Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines

Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines

Chondroitin Sulfate (CS) is the main constituent of Blue-spotted Stingray which shows promising in vitro anticancer activities in cancer cell lines. However, the effects of CS on human breast cancer and cervical cancer cell lines remain to be explored. Here we report that CS induced different degree...

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Main Authors: Mazlan, Mazma Syahidatul Ayuni, Ichwan, Solachuddin J. A., Rosli, Norhayati
Format: Article
Language:English
English
Published: Ektodermal Displazi Grubu 2019
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/71833/
http://irep.iium.edu.my/71833/
http://irep.iium.edu.my/71833/1/71833_Effects%20of%20Chondroitin%20Sulfate%20%28CS%29%20on%20%28HeLa%29.pdf
http://irep.iium.edu.my/71833/7/71833_Effects%20of%20Chondroitin%20Sulfate_Scopus.pdf
id iium-71833
recordtype eprints
spelling iium-718332019-11-24T15:46:46Z http://irep.iium.edu.my/71833/ Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines Mazlan, Mazma Syahidatul Ayuni Ichwan, Solachuddin J. A. Rosli, Norhayati RM Therapeutics. Pharmacology Chondroitin Sulfate (CS) is the main constituent of Blue-spotted Stingray which shows promising in vitro anticancer activities in cancer cell lines. However, the effects of CS on human breast cancer and cervical cancer cell lines remain to be explored. Here we report that CS induced different degree of cytotoxicity in two human cancer cell lines, cervical cancer HeLa and breast cancer MCF-7 cell lines. We found that MCF-7 was more resistant to CS exposure than HeLa cell line. Moreover, CS induced apoptosis in HeLa but not MCF-7 cell line as shown by caspase-3 activity assay. The CS-induced caspase-3 activation in HeLa cells was also confirmed by using quantititative RT-PCR. Our findings show that the caspase-3 activation induced by CS in HeLa cells was transcriptional. These results indicate that as an anticancer candidate, CS is more potent on cervical cancer than the breast cancer cell line. Ektodermal Displazi Grubu 2019-04-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71833/1/71833_Effects%20of%20Chondroitin%20Sulfate%20%28CS%29%20on%20%28HeLa%29.pdf application/pdf en http://irep.iium.edu.my/71833/7/71833_Effects%20of%20Chondroitin%20Sulfate_Scopus.pdf Mazlan, Mazma Syahidatul Ayuni and Ichwan, Solachuddin J. A. and Rosli, Norhayati (2019) Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines. Journal of International Dental and Medical Research, 12 (1). pp. 38-41. ISSN 1309-100X http://www.jidmr.com/journal/wp-content/uploads/2019/04/7-D18_726_Solachuddin_J_A_Ichwan.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Mazlan, Mazma Syahidatul Ayuni
Ichwan, Solachuddin J. A.
Rosli, Norhayati
Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines
description Chondroitin Sulfate (CS) is the main constituent of Blue-spotted Stingray which shows promising in vitro anticancer activities in cancer cell lines. However, the effects of CS on human breast cancer and cervical cancer cell lines remain to be explored. Here we report that CS induced different degree of cytotoxicity in two human cancer cell lines, cervical cancer HeLa and breast cancer MCF-7 cell lines. We found that MCF-7 was more resistant to CS exposure than HeLa cell line. Moreover, CS induced apoptosis in HeLa but not MCF-7 cell line as shown by caspase-3 activity assay. The CS-induced caspase-3 activation in HeLa cells was also confirmed by using quantititative RT-PCR. Our findings show that the caspase-3 activation induced by CS in HeLa cells was transcriptional. These results indicate that as an anticancer candidate, CS is more potent on cervical cancer than the breast cancer cell line.
format Article
author Mazlan, Mazma Syahidatul Ayuni
Ichwan, Solachuddin J. A.
Rosli, Norhayati
author_facet Mazlan, Mazma Syahidatul Ayuni
Ichwan, Solachuddin J. A.
Rosli, Norhayati
author_sort Mazlan, Mazma Syahidatul Ayuni
title Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines
title_short Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines
title_full Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines
title_fullStr Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines
title_full_unstemmed Effects of Chondroitin Sulfate (CS) on (HeLa) Cervical Cancer and Breast Cancer (MCF-7) cell lines
title_sort effects of chondroitin sulfate (cs) on (hela) cervical cancer and breast cancer (mcf-7) cell lines
publisher Ektodermal Displazi Grubu
publishDate 2019
url http://irep.iium.edu.my/71833/
http://irep.iium.edu.my/71833/
http://irep.iium.edu.my/71833/1/71833_Effects%20of%20Chondroitin%20Sulfate%20%28CS%29%20on%20%28HeLa%29.pdf
http://irep.iium.edu.my/71833/7/71833_Effects%20of%20Chondroitin%20Sulfate_Scopus.pdf
first_indexed 2023-09-18T21:41:50Z
last_indexed 2023-09-18T21:41:50Z
_version_ 1777413192166670336

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