Proteomic profiles of young adults with acute myocardial infarction

Introduction: Proteomic profiling is essential in understanding the pathophysiological process of multifactorial diseases such as acute myocardial infarction (AMI). Despite the increasing incidence of AMI in young adults, proteomic-based study focusing on young AMI remains limited. This study aimed...

Full description

Bibliographic Details
Main Authors:	Mohamed Bakrim, Norbaiyah, Mohd Shah, Azarisman Shah, A.Talib, Norlelawati, Ab Rahman, Jamalludin, Muhamad Bunnori, Noraslinda, Idorus, Mohd Yusri, Zainal Abidin, Siti Khairani, Abdullah, Aszrin
Format:	Article
Language:	English English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia 2019
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/73485/ http://irep.iium.edu.my/73485/ http://irep.iium.edu.my/73485/1/73485_Proteomic%20Profiles%20of%20Young%20Adults%20with%20Acute.pdf http://irep.iium.edu.my/73485/2/73485_Proteomic%20Profiles%20of%20Young%20Adults%20with%20Acute_WOS.pdf

id	iium-73485
recordtype	eprints
spelling	iium-734852020-03-19T04:15:06Z http://irep.iium.edu.my/73485/ Proteomic profiles of young adults with acute myocardial infarction Mohamed Bakrim, Norbaiyah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Ab Rahman, Jamalludin Muhamad Bunnori, Noraslinda Idorus, Mohd Yusri Zainal Abidin, Siti Khairani Abdullah, Aszrin R Medicine (General) RB Pathology Introduction: Proteomic profiling is essential in understanding the pathophysiological process of multifactorial diseases such as acute myocardial infarction (AMI). Despite the increasing incidence of AMI in young adults, proteomic-based study focusing on young AMI remains limited. This study aimed to examine the plasma proteomic profiles of young adults with AMI compared to control subjects. We also hope to identify disease-specific protein biomarkers that contribute to the development of AMI in the young. Methods: Pooled plasma protein from 10 AMI patients aged 18 to 45 years and 10 age, gender and racematched volunteers were separated using two-dimensional electrophoresis (2-DE). The spots proteins were analysed using the PD Quest analysis software. The spots proteins that were found to have been expressed differently between the two groups were identified by Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry. Results: There were three differently expressed proteins namely Apolipoprotein AI (Apo AI), Apolipoprotein AIV (Apo AIV) and Haptoglobin (p < 0.05). The expressions of these proteins were found to be increased in young patients with AMI compared to control subjects. Conclusion: The up regulation of Apo AI, Apo AIV and Haptoglobin in AMI patients indicate their important roles in the development of atherosclerotic disease. Thus, Apo AI, Apo AIV and Haptoglobin are potential disease biomarkers for young AMI. Kulliyyah of Medicine, International Islamic University Malaysia 2019-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73485/1/73485_Proteomic%20Profiles%20of%20Young%20Adults%20with%20Acute.pdf application/pdf en http://irep.iium.edu.my/73485/2/73485_Proteomic%20Profiles%20of%20Young%20Adults%20with%20Acute_WOS.pdf Mohamed Bakrim, Norbaiyah and Mohd Shah, Azarisman Shah and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Muhamad Bunnori, Noraslinda and Idorus, Mohd Yusri and Zainal Abidin, Siti Khairani and Abdullah, Aszrin (2019) Proteomic profiles of young adults with acute myocardial infarction. International Medical Journal Malaysia, 18 (3). pp. 113-119. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_18_no_3/Vol18No3-103-110.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Mohamed Bakrim, Norbaiyah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Ab Rahman, Jamalludin Muhamad Bunnori, Noraslinda Idorus, Mohd Yusri Zainal Abidin, Siti Khairani Abdullah, Aszrin Proteomic profiles of young adults with acute myocardial infarction
description	Introduction: Proteomic profiling is essential in understanding the pathophysiological process of multifactorial diseases such as acute myocardial infarction (AMI). Despite the increasing incidence of AMI in young adults, proteomic-based study focusing on young AMI remains limited. This study aimed to examine the plasma proteomic profiles of young adults with AMI compared to control subjects. We also hope to identify disease-specific protein biomarkers that contribute to the development of AMI in the young. Methods: Pooled plasma protein from 10 AMI patients aged 18 to 45 years and 10 age, gender and racematched volunteers were separated using two-dimensional electrophoresis (2-DE). The spots proteins were analysed using the PD Quest analysis software. The spots proteins that were found to have been expressed differently between the two groups were identified by Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry. Results: There were three differently expressed proteins namely Apolipoprotein AI (Apo AI), Apolipoprotein AIV (Apo AIV) and Haptoglobin (p < 0.05). The expressions of these proteins were found to be increased in young patients with AMI compared to control subjects. Conclusion: The up regulation of Apo AI, Apo AIV and Haptoglobin in AMI patients indicate their important roles in the development of atherosclerotic disease. Thus, Apo AI, Apo AIV and Haptoglobin are potential disease biomarkers for young AMI.
format	Article
author	Mohamed Bakrim, Norbaiyah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Ab Rahman, Jamalludin Muhamad Bunnori, Noraslinda Idorus, Mohd Yusri Zainal Abidin, Siti Khairani Abdullah, Aszrin
author_facet	Mohamed Bakrim, Norbaiyah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Ab Rahman, Jamalludin Muhamad Bunnori, Noraslinda Idorus, Mohd Yusri Zainal Abidin, Siti Khairani Abdullah, Aszrin
author_sort	Mohamed Bakrim, Norbaiyah
title	Proteomic profiles of young adults with acute myocardial infarction
title_short	Proteomic profiles of young adults with acute myocardial infarction
title_full	Proteomic profiles of young adults with acute myocardial infarction
title_fullStr	Proteomic profiles of young adults with acute myocardial infarction
title_full_unstemmed	Proteomic profiles of young adults with acute myocardial infarction
title_sort	proteomic profiles of young adults with acute myocardial infarction
publisher	Kulliyyah of Medicine, International Islamic University Malaysia
publishDate	2019
url	http://irep.iium.edu.my/73485/ http://irep.iium.edu.my/73485/ http://irep.iium.edu.my/73485/1/73485_Proteomic%20Profiles%20of%20Young%20Adults%20with%20Acute.pdf http://irep.iium.edu.my/73485/2/73485_Proteomic%20Profiles%20of%20Young%20Adults%20with%20Acute_WOS.pdf
first_indexed	2023-09-18T21:44:11Z
last_indexed	2023-09-18T21:44:11Z
_version_	1777413339524104192

Proteomic profiles of young adults with acute myocardial infarction

Similar Items