Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats
Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical...
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Penerbit Universiti Sains Malaysia
2019
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iium-726092019-06-13T07:07:39Z http://irep.iium.edu.my/72609/ Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats Abdul Razak, Redzuan Nul Hakim Ismail, Faridah Md Isa, Muhammad Lokman Abdul Wahab, Azantee Yazmie Muhammad, Hussin Ramli, Roszaman Raja Ismail, Raja Arif Shah R Medicine (General) RS Pharmacy and materia medica Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate the protective effects of AM leaves extract on sperm quality following toxic exposure to CP. Methods: Forty-eight male Sprague Dawley rats were allocated into eight groups of six rats (n = 6): control, CP only (200 mg kg−1 ), AM only (100 mg kg−1 , 300 mg kg−1 and 500 mg kg−1 ) and CP + AM (100 mg kg−1 , 300 mg kg−1 and 500 mg kg−1 ). Animals were sacrificed after 63 days of treatment and the sperm from the caudal epididymis was taken for sperm analysis. Results: The body and the reproductive organs weight, sperm count and motility did not differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the dead and abnormal sperm were seen in the CP alone treated group compared to the control group. Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of abnormal sperm as compared to the CP only group. Conclusion: Overall, the present results represent the potential of AM to protect against CP induced reproductive toxicity. Penerbit Universiti Sains Malaysia 2019-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/72609/1/72609%20Ameliorative%20Effects.pdf application/pdf en http://irep.iium.edu.my/72609/2/72609%20Ameliorative%20effects%20of%20Aquilaria%20SCOPUS.pdf Abdul Razak, Redzuan Nul Hakim and Ismail, Faridah and Md Isa, Muhammad Lokman and Abdul Wahab, Azantee Yazmie and Muhammad, Hussin and Ramli, Roszaman and Raja Ismail, Raja Arif Shah (2019) Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats. Malaysian Journal of Medical Sciences, 26 (1). pp. 44-57. ISSN 1394-195X E-ISSN 2180-4303 http://www.mjms.usm.my/MJMS26012019/04MJMS26012019_OA1.pdf 10.21315/mjms2019.26.1.4 |
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Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
R Medicine (General) RS Pharmacy and materia medica |
| spellingShingle |
R Medicine (General) RS Pharmacy and materia medica Abdul Razak, Redzuan Nul Hakim Ismail, Faridah Md Isa, Muhammad Lokman Abdul Wahab, Azantee Yazmie Muhammad, Hussin Ramli, Roszaman Raja Ismail, Raja Arif Shah Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| description |
Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and
immunosuppressive agent that is associated with adverse side effects including reproductive
toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit
high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate
the protective effects of AM leaves extract on sperm quality following toxic exposure to CP.
Methods: Forty-eight male Sprague Dawley rats were allocated into eight groups of six
rats (n = 6): control, CP only (200 mg kg−1
), AM only (100 mg kg−1
, 300 mg kg−1
and 500 mg kg−1
)
and CP + AM (100 mg kg−1
, 300 mg kg−1
and 500 mg kg−1
). Animals were sacrificed after 63 days of
treatment and the sperm from the caudal epididymis was taken for sperm analysis.
Results: The body and the reproductive organs weight, sperm count and motility did not
differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the
dead and abnormal sperm were seen in the CP alone treated group compared to the control group.
Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of
abnormal sperm as compared to the CP only group.
Conclusion: Overall, the present results represent the potential of AM to protect against
CP induced reproductive toxicity. |
| format |
Article |
| author |
Abdul Razak, Redzuan Nul Hakim Ismail, Faridah Md Isa, Muhammad Lokman Abdul Wahab, Azantee Yazmie Muhammad, Hussin Ramli, Roszaman Raja Ismail, Raja Arif Shah |
| author_facet |
Abdul Razak, Redzuan Nul Hakim Ismail, Faridah Md Isa, Muhammad Lokman Abdul Wahab, Azantee Yazmie Muhammad, Hussin Ramli, Roszaman Raja Ismail, Raja Arif Shah |
| author_sort |
Abdul Razak, Redzuan Nul Hakim |
| title |
Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| title_short |
Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| title_full |
Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| title_fullStr |
Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| title_full_unstemmed |
Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| title_sort |
ameliorative effects of aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats |
| publisher |
Penerbit Universiti Sains Malaysia |
| publishDate |
2019 |
| url |
http://irep.iium.edu.my/72609/ http://irep.iium.edu.my/72609/ http://irep.iium.edu.my/72609/ http://irep.iium.edu.my/72609/1/72609%20Ameliorative%20Effects.pdf http://irep.iium.edu.my/72609/2/72609%20Ameliorative%20effects%20of%20Aquilaria%20SCOPUS.pdf |
| first_indexed |
2023-09-18T21:42:52Z |
| last_indexed |
2023-09-18T21:42:52Z |
| _version_ |
1777413257014804480 |