Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats

Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley...

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Main Authors:	Al-Ani, Imad M Al-Ani, Ku Zaifah, Norsidah, AlJoufi, Fakhria A. AlJoufi, Mokhtar, Rafidah H.Mokhtar, A. Talib, Norlelawati A. Talib, Faisa, Ghasak Ghazi Faisa
Format:	Article
Language:	English English
Published:	Pharmacognosy Journal 2019
Subjects:	RG Gynecology and obstetrics RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/73400/ http://irep.iium.edu.my/73400/ http://irep.iium.edu.my/73400/ http://irep.iium.edu.my/73400/1/Paper%20Fakhria%202019.pdf http://irep.iium.edu.my/73400/7/73400_Protective%20role%20of%20eurycoma%20longifolia%20jack%20root%20extract%20against%20high-fat%20diet%20induced%20testicular%20damage%20in%20sprague-dawley%20rats_Scopus.pdf

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spelling	iium-734002020-01-09T08:27:48Z http://irep.iium.edu.my/73400/ Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats Al-Ani, Imad M Al-Ani Ku Zaifah, Norsidah AlJoufi, Fakhria A. AlJoufi Mokhtar, Rafidah H.Mokhtar A. Talib, Norlelawati A. Talib Faisa, Ghasak Ghazi Faisa RG Gynecology and obstetrics RM Therapeutics. Pharmacology Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal’s testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet. Pharmacognosy Journal 2019-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73400/1/Paper%20Fakhria%202019.pdf application/pdf en http://irep.iium.edu.my/73400/7/73400_Protective%20role%20of%20eurycoma%20longifolia%20jack%20root%20extract%20against%20high-fat%20diet%20induced%20testicular%20damage%20in%20sprague-dawley%20rats_Scopus.pdf Al-Ani, Imad M Al-Ani and Ku Zaifah, Norsidah and AlJoufi, Fakhria A. AlJoufi and Mokhtar, Rafidah H.Mokhtar and A. Talib, Norlelawati A. Talib and Faisa, Ghasak Ghazi Faisa (2019) Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats. Pharmacognosy Journal, 11 (4 (July-August)). pp. 808-811. ISSN 0975-3575 https://www.phcogj.com/article/914 10.5530/pj.2019.11.129
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics RM Therapeutics. Pharmacology
spellingShingle	RG Gynecology and obstetrics RM Therapeutics. Pharmacology Al-Ani, Imad M Al-Ani Ku Zaifah, Norsidah AlJoufi, Fakhria A. AlJoufi Mokhtar, Rafidah H.Mokhtar A. Talib, Norlelawati A. Talib Faisa, Ghasak Ghazi Faisa Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
description	Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal’s testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.
format	Article
author	Al-Ani, Imad M Al-Ani Ku Zaifah, Norsidah AlJoufi, Fakhria A. AlJoufi Mokhtar, Rafidah H.Mokhtar A. Talib, Norlelawati A. Talib Faisa, Ghasak Ghazi Faisa
author_facet	Al-Ani, Imad M Al-Ani Ku Zaifah, Norsidah AlJoufi, Fakhria A. AlJoufi Mokhtar, Rafidah H.Mokhtar A. Talib, Norlelawati A. Talib Faisa, Ghasak Ghazi Faisa
author_sort	Al-Ani, Imad M Al-Ani
title	Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
title_short	Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
title_full	Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
title_fullStr	Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
title_full_unstemmed	Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
title_sort	protective role of eurycoma longifolia jack root extract against high-fat diet induced testicular damage in sprague-dawley rats
publisher	Pharmacognosy Journal
publishDate	2019
url	http://irep.iium.edu.my/73400/ http://irep.iium.edu.my/73400/ http://irep.iium.edu.my/73400/ http://irep.iium.edu.my/73400/1/Paper%20Fakhria%202019.pdf http://irep.iium.edu.my/73400/7/73400_Protective%20role%20of%20eurycoma%20longifolia%20jack%20root%20extract%20against%20high-fat%20diet%20induced%20testicular%20damage%20in%20sprague-dawley%20rats_Scopus.pdf
first_indexed	2023-09-18T21:44:04Z
last_indexed	2023-09-18T21:44:04Z
_version_	1777413331958628352

Protective role of Eurycoma Longifolia Jack root extract against high-fat diet induced testicular damage in sprague-dawley rats

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