Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme

Inhibition of xanthine oxidase (XO) activity is an effective therapeutic approach for the treatment of diseases such as gout and hyperuricemia. Additionally, the use of XO inhibitors can further be extended to injury treatments such as ischemic reperfusion in various organs such as heart, liver and...

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Main Authors:	Rullah, Kamal, Khye, Saw Phin, Ang, Serene, Mohd Aluwi, Mohd Fadhlizil Fasihi, Lam, Kok Wai
Format:	Article
Language:	Malay
Published:	UKM Press 2018
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/74216/ http://irep.iium.edu.my/74216/ http://irep.iium.edu.my/74216/ http://irep.iium.edu.my/74216/1/Kamal%20Rullah%2016.pdf

id	iium-74216
recordtype	eprints
spelling	iium-742162019-09-19T07:12:26Z http://irep.iium.edu.my/74216/ Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme Rullah, Kamal Khye, Saw Phin Ang, Serene Mohd Aluwi, Mohd Fadhlizil Fasihi Lam, Kok Wai RS403 Materia Medica-Pharmaceutical Chemistry Inhibition of xanthine oxidase (XO) activity is an effective therapeutic approach for the treatment of diseases such as gout and hyperuricemia. Additionally, the use of XO inhibitors can further be extended to injury treatments such as ischemic reperfusion in various organs such as heart, liver and kidney. In this study, 7 aurone compounds were synthesized and tested on XO and compared with the positive control allopurinol. Compound 5e was identified as the most potent compound and was able to inhibit half of XO activity at 33.23 μM followed by compounds 5f and 5d at 210.22 μM and 302.0 μM, respectively. Finally, molecular docking study was conducted to understand the important binding interactions of the selected aurone with the active site of XO. UKM Press 2018 Article PeerReviewed application/pdf ms http://irep.iium.edu.my/74216/1/Kamal%20Rullah%2016.pdf Rullah, Kamal and Khye, Saw Phin and Ang, Serene and Mohd Aluwi, Mohd Fadhlizil Fasihi and Lam, Kok Wai (2018) Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme. Jurnal Sains Kesihatan Malaysia (JSKM), 16 (1). pp. 135-143. ISSN 2289-4535 http://ejournal.ukm.my/jskm/article/view/18825/7406 10.17576/JSKM-2018-1601-17
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	Malay
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Rullah, Kamal Khye, Saw Phin Ang, Serene Mohd Aluwi, Mohd Fadhlizil Fasihi Lam, Kok Wai Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
description	Inhibition of xanthine oxidase (XO) activity is an effective therapeutic approach for the treatment of diseases such as gout and hyperuricemia. Additionally, the use of XO inhibitors can further be extended to injury treatments such as ischemic reperfusion in various organs such as heart, liver and kidney. In this study, 7 aurone compounds were synthesized and tested on XO and compared with the positive control allopurinol. Compound 5e was identified as the most potent compound and was able to inhibit half of XO activity at 33.23 μM followed by compounds 5f and 5d at 210.22 μM and 302.0 μM, respectively. Finally, molecular docking study was conducted to understand the important binding interactions of the selected aurone with the active site of XO.
format	Article
author	Rullah, Kamal Khye, Saw Phin Ang, Serene Mohd Aluwi, Mohd Fadhlizil Fasihi Lam, Kok Wai
author_facet	Rullah, Kamal Khye, Saw Phin Ang, Serene Mohd Aluwi, Mohd Fadhlizil Fasihi Lam, Kok Wai
author_sort	Rullah, Kamal
title	Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
title_short	Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
title_full	Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
title_fullStr	Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
title_full_unstemmed	Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
title_sort	synthesis, biological evaluation and docking studies of aurone derivatives on xanthine oxidase enzyme
publisher	UKM Press
publishDate	2018
url	http://irep.iium.edu.my/74216/ http://irep.iium.edu.my/74216/ http://irep.iium.edu.my/74216/ http://irep.iium.edu.my/74216/1/Kamal%20Rullah%2016.pdf
first_indexed	2023-09-18T21:45:08Z
last_indexed	2023-09-18T21:45:08Z
_version_	1777413399275110400

Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme

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