Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
The present study aimed to characterize and investigate 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one (22) as a novel selective COX-2 inhibitor. The data collected from the single X-ray crystallographic analysis and in silico study provide important insights on the molecular...
Main Authors: | Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, M.Yamin, Bohari, Baharuddin, Mohd Syukri, Ismail, Nor Hadiani, YudaTeruna, Hilwan, Abbas Bukhari, Syed Nasir, Jantan, Ibrahim, Jalil, Juriyati, Husain, Khairana, Lam, Kok Wai |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/73535/ http://irep.iium.edu.my/73535/ http://irep.iium.edu.my/73535/ http://irep.iium.edu.my/73535/1/Kamal%20Rullah%204.pdf |
Similar Items
-
Crystal structure of (E)-2-(4-hydroxy-3-methoxybenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one, C19H18O4
by: El-Sayed, Nahed Nasser Eid, et al.
Published: (2016) -
Crystal Structure of 4-({(1E,2E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]allylidene}amino)1H-1,2,4-triazole-5(4H)-thione
by: Kulkarni, Ajaykumar D., et al.
Published: (2015) -
Synthesis, characterization and antioxidant activity of 3-(2-Amino-1,3-Selenazol-4-yl)-2H-Chromen-2-Ones derivatives
by: Nurul Zawani Alias,, et al.
Published: (2018) -
Crystal Structure of 4-({(1E,2E)-3-[3-(4-fluorophenyl)-1-
isopropyl-1H-indol-2-yl]allylidene}amino)-5-methyl-1H-1,2,4-triazole-5(4H)-thione
by: Kulkarni, Ajaykumar D., et al.
Published: (2015) -
Novel sulfonamide derivatives carrying a biologically active 3,4-dimethoxyphenyl moiety as VEGFR-2 inhibitors
by: Ghorab, Mostafa Mohammed, et al.
Published: (2016)