Calcium phosphate /poly (ethylene glycol) bone cement: cell culture performance
Calcium phosphate cement (CPC) for injectable bone cement application has been developed in this study. The CPC was produced using a novel wet chemical precipitation method derived hydroxyapatite (HA) powder. The calcium and phosphorus precursors used to synthesize HA powder were calcium hydrox...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Blue Eyes Intelligence Engineering and Sciences Publication
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/73879/ http://irep.iium.edu.my/73879/ http://irep.iium.edu.my/73879/1/73879_Calcium%20phosphate%20poly_article.pdf http://irep.iium.edu.my/73879/2/73879_Calcium%20phosphate%20poly_scopus.pdf |
| Summary: | Calcium phosphate cement (CPC) for injectable
bone cement application has been developed in this study. The
CPC was produced using a novel wet chemical precipitation
method derived hydroxyapatite (HA) powder. The calcium and
phosphorus precursors used to synthesize HA powder were
calcium hydroxide, Ca(OH)2
, and di-ammonium hydrogen
phosphate, (NH4
)2HPO4
. The HA powder was mixed with distilled
water at certain powder-to-liquid (P/L) ratios. In this study, the
P/L ratios were varied at 1.3 and 1.7. PEG was added into CPC
with the P/L ratio of 1.3, and it was adjusted at 1 and 5 wt%. The
results of this study revealed that higher P/L ratio contributed to
the decreased in porosity of CPC. Meanwhile, the addition of
PEG increased the porosity of CPC. This is significant for cells
adhesion and proliferation, such that cell proliferate faster and
better adhesion with the incorporation of PEG into CPC. The cell
culture on CPC has proven that the fabricated CPC shows no
toxic reaction and cells grow well. |
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