The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to eva...
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iium-737662020-02-05T07:58:56Z http://irep.iium.edu.my/73766/ The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats Mustafa Al-Ahmad, Basma Ezzat Dally, Imad Matloub Abired, Ahmed N. Saad, Azzubaidi Marwan Emad, Mohamad Nafie R Medicine (General) Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin(STZ)-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into five groups of 8 animals each: Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level and liver enzymes were determined in all experimental rats. Results showed a significantly increased relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased body weight, total protein, albumin, and globulin levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups, however, the ameliorative effect was significant in DG group only (p<0.05). These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. In conclusion, our data showed that flaxseed extract represents a potential alternative treatment to control diabetes mellitus and its related hepatopathy 2019-07-31 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73766/1/73766_The%20effect%20of%20flax%20seed%20extract.pdf Mustafa Al-Ahmad, Basma Ezzat and Dally, Imad Matloub and Abired, Ahmed N. and Saad, Azzubaidi Marwan and Emad, Mohamad Nafie (2019) The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats. World Journal of Pharmacy and Pharmaceutical Sciences, 8 (8). pp. 780-798. ISSN 2278 – 4357 |
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International Islamic University Malaysia |
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Online Access |
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English |
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R Medicine (General) |
| spellingShingle |
R Medicine (General) Mustafa Al-Ahmad, Basma Ezzat Dally, Imad Matloub Abired, Ahmed N. Saad, Azzubaidi Marwan Emad, Mohamad Nafie The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats |
| description |
Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to evaluate the hepatoprotective effects of flaxseed extract
in streptozotocin(STZ)-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into
five groups of 8 animals each: Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with
glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level and liver enzymes were determined in all experimental rats. Results showed a significantly increased relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased
body weight, total protein, albumin, and globulin levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups, however, the ameliorative effect was significant in DG group only (p<0.05). These
pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats.
In conclusion, our data showed that flaxseed extract represents a potential alternative treatment to control diabetes mellitus and its related hepatopathy |
| format |
Article |
| author |
Mustafa Al-Ahmad, Basma Ezzat Dally, Imad Matloub Abired, Ahmed N. Saad, Azzubaidi Marwan Emad, Mohamad Nafie |
| author_facet |
Mustafa Al-Ahmad, Basma Ezzat Dally, Imad Matloub Abired, Ahmed N. Saad, Azzubaidi Marwan Emad, Mohamad Nafie |
| author_sort |
Mustafa Al-Ahmad, Basma Ezzat |
| title |
The effect of flax seed extract on the blood glucose
level and liver bio markers in diabetic rats |
| title_short |
The effect of flax seed extract on the blood glucose
level and liver bio markers in diabetic rats |
| title_full |
The effect of flax seed extract on the blood glucose
level and liver bio markers in diabetic rats |
| title_fullStr |
The effect of flax seed extract on the blood glucose
level and liver bio markers in diabetic rats |
| title_full_unstemmed |
The effect of flax seed extract on the blood glucose
level and liver bio markers in diabetic rats |
| title_sort |
effect of flax seed extract on the blood glucose
level and liver bio markers in diabetic rats |
| publishDate |
2019 |
| url |
http://irep.iium.edu.my/73766/ http://irep.iium.edu.my/73766/1/73766_The%20effect%20of%20flax%20seed%20extract.pdf |
| first_indexed |
2023-09-18T21:44:35Z |
| last_indexed |
2023-09-18T21:44:35Z |
| _version_ |
1777413365135572992 |