Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC50 = 38.68 ± 4.42 µM). The most potent...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
MDPI
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/72692/ http://irep.iium.edu.my/72692/ http://irep.iium.edu.my/72692/ http://irep.iium.edu.my/72692/1/72692%20Synthesis%20of%20Thymidine%20Phosphorylase.pdf http://irep.iium.edu.my/72692/2/72692%20Synthesis%20of%20Thymidine%20Phosphorylase%20SCOPUS.pdf http://irep.iium.edu.my/72692/13/72692_Synthesis%20of%20Thymidine%20Phosphorylase%20Inhibitor%20Based%20on%20Quinoxaline%20Derivatives%20and%20Their%20Molecular%20Docking%20Study_wos.pdf |