Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats

Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present...

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Main Authors:	Hashim Fauzy, Fatimatuzzahra, Mohd Zainudin, Maizura, Ismawi, Hidayatul Radziah, F T Elshami, Taher
Format:	Article
Language:	English English
Published:	Hindawi 2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/2/Piper%20sarmentosum%20leaves%20aqueos.pdf http://irep.iium.edu.my/74326/8/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract%20Attenuates%20Vascular%20Endothelial%20Dysfunction%20in%20Spontaneously%20Hypertensive%20Rats_Scopus.pdf

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spelling	iium-743262020-01-02T18:35:56Z http://irep.iium.edu.my/74326/ Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher R Medicine (General) Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures () of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level () and reduced endothelin-1 (ET-1) level () in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production. Hindawi 2019-08-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74326/2/Piper%20sarmentosum%20leaves%20aqueos.pdf application/pdf en http://irep.iium.edu.my/74326/8/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract%20Attenuates%20Vascular%20Endothelial%20Dysfunction%20in%20Spontaneously%20Hypertensive%20Rats_Scopus.pdf Hashim Fauzy, Fatimatuzzahra and Mohd Zainudin, Maizura and Ismawi, Hidayatul Radziah and F T Elshami, Taher (2019) Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats. Evidence-Based Complementary and Alternative Medicine, Volume 2019. pp. 1-8. ISSN 1741-427X E-ISSN 1741-4288 https://www.hindawi.com/journals/ecam/2019/7198592/ https://doi.org/10.1155/2019/7198592
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
description	Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures () of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level () and reduced endothelin-1 (ET-1) level () in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.
format	Article
author	Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher
author_facet	Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher
author_sort	Hashim Fauzy, Fatimatuzzahra
title	Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
title_short	Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
title_full	Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
title_fullStr	Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
title_full_unstemmed	Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
title_sort	piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
publisher	Hindawi
publishDate	2019
url	http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/2/Piper%20sarmentosum%20leaves%20aqueos.pdf http://irep.iium.edu.my/74326/8/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract%20Attenuates%20Vascular%20Endothelial%20Dysfunction%20in%20Spontaneously%20Hypertensive%20Rats_Scopus.pdf
first_indexed	2023-09-18T21:45:18Z
last_indexed	2023-09-18T21:45:18Z
_version_	1777413409356120064

Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats

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