Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation,antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500 mg/kg body weight) were a...

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Main Authors:	M Jaffri, Juliana, Mohamed, Suhaila, Ahmad, Intan Natasya, M. Mustapha, Noordin, A. manap, Yazid, Rohimi, Nordanial
Format:	Article
Language:	English
Published:	Elsevier 2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/7074/ http://irep.iium.edu.my/7074/ http://irep.iium.edu.my/7074/ http://irep.iium.edu.my/7074/1/Liver_%26_kidney_paper.pdf

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spelling	iium-70742011-12-23T07:46:01Z http://irep.iium.edu.my/7074/ Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver M Jaffri, Juliana Mohamed, Suhaila Ahmad, Intan Natasya M. Mustapha, Noordin A. manap, Yazid Rohimi, Nordanial RS Pharmacy and materia medica Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation,antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500 mg/kg body weight) were administered orally to normal Wistar Kyoto rats, spontaneously hypertensive rats (SHR) and N-x-nitro-L-arginine methyl ester (L-NAME)-induced NO-deficient hypertensive rats. The OPLE reduced hypertension in NO-deficient rats, but not in SHR. Hepatocytes or glomeruli injury and oxidative markers were high in hypertensive rats compared to normal rats, and they were reduced (p < 0.05) by OPLE supplementation, even when there was no blood pressure reduction. Unlike the hypertensive drug captopril,the OPLE showed no toxicity to normal rats. The dose reported is equivalent 0.5 g of catechins/ day for humans or 2.5 cups of tea. The catechins are from an abundant alternative source for potential use as functional food. Elsevier 2011-03-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/7074/1/Liver_%26_kidney_paper.pdf M Jaffri, Juliana and Mohamed, Suhaila and Ahmad, Intan Natasya and M. Mustapha, Noordin and A. manap, Yazid and Rohimi, Nordanial (2011) Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver. Food Chemistry, 128 (2). pp. 433-441. ISSN 0308-8146 http://www.journals.elsevier.com/food-chemistry/ DOIi:10.1016/j.foodchem.2011.03.050
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica M Jaffri, Juliana Mohamed, Suhaila Ahmad, Intan Natasya M. Mustapha, Noordin A. manap, Yazid Rohimi, Nordanial Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
description	Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation,antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500 mg/kg body weight) were administered orally to normal Wistar Kyoto rats, spontaneously hypertensive rats (SHR) and N-x-nitro-L-arginine methyl ester (L-NAME)-induced NO-deficient hypertensive rats. The OPLE reduced hypertension in NO-deficient rats, but not in SHR. Hepatocytes or glomeruli injury and oxidative markers were high in hypertensive rats compared to normal rats, and they were reduced (p < 0.05) by OPLE supplementation, even when there was no blood pressure reduction. Unlike the hypertensive drug captopril,the OPLE showed no toxicity to normal rats. The dose reported is equivalent 0.5 g of catechins/ day for humans or 2.5 cups of tea. The catechins are from an abundant alternative source for potential use as functional food.
format	Article
author	M Jaffri, Juliana Mohamed, Suhaila Ahmad, Intan Natasya M. Mustapha, Noordin A. manap, Yazid Rohimi, Nordanial
author_facet	M Jaffri, Juliana Mohamed, Suhaila Ahmad, Intan Natasya M. Mustapha, Noordin A. manap, Yazid Rohimi, Nordanial
author_sort	M Jaffri, Juliana
title	Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
title_short	Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
title_full	Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
title_fullStr	Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
title_full_unstemmed	Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
title_sort	effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver
publisher	Elsevier
publishDate	2011
url	http://irep.iium.edu.my/7074/ http://irep.iium.edu.my/7074/ http://irep.iium.edu.my/7074/ http://irep.iium.edu.my/7074/1/Liver_%26_kidney_paper.pdf
first_indexed	2023-09-18T20:16:20Z
last_indexed	2023-09-18T20:16:20Z
_version_	1777407812158095360

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

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