The effect of flaxseed extract on skin elasticity of the healing wound in rabbit

Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications...

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Main Authors:	Abdul Qader, Omar Abdul Jabbar, Mustafa Al-Ahmad, Basma Ezzat, Kashmola, Muhanad Ali Hamdon, Mokhtar@Makhtar, Khairani Idah, Muhammad, Siti Aesah @ Naznin, Abdul Rahim, Roslina
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Sultan Zainal Abidin 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/71481/ http://irep.iium.edu.my/71481/ http://irep.iium.edu.my/71481/1/71481_The%20Effect%20of%20Flaxseed%20Extract%20on%20Skin.pdf

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recordtype	eprints
spelling	iium-714812019-04-04T08:32:56Z http://irep.iium.edu.my/71481/ The effect of flaxseed extract on skin elasticity of the healing wound in rabbit Abdul Qader, Omar Abdul Jabbar Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Muhammad, Siti Aesah @ Naznin Abdul Rahim, Roslina R Medicine (General) Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid formations, a poor final cosmetic appearance and the formation of a fragile epithelial layer. The objective of this study is to evaluate the effectiveness of flaxseed gel in enhancing connective tissue firmness and improving skin texture during wound healing by means of viscoelasticity parameter. 30-male white neozealand rabbit were included in this study divided into 3 groups; one group of 10 rabbit received Flax seed gel topically for three times intervals (1, 3, and 7 days); a second group received Fucidin cream as positive control, while third group have not received any treatment as negative control, Skin elasticity measurements were performed using the DermaLab system (Cortex Technology). Photos of treated areas were taken during the procedure. Throughout the study skin elasticity was significantly greater in the Flaxseed group than in other groups. Flaxseed increase elasticity value from (4.2±1.02) to (4.7±1.9) after 7 days treatment (P=0.003). while no significant differences were evident in both Fucidin treated group (positive) control (1.0±0.34) and non-treated group (negative) control (1.8±1.4) (p=0.068) group. Hence, Young's modulus of skin elasticity in flaxseed group was more reproducible than other groups demonstrating the comparable efficacy of flaxseed extract in skin elasticity and distensibility. This study showed clearly the therapeutic effect of flaxseed extract on biologic tissue, including stimulation of microcirculation and improvement of fibroblastic cell activity. Elasticity evaluation demonstrated increased density and firmness in the network of collagen/elastic fibers in the dermis and subcutis during wound healing process promise in generating therapeutic gel to be used in wound healing process. Faculty of Medicine, Universiti Sultan Zainal Abidin 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71481/1/71481_The%20Effect%20of%20Flaxseed%20Extract%20on%20Skin.pdf Abdul Qader, Omar Abdul Jabbar and Mustafa Al-Ahmad, Basma Ezzat and Kashmola, Muhanad Ali Hamdon and Mokhtar@Makhtar, Khairani Idah and Muhammad, Siti Aesah @ Naznin and Abdul Rahim, Roslina (2018) The effect of flaxseed extract on skin elasticity of the healing wound in rabbit. Asian Journal of Medicine and Biomedicine, Supplementary 3. p. 109. ISSN 0127-9319 E-ISSN 2600-8173 https://journal.unisza.edu.my/ajmb/index.php/ajmb/article/view/161/109
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdul Qader, Omar Abdul Jabbar Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Muhammad, Siti Aesah @ Naznin Abdul Rahim, Roslina The effect of flaxseed extract on skin elasticity of the healing wound in rabbit
description	Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in such wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable complications including keloid formations, a poor final cosmetic appearance and the formation of a fragile epithelial layer. The objective of this study is to evaluate the effectiveness of flaxseed gel in enhancing connective tissue firmness and improving skin texture during wound healing by means of viscoelasticity parameter. 30-male white neozealand rabbit were included in this study divided into 3 groups; one group of 10 rabbit received Flax seed gel topically for three times intervals (1, 3, and 7 days); a second group received Fucidin cream as positive control, while third group have not received any treatment as negative control, Skin elasticity measurements were performed using the DermaLab system (Cortex Technology). Photos of treated areas were taken during the procedure. Throughout the study skin elasticity was significantly greater in the Flaxseed group than in other groups. Flaxseed increase elasticity value from (4.2±1.02) to (4.7±1.9) after 7 days treatment (P=0.003). while no significant differences were evident in both Fucidin treated group (positive) control (1.0±0.34) and non-treated group (negative) control (1.8±1.4) (p=0.068) group. Hence, Young's modulus of skin elasticity in flaxseed group was more reproducible than other groups demonstrating the comparable efficacy of flaxseed extract in skin elasticity and distensibility. This study showed clearly the therapeutic effect of flaxseed extract on biologic tissue, including stimulation of microcirculation and improvement of fibroblastic cell activity. Elasticity evaluation demonstrated increased density and firmness in the network of collagen/elastic fibers in the dermis and subcutis during wound healing process promise in generating therapeutic gel to be used in wound healing process.
format	Article
author	Abdul Qader, Omar Abdul Jabbar Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Muhammad, Siti Aesah @ Naznin Abdul Rahim, Roslina
author_facet	Abdul Qader, Omar Abdul Jabbar Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Muhammad, Siti Aesah @ Naznin Abdul Rahim, Roslina
author_sort	Abdul Qader, Omar Abdul Jabbar
title	The effect of flaxseed extract on skin elasticity of the healing wound in rabbit
title_short	The effect of flaxseed extract on skin elasticity of the healing wound in rabbit
title_full	The effect of flaxseed extract on skin elasticity of the healing wound in rabbit
title_fullStr	The effect of flaxseed extract on skin elasticity of the healing wound in rabbit
title_full_unstemmed	The effect of flaxseed extract on skin elasticity of the healing wound in rabbit
title_sort	effect of flaxseed extract on skin elasticity of the healing wound in rabbit
publisher	Faculty of Medicine, Universiti Sultan Zainal Abidin
publishDate	2018
url	http://irep.iium.edu.my/71481/ http://irep.iium.edu.my/71481/ http://irep.iium.edu.my/71481/1/71481_The%20Effect%20of%20Flaxseed%20Extract%20on%20Skin.pdf
first_indexed	2023-09-18T21:41:21Z
last_indexed	2023-09-18T21:41:21Z
_version_	1777413161674080256

The effect of flaxseed extract on skin elasticity of the healing wound in rabbit

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