Paraoxonase activity in healthy population of major ethnic groups

Ischaemic heart disease (IHD) is one of the leading causes of mortality globally with varying risk across different ethnic groups. Recent evidence has suggested a role for paraoxonase, an high density lipoprotein (HDL)associated enzyme in the prevention of atherosclerosis by inhibiting the oxidative...

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Main Authors:	Abdullah, Nor Zamzila, Sirajudeen, K. N. S, Nadiger, H. A
Format:	Book
Language:	English
Published:	IIUM Press, International Islamic University Malaysia 2017
Subjects:	QP Physiology R Medicine (General) RA Public aspects of medicine
Online Access:	http://irep.iium.edu.my/73664/ http://irep.iium.edu.my/73664/1/73664_Paraoxonase%20activity%20in%20healthy%20population%20of%20major%20ethnic%20groups.pdf

id	iium-73664
recordtype	eprints
spelling	iium-736642019-11-04T02:44:31Z http://irep.iium.edu.my/73664/ Paraoxonase activity in healthy population of major ethnic groups Abdullah, Nor Zamzila Sirajudeen, K. N. S Nadiger, H. A QP Physiology R Medicine (General) RA Public aspects of medicine Ischaemic heart disease (IHD) is one of the leading causes of mortality globally with varying risk across different ethnic groups. Recent evidence has suggested a role for paraoxonase, an high density lipoprotein (HDL)associated enzyme in the prevention of atherosclerosis by inhibiting the oxidative modification of low density lipoprotein (LDL). Genetic polymorphism in paraoxonase 1 (PON1) gene (Arg192 and Gln192) with varying abilities to degrade oxidized LDL is being implicated as one of the risk factors for IHD. The distribution of PON1 polymorphic forms has been found to differ among the ethnic groups but conflicting results have been reported regarding their association with IHD risk. Indians, compared to other ethnic groups have been reported to carry a higher risk of IHD but the risk factors are still not well understood. In Malaysia, the existence of three separate ethnic groups with varying IHD incidence provides an ideal opportunity to carry out this study. The purpose of this study were to find out the PON1 activities, the phenotypic polymorphism of PON1 and the level of lipid profiles among the three major ethnic groups in Malaysia and their association with varying IHD risk among them. A prospective pilot study was carried out on a total number of 150 healthy volunteers who fulfilled the inclusion and exclusion criteria from September 2003 until July 2004. IIUM Press, International Islamic University Malaysia 2017 Book PeerReviewed application/pdf en http://irep.iium.edu.my/73664/1/73664_Paraoxonase%20activity%20in%20healthy%20population%20of%20major%20ethnic%20groups.pdf Abdullah, Nor Zamzila and Sirajudeen, K. N. S and Nadiger, H. A (2017) Paraoxonase activity in healthy population of major ethnic groups. IIUM Press, International Islamic University Malaysia, Kuala Lumpur, Malaysia. ISBN 978-967-418-730-9
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology R Medicine (General) RA Public aspects of medicine
spellingShingle	QP Physiology R Medicine (General) RA Public aspects of medicine Abdullah, Nor Zamzila Sirajudeen, K. N. S Nadiger, H. A Paraoxonase activity in healthy population of major ethnic groups
description	Ischaemic heart disease (IHD) is one of the leading causes of mortality globally with varying risk across different ethnic groups. Recent evidence has suggested a role for paraoxonase, an high density lipoprotein (HDL)associated enzyme in the prevention of atherosclerosis by inhibiting the oxidative modification of low density lipoprotein (LDL). Genetic polymorphism in paraoxonase 1 (PON1) gene (Arg192 and Gln192) with varying abilities to degrade oxidized LDL is being implicated as one of the risk factors for IHD. The distribution of PON1 polymorphic forms has been found to differ among the ethnic groups but conflicting results have been reported regarding their association with IHD risk. Indians, compared to other ethnic groups have been reported to carry a higher risk of IHD but the risk factors are still not well understood. In Malaysia, the existence of three separate ethnic groups with varying IHD incidence provides an ideal opportunity to carry out this study. The purpose of this study were to find out the PON1 activities, the phenotypic polymorphism of PON1 and the level of lipid profiles among the three major ethnic groups in Malaysia and their association with varying IHD risk among them. A prospective pilot study was carried out on a total number of 150 healthy volunteers who fulfilled the inclusion and exclusion criteria from September 2003 until July 2004.
format	Book
author	Abdullah, Nor Zamzila Sirajudeen, K. N. S Nadiger, H. A
author_facet	Abdullah, Nor Zamzila Sirajudeen, K. N. S Nadiger, H. A
author_sort	Abdullah, Nor Zamzila
title	Paraoxonase activity in healthy population of major ethnic groups
title_short	Paraoxonase activity in healthy population of major ethnic groups
title_full	Paraoxonase activity in healthy population of major ethnic groups
title_fullStr	Paraoxonase activity in healthy population of major ethnic groups
title_full_unstemmed	Paraoxonase activity in healthy population of major ethnic groups
title_sort	paraoxonase activity in healthy population of major ethnic groups
publisher	IIUM Press, International Islamic University Malaysia
publishDate	2017
url	http://irep.iium.edu.my/73664/ http://irep.iium.edu.my/73664/1/73664_Paraoxonase%20activity%20in%20healthy%20population%20of%20major%20ethnic%20groups.pdf
first_indexed	2023-09-18T21:44:26Z
last_indexed	2023-09-18T21:44:26Z
_version_	1777413354927685632

Paraoxonase activity in healthy population of major ethnic groups

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