The effect of flaxseed extract on skin elasticity of the healing wound in rabbits
Introduction: Management of disturbed wounds, large skin defects and the areas where skin tension precludes wound closure is of high clinical importance. Healing in wounds occurs through epithelization and contraction processes (second-intentions healing) that may result in certain undesirable com...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Kulliyyah of Medicine, International Islamic University Malaysia
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/71466/ http://irep.iium.edu.my/71466/ http://irep.iium.edu.my/71466/1/71466_The%20Effect%20of%20Flaxseed%20Extract%20on%20Skin.pdf http://irep.iium.edu.my/71466/7/71466_The%20effect%20of%20flaxseed%20extract%20on%20skin%20elasticity%20_scopus.pdf http://irep.iium.edu.my/71466/13/71466_The%20Effect%20of%20Flaxseed%20Extract%20on%20Skin%20Elasticity%20of%20The%20Healing%20Wound%20In%20Rabbits_wos.pdf |
| Summary: | Introduction: Management of disturbed wounds, large skin defects and the areas where skin tension
precludes wound closure is of high clinical importance. Healing in wounds occurs through epithelization and
contraction processes (second-intentions healing) that may result in certain undesirable complications
including keloid and formation of a fragile epithelial layer. Materials and methods: 27 white New Zealand
rabbit included in this study divided into 3 groups; one group of 9 rabbits received Flaxseed gel topically for
three time intervals (1, 7, and 14 days); a second group received Fucidin cream as positive control, while a
third group has not received any treatment as negative control, Skin elasticity measurements were
performed using the DermaLab system. Results: Throughout the study, skin elasticity was significantly
greater in Flaxseed group than in others. Flaxseed decrease elasticity value from (3.46 ± 2.05). Hence,
Young's modulus of skin elasticity in flaxseed group was (2.46 ± 1.02) after 14 days (p = 0.003), while no
significant differences were evident in both Fucidin group (1.16 ± 0.77) and non-treated group (1.86 ± 1.40)
(p = 0.019), accordingly flaxseed extract more reproducible than other groups demonstrating comparable
efficacy in skin elasticity and distensibility. Conclusions: This study showed the therapeutic effect of
flaxseed on biologic tissue. Elasticity evaluation demonstrated increased density and firmness in the network
of collagen fibers in the dermis and subcutis during wound healing process promise in generating therapeutic
gel to be used in wound healing process. |
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