Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
PURPOSE: To evaluate the susceptibility of microorganism causing early infection in open fractures to current antibiotic prophylaxis and determine contributing factors towards development of resistance. METHODS: A total of 110 cases of open fractures were selected in this study. They underwe...
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Malaysian Orthopaedic Association
2019
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| Online Access: | http://irep.iium.edu.my/74934/ http://irep.iium.edu.my/74934/ http://irep.iium.edu.my/74934/1/OPU06-etiological-pathogen-infection.pdf |
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iium-749342019-10-23T08:37:21Z http://irep.iium.edu.my/74934/ Microbiological study of etiological pathogen in early infection of open fracture in orthopedics Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri RD701 Orthopedics PURPOSE: To evaluate the susceptibility of microorganism causing early infection in open fractures to current antibiotic prophylaxis and determine contributing factors towards development of resistance. METHODS: A total of 110 cases of open fractures were selected in this study. They underwent routine debridement and C&S were followed up. Risk factors to antibiotic resistance were identified. RESULTS: Admission to ICU, blood transfusion, antibiotic regime and duration, fracture grade, injury severity score and duration of admission were significantly associated with resistance of microorganism. There was Gram-negative predominance of 65.9%. The overall resistance to Cefuroxime was 68.6% and 36.9% to Gentamicin. Staphyloccoccus aureus and MRSA were the commonest Gram-positive while Pseudomonas and Acinetobacter Gram-negative. DISCUSSIONS: Resistance in open fracture is not well established unlike rate of infection. Previous studies reported predominant Gram-postive microorganisms which form the basis of prophylactic antibiotics1 . Hannigan et al. reported increasing multi-drug resistance bacterias in open fractures2 . Carsenti-Etesse et al. reported resistance was influenced by type and duration of antibiotics while others have described various other factors3 . CONCLUSION: The high resistance of microorganisms and shift to predominantly Gram-negative microorganisms is alarming. Further measures are needed to achieve optimal outcome. REFERENCES: 1. Gustilo, R.B., (1971). Management of open fractures. An analysis of 673 cases. Minnesota Medicine, 54(3), pp.185–189 2. Hannigan, G.D. et al., 2014. Cultureindependent pilot study of microbiota colonizing open fractures and association. Journal of Orthopaedic Research, 32( Malaysian Orthopaedic Association 2019-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74934/1/OPU06-etiological-pathogen-infection.pdf Tai, Ken Meng and Sulong, Ahmad Fadzli and Mohd Yusof, Nazri (2019) Microbiological study of etiological pathogen in early infection of open fracture in orthopedics. Malaysian Orthopaedic Jornal, 13 (Supplement A). ISSN 1985-2533 E-ISSN 2232-111X https://www.morthoj.org/supplements/moa-2019/index.php |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RD701 Orthopedics |
| spellingShingle |
RD701 Orthopedics Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri Microbiological study of etiological pathogen in early infection of open fracture in orthopedics |
| description |
PURPOSE:
To evaluate the susceptibility of microorganism
causing early infection in open fractures to
current antibiotic prophylaxis and determine
contributing factors towards development of
resistance.
METHODS:
A total of 110 cases of open fractures were
selected in this study. They underwent routine
debridement and C&S were followed up. Risk
factors to antibiotic resistance were identified.
RESULTS:
Admission to ICU, blood transfusion, antibiotic
regime and duration, fracture grade, injury
severity score and duration of admission were
significantly associated with resistance of
microorganism. There was Gram-negative
predominance of 65.9%. The overall resistance to
Cefuroxime was 68.6% and 36.9% to
Gentamicin. Staphyloccoccus aureus and MRSA
were the commonest Gram-positive while
Pseudomonas and Acinetobacter Gram-negative.
DISCUSSIONS:
Resistance in open fracture is not well
established unlike rate of infection. Previous
studies reported predominant Gram-postive
microorganisms which form the basis of
prophylactic antibiotics1
. Hannigan et al. reported
increasing multi-drug resistance bacterias in open
fractures2
. Carsenti-Etesse et al. reported
resistance was influenced by type and duration of
antibiotics while others have described various
other factors3
.
CONCLUSION:
The high resistance of microorganisms and shift
to predominantly Gram-negative microorganisms
is alarming. Further measures are needed to
achieve optimal outcome.
REFERENCES:
1. Gustilo, R.B., (1971). Management of
open fractures. An analysis of 673 cases.
Minnesota Medicine, 54(3), pp.185–189
2. Hannigan, G.D. et al., 2014. Cultureindependent pilot study of microbiota
colonizing open fractures and association.
Journal of Orthopaedic Research, 32( |
| format |
Article |
| author |
Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri |
| author_facet |
Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri |
| author_sort |
Tai, Ken Meng |
| title |
Microbiological study of etiological pathogen in early infection
of open fracture in orthopedics |
| title_short |
Microbiological study of etiological pathogen in early infection
of open fracture in orthopedics |
| title_full |
Microbiological study of etiological pathogen in early infection
of open fracture in orthopedics |
| title_fullStr |
Microbiological study of etiological pathogen in early infection
of open fracture in orthopedics |
| title_full_unstemmed |
Microbiological study of etiological pathogen in early infection
of open fracture in orthopedics |
| title_sort |
microbiological study of etiological pathogen in early infection
of open fracture in orthopedics |
| publisher |
Malaysian Orthopaedic Association |
| publishDate |
2019 |
| url |
http://irep.iium.edu.my/74934/ http://irep.iium.edu.my/74934/ http://irep.iium.edu.my/74934/1/OPU06-etiological-pathogen-infection.pdf |
| first_indexed |
2023-09-18T21:46:02Z |
| last_indexed |
2023-09-18T21:46:02Z |
| _version_ |
1777413456354344960 |