Cytomegalovirus impact on elderlies’ vaccination response
Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to chang...
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| Language: | English |
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IIUM Press, International Islamic University Malaysia
2017
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| Online Access: | http://irep.iium.edu.my/73540/ http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf |
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iium-735402019-10-21T06:40:09Z http://irep.iium.edu.my/73540/ Cytomegalovirus impact on elderlies’ vaccination response Abdull Jalil, Mohd Asyraf Mohd Yusof, Nazri QR Microbiology Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to change the immune system in similar ways to aging, by causing chronic antigenic stress. However, direct evidence on the impact of such changes on health remains contentious due to limited data, variable population backgrounds and individual responses to HCMV. In this study among 59 elderly people in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on immunosenescence was assessed using Influenza vaccination response via haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and history of significant infection was also studied as contributing factors. It was found that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010). IIUM Press, International Islamic University Malaysia 2017 Book PeerReviewed application/pdf en http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf Abdull Jalil, Mohd Asyraf and Mohd Yusof, Nazri (2017) Cytomegalovirus impact on elderlies’ vaccination response. IIUM Press, International Islamic University Malaysia, Kuala Lumpur, Malaysia. ISBN 978-967-418-712-5 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
QR Microbiology |
| spellingShingle |
QR Microbiology Abdull Jalil, Mohd Asyraf Mohd Yusof, Nazri Cytomegalovirus impact on elderlies’ vaccination response |
| description |
Disease burden from the Malaysian elderly population is increasing as demographics
shifts towards longer life expectancy. It is increasingly evident that immunosenescence
is the central process in many age-related illnesses. Latent human cytomegalovirus
(HCMV) infection had been shown to change the immune system in similar ways to
aging, by causing chronic antigenic stress. However, direct evidence on the impact of
such changes on health remains contentious due to limited data, variable population
backgrounds and individual responses to HCMV. In this study among 59 elderly people
in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on
immunosenescence was assessed using Influenza vaccination response via
haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre
of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and
history of significant infection was also studied as contributing factors. It was found
that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower
response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010). |
| format |
Book |
| author |
Abdull Jalil, Mohd Asyraf Mohd Yusof, Nazri |
| author_facet |
Abdull Jalil, Mohd Asyraf Mohd Yusof, Nazri |
| author_sort |
Abdull Jalil, Mohd Asyraf |
| title |
Cytomegalovirus impact on elderlies’ vaccination response |
| title_short |
Cytomegalovirus impact on elderlies’ vaccination response |
| title_full |
Cytomegalovirus impact on elderlies’ vaccination response |
| title_fullStr |
Cytomegalovirus impact on elderlies’ vaccination response |
| title_full_unstemmed |
Cytomegalovirus impact on elderlies’ vaccination response |
| title_sort |
cytomegalovirus impact on elderlies’ vaccination response |
| publisher |
IIUM Press, International Islamic University Malaysia |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/73540/ http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf |
| first_indexed |
2023-09-18T21:44:16Z |
| last_indexed |
2023-09-18T21:44:16Z |
| _version_ |
1777413344477577216 |