The apoptotic activity induced by M. pendens was detected in
HSC-3 cell lines by flow cytometry within 24 h. These results suggest that M. pendens may be a potential candidate for oral
cancer treatment |
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