Suppression of PGE2 production via disruption of MAPK
phosphorylation by unsymmetrical dicarbonyl curcumin
derivatives

Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives

Curcumin is an important molecule found in turmeric plants and has been reported to exhibit some profound anti-inflammatory activities by interacting with several important molecular targets found in the mitogenactivated protein kinase and NF-κβ pathways. As part of our continuing effort to search f...

Full description

Bibliographic Details
Main Authors:	Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Haque, Md. Areeful, Yamin, Bohari M., Ahmad, Waqas, Amjad, Muhammad Wahab, Leong, Sze Wei, Fahmizar, Nurul Amira, Jalil, Juriyati, Abas, Faridah, Ismail, Nor Hadiani, Jantan, Ibrahim, Lam, Kok Wai
Format:	Article
Language:	English
Published:	SpringerLink 2017
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/74211/ http://irep.iium.edu.my/74211/ http://irep.iium.edu.my/74211/ http://irep.iium.edu.my/74211/7/74211%20Suppression%20of%20PGE.pdf

Similar Items

Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
by: Rullah, Kamal, et al.
Published: (2019)

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2016)

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
by: Rullah, Malaysia, et al.
Published: (2019)

Design of unsymmetrical fed patch UWB antenna with unsymmetrical slotted ground
by: Islam, Md. Rafiqul, et al.
Published: (2011)

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
by: Poh, Yen Khor, et al.
Published: (2019)

U-shaped planer UWB antenna with unsymmetrical feed
by: Alam, A. H. M. Zahirul, et al.
Published: (2011)

Tuning fork UWB antenna with unsymmetrical feed line
by: Alam, A. H. M. Zahirul, et al.
Published: (2012)

Analysis of phosphorylation sites of protein kinases in Cryptosporidium
by: Barudin, Mohd Aiman, et al.
Published: (2018)

Synergistic effects of GSK3 and p38 MAPK inhibitors on growth of Plasmodium falciparum ex vivo
by: Marhalim, L., et al.
Published: (2014)

Phosphorylated orange adsorption gel for removal of selected heavy metals
by: Tew, Seow Ting
Published: (2012)

Tuning the photochemical properties of unsymmetrical functionalized dimethylaminobenzaldehyde diethylenetriamine / Salamiah Zakaria … [et al.]
by: Zakaria, Salamiah, et al.
Published: (2016)

Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones
by: Rullah, Kamal, et al.
Published: (2019)

In silico study of the ErbB4 interactions with curcumin analogs
by: Azman, Putri Arsyadian, et al.
Published: (2015)

Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
by: Semail, Sulawati, et al.
Published: (2011)

Atherosclerosis: Curcumin againts heated palm oil diet in ovariectomized rats
by: Aziz NUA,, et al.
Published: (2011)

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation
by: Kamato, Danielle, et al.
Published: (2013)

Theory and derivation of unsymmetrical rotor equation of the foil-air bearing rotor system and its validation with experiment data
by: M. F., Hassan
Published: (2019)

Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
by: Kamal, Rullah, et al.
Published: (2014)

Boron removal from aqueous solution using curcumin-impregnated activated carbon
by: Azhar Abdul Halim,, et al.
Published: (2013)

Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
by: Zahidah, A.F, et al.
Published: (2012)

Size and stability of curcumin niosomes from combinations of Tween 80 and Span 80
by: Masrina Mohd Nadzir,, et al.
Published: (2017)

Alkaline-based curcumin extraction from selected zingiberaceae for antimicrobial and antioxidant activities
by: Othman, Rashidi, et al.
Published: (2019)

Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
by: Rullah, Kamal, et al.
Published: (2015)

Sintesis, penilaian biologi dan kajian dok sebatian auron ke atas enzim xantin oksidase
by: Lam, Kok Wai, et al.
Published: (2018)

Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
by: Rullah, Kamal, et al.
Published: (2018)

Effect of thermoplastic polyurethane (TPU) on the thermal and mechanical properties of polylactic acid (PLA)/ curcumin blends
by: Syed Shaharuddin, Sharifah Imihezri, et al.
Published: (2018)

Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA
by: Rullah, Kamal, et al.
Published: (2019)

A Proanthocyanidin From Cinnamomum Zeylanicum Stimulates Phosphorylation Of Insulin Receptor In 3T3–L1 Adipocytes
by: Bakhtiar, M. Taher, et al.
Published: (2006)

Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells
by: Kamato, Danielle, et al.
Published: (2014)

Role of Phosphorylated insulin-like growth factor binding protein-1(Phigfbp-1) in prediction of preterm delivery
by: Mat Desa, Norliza, et al.
Published: (2013)

Effect of curcumin on the aorta of experimental ovariectomized rats fed with 2% cholesterol diet: An electron microscopic study
by: Ab Rashid J,, et al.
Published: (2011)

Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2016)

Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells
by: Little, Peter J., et al.
Published: (2013)

Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2
by: Rostam, Muhamad Ashraf, et al.
Published: (2018)

Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture
by: Chia, Ling Li, et al.
Published: (2016)

Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway
by: Huq, AKM Moyeenul, et al.
Published: (2019)

Inclusion of curcumin in β-cyclodextrins as potential drug delivery system: preparation, characterization and its preliminary cytotoxicity approaches
by: Muhammad Hasnor Ja'far,, et al.
Published: (2018)

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2006)

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle
by: Rostam, Muhamad Ashraf, et al.
Published: (2016)

Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway
by: Muhammad Nazirul Mubin, Aziz, et al.
Published: (2018)

Cannot write session to /tmp/vufind_sessions/sess_clp4fqlscgbf7mai4p6ndlodmd