Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy

Purpose: This study evaluated the risk of opioid dose escalation as it relates to sex differences among patients receiving opioids for long-term therapy. Patients and methods: This retrospective cohort study was conducted in tertiary hospital settings in Malaysia using electronic prescription rec...

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Main Authors:	Zin, Che Suraya, Alias, Nor Elina, Mohd Taufek, Nor Hidayah, Meor Ahmad, Mazlila
Format:	Article
Language:	English English English English
Published:	Dove Press Ltd. 2019
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/1/190309_Manuscript.pdf http://irep.iium.edu.my/71531/2/190409_acceptance.JPG http://irep.iium.edu.my/71531/12/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation%20among%20Malaysian%20patients%20with%20long%20term%20opioid%20therapy.pdf http://irep.iium.edu.my/71531/19/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation%20among%20Malaysian%20patients%20with%20long%20term%20opioid%20therapy_Scopus.pdf

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spelling	iium-715312020-02-06T07:02:57Z http://irep.iium.edu.my/71531/ Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila RM Therapeutics. Pharmacology Purpose: This study evaluated the risk of opioid dose escalation as it relates to sex differences among patients receiving opioids for long-term therapy. Patients and methods: This retrospective cohort study was conducted in tertiary hospital settings in Malaysia using electronic prescription records. Opioid naïve patients, aged ≥ 18 years, who were undergoing long-term opioid therapy of ≥ 90 days, with at least one opioid prescription (buprenorphine, morphine, oxycodone, fentanyl, dihydrocodeine or tramadol) between 1st January 2011 and 31st December 2016, were included in the study. They were followed until (i) the end of the study period, (ii) death from any cause or (iii) discontinuation of therapy from their first opioid prescription without any intervals of ≥ 120 days between successive prescriptions. The risk of high opioid dose escalation to ≥ 100 mg/day and ≥ 200 mg/day relative to men and women was measured. Results: A total of 4688 patients (58.8% women, 41.3% men) on long-term opioid therapy were identified. Among these patients, 248 (5.29%) were escalated to high opioid doses of ≥ 100 mg/day and 69 (1.47%) were escalated to ≥ 200 mg/day. The escalation to high-dose opioid therapy was more likely to occur in men than in women, even after adjustment for age (dose ≥ 100 mg/day [adjusted hazard ratio 2.32; 95% confidence interval (CI), 1.79 to 3.00; p < 0.0001] and ≥ 200 mg/day [adjusted hazard ratio 6.10; 95% CI, 3.39 to 10.98; p < 0.0001]). Conclusion: The risk of opioid dose escalation differed between men and women, as men were at higher risk than women for high opioid dose escalation. Dove Press Ltd. 2019-03-26 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71531/1/190309_Manuscript.pdf application/pdf en http://irep.iium.edu.my/71531/2/190409_acceptance.JPG application/pdf en http://irep.iium.edu.my/71531/12/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation%20among%20Malaysian%20patients%20with%20long%20term%20opioid%20therapy.pdf application/pdf en http://irep.iium.edu.my/71531/19/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation%20among%20Malaysian%20patients%20with%20long%20term%20opioid%20therapy_Scopus.pdf Zin, Che Suraya and Alias, Nor Elina and Mohd Taufek, Nor Hidayah and Meor Ahmad, Mazlila (2019) Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy. Journal of Pain Research. pp. 1-21. ISSN 1178-7090 (In Press) https://www.dovepress.com/journal-of-pain-research-journal
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
description	Purpose: This study evaluated the risk of opioid dose escalation as it relates to sex differences among patients receiving opioids for long-term therapy. Patients and methods: This retrospective cohort study was conducted in tertiary hospital settings in Malaysia using electronic prescription records. Opioid naïve patients, aged ≥ 18 years, who were undergoing long-term opioid therapy of ≥ 90 days, with at least one opioid prescription (buprenorphine, morphine, oxycodone, fentanyl, dihydrocodeine or tramadol) between 1st January 2011 and 31st December 2016, were included in the study. They were followed until (i) the end of the study period, (ii) death from any cause or (iii) discontinuation of therapy from their first opioid prescription without any intervals of ≥ 120 days between successive prescriptions. The risk of high opioid dose escalation to ≥ 100 mg/day and ≥ 200 mg/day relative to men and women was measured. Results: A total of 4688 patients (58.8% women, 41.3% men) on long-term opioid therapy were identified. Among these patients, 248 (5.29%) were escalated to high opioid doses of ≥ 100 mg/day and 69 (1.47%) were escalated to ≥ 200 mg/day. The escalation to high-dose opioid therapy was more likely to occur in men than in women, even after adjustment for age (dose ≥ 100 mg/day [adjusted hazard ratio 2.32; 95% confidence interval (CI), 1.79 to 3.00; p < 0.0001] and ≥ 200 mg/day [adjusted hazard ratio 6.10; 95% CI, 3.39 to 10.98; p < 0.0001]). Conclusion: The risk of opioid dose escalation differed between men and women, as men were at higher risk than women for high opioid dose escalation.
format	Article
author	Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila
author_facet	Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila
author_sort	Zin, Che Suraya
title	Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
title_short	Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
title_full	Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
title_fullStr	Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
title_full_unstemmed	Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
title_sort	sex differences in high opioid dose escalation among malaysian patients with long term opioid therapy
publisher	Dove Press Ltd.
publishDate	2019
url	http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/1/190309_Manuscript.pdf http://irep.iium.edu.my/71531/2/190409_acceptance.JPG http://irep.iium.edu.my/71531/12/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation%20among%20Malaysian%20patients%20with%20long%20term%20opioid%20therapy.pdf http://irep.iium.edu.my/71531/19/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation%20among%20Malaysian%20patients%20with%20long%20term%20opioid%20therapy_Scopus.pdf
first_indexed	2023-09-18T21:41:26Z
last_indexed	2023-09-18T21:41:26Z
_version_	1777413166005747712

Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy

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