Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated f...

Full description

Bibliographic Details
Main Authors:	Shieh Ting, Kan, Ahmad, Mohamad Syahrizal, Syed Abdul Azziz, Saripah Salbiah, Awang, Khalijah, Mhd Bakri, Yuhanis, Nafiah, Mohd Azlan, Abbas, Phirdaous, Hashim, Yumi Zuhanis Has-Yun
Format:	Article
Language:	English English
Published:	Marmara University Press 2019
Subjects:	QR180 Immunology RC Internal medicine RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/71573/ http://irep.iium.edu.my/71573/ http://irep.iium.edu.my/71573/ http://irep.iium.edu.my/71573/1/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_article.pdf http://irep.iium.edu.my/71573/2/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_wos.pdf

id	iium-71573
recordtype	eprints
spelling	iium-715732019-07-12T03:24:17Z http://irep.iium.edu.my/71573/ Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line Shieh Ting, Kan Ahmad, Mohamad Syahrizal Syed Abdul Azziz, Saripah Salbiah Awang, Khalijah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun QR180 Immunology RC Internal medicine RM Therapeutics. Pharmacology Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data (1H, 13C and LCMS) and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra. Marmara University Press 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71573/1/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_article.pdf application/pdf en http://irep.iium.edu.my/71573/2/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_wos.pdf Shieh Ting, Kan and Ahmad, Mohamad Syahrizal and Syed Abdul Azziz, Saripah Salbiah and Awang, Khalijah and Mhd Bakri, Yuhanis and Nafiah, Mohd Azlan and Abbas, Phirdaous and Hashim, Yumi Zuhanis Has-Yun (2019) Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line. Journal of Research in Pharmacy, 23 (2). pp. 217-223. ISSN 2630-6344 http://jrespharm.com/uploads/pdf/pdf_MPJ_649.pdf 10.12991/jrp.2019.127
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QR180 Immunology RC Internal medicine RM Therapeutics. Pharmacology
spellingShingle	QR180 Immunology RC Internal medicine RM Therapeutics. Pharmacology Shieh Ting, Kan Ahmad, Mohamad Syahrizal Syed Abdul Azziz, Saripah Salbiah Awang, Khalijah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
description	Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data (1H, 13C and LCMS) and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.
format	Article
author	Shieh Ting, Kan Ahmad, Mohamad Syahrizal Syed Abdul Azziz, Saripah Salbiah Awang, Khalijah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun
author_facet	Shieh Ting, Kan Ahmad, Mohamad Syahrizal Syed Abdul Azziz, Saripah Salbiah Awang, Khalijah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun
author_sort	Shieh Ting, Kan
title	Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
title_short	Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
title_full	Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
title_fullStr	Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
title_full_unstemmed	Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
title_sort	oxoaporphine alkaloids from the barks of platymitra siamensis craib (annonaceae) and their cytotoxicity against mcf-7 cancer cell line
publisher	Marmara University Press
publishDate	2019
url	http://irep.iium.edu.my/71573/ http://irep.iium.edu.my/71573/ http://irep.iium.edu.my/71573/ http://irep.iium.edu.my/71573/1/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_article.pdf http://irep.iium.edu.my/71573/2/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_wos.pdf
first_indexed	2023-09-18T21:41:28Z
last_indexed	2023-09-18T21:41:28Z
_version_	1777413168655499264

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Similar Items