Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
Plants constitute a major ingredient in traditional or folk medicine. The therapeutic claims made on the use of these traditional medicinal plants range from simple conditions such as fevers and migraines, to more complex diseases such as cancer, metabolic syndrome and diabetes mellitus. The aque...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Universiti Putra Malaysia (UPM)
2019
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/71835/ http://irep.iium.edu.my/71835/ http://irep.iium.edu.my/71835/1/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_article.pdf http://irep.iium.edu.my/71835/2/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_wos.pdf http://irep.iium.edu.my/71835/13/71835_Evaluation%20of%20the%20%CE%B1-glucosidase%20inhibitory_scopus.pdf |
| Summary: | Plants constitute a major ingredient in traditional or folk medicine. The therapeutic claims
made on the use of these traditional medicinal plants range from simple conditions such as
fevers and migraines, to more complex diseases such as cancer, metabolic syndrome and
diabetes mellitus. The aqueous ethanolic extracts of five medicinal plant species; Cosmos
caudatus, Leucaena leucocephala, Momordica charantia, Pereskia bleo and Averrhoa bilimbi
were assessed for glucose lowering effect via the in vitro α-glucosidase inhibition assay. Their
antioxidant potential, represented by their DPPH radical scavenging activity and total phenolic
contents were also measured. The most potent α-glucosidase inhibitory activity was recorded
for the leaf extract of C. caudatus with IC50 of 21.90 ± 3.60 µg/mL, followed by L. leucocephala
with IC50 value of 30.80 ± 2.50 µg/mL. Momordica charantia, P. bleo and A. bilimbi did not
show any significant inhibition of α-glucosidase. Meanwhile C. caudatus also gave the highest
DPPH radical scavenging activity with IC50 value of 272.46 ± 8.98 µg/mL, and the highest
total phenolic content with a value of 0.263 ± 0.02 g GAE/g DW. The present work provides
a priority list of interesting plants for further study with respect to the treatment of diabetes. |
|---|