Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization

Interdigitated Electrodes (IDEs) have been widely used in biological cellular characterization such as the Electrical Cell-Substrate Impedance Sensing (ECIS). Optimization of IDEs are crucial to obtain high accuracy of measurement that associates with the biological cell activities. However, no...

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Main Authors:	Mohd Mansor, Ahmad Fairuzabadi, Nordin, Anis Nurashikin
Format:	Conference or Workshop Item
Language:	English English
Published:	Institute of Electrical and Electronics Engineers Inc. 2018
Subjects:	TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices
Online Access:	http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/9/70628_Theoretical%20modelling%20of%20interdigitated%20electrode.pdf http://irep.iium.edu.my/70628/2/70628_Theoretical%20modelling%20of%20interdigitated_SCOPUS.pdf

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recordtype	eprints
spelling	iium-706282019-02-28T07:01:13Z http://irep.iium.edu.my/70628/ Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization Mohd Mansor, Ahmad Fairuzabadi Nordin, Anis Nurashikin TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices Interdigitated Electrodes (IDEs) have been widely used in biological cellular characterization such as the Electrical Cell-Substrate Impedance Sensing (ECIS). Optimization of IDEs are crucial to obtain high accuracy of measurement that associates with the biological cell activities. However, not much research studies the generation of electric field by the IDEs geometry especially in cellular application. In this work, theoretical modelling of IDEs was done by modelling the IDEs equivalent circuit consisting of 3 major components; double layer capacitance, CDL, solution capacitance, CSOL and solution resistance, RSOL. Simulation using MATLAB and COMSOL Multiphysics was done to study the effect of geometrical parameters (width of electrodes (W), spacing between electrodes (S) and total number of electrodes (N)) on the cut-off frequency (FLOW), solution resistance (RSOL) and the average electric field magnitude based on the equivalent circuit model. The simulation results show three main findings; lowest FLOW to be at the ratio of a=0.54 and N16, lowest RSOL at smaller a and higher N, and saturated electric field at N18. The results suggested that the optimal configuration of IDEs with a fixed length of electrode of 7000μm is to have the ratio of (S/W) as 0.54 and N as 18. Institute of Electrical and Electronics Engineers Inc. 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/70628/9/70628_Theoretical%20modelling%20of%20interdigitated%20electrode.pdf application/pdf en http://irep.iium.edu.my/70628/2/70628_Theoretical%20modelling%20of%20interdigitated_SCOPUS.pdf Mohd Mansor, Ahmad Fairuzabadi and Nordin, Anis Nurashikin (2018) Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization. In: 7th International Conference on Computer and Communication Engineering, ICCCE 2018, 19th-20th September 2018, Kuala Lumpur. https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8539280 10.1109/ICCCE.2018.8539280
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices
spellingShingle	TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices Mohd Mansor, Ahmad Fairuzabadi Nordin, Anis Nurashikin Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
description	Interdigitated Electrodes (IDEs) have been widely used in biological cellular characterization such as the Electrical Cell-Substrate Impedance Sensing (ECIS). Optimization of IDEs are crucial to obtain high accuracy of measurement that associates with the biological cell activities. However, not much research studies the generation of electric field by the IDEs geometry especially in cellular application. In this work, theoretical modelling of IDEs was done by modelling the IDEs equivalent circuit consisting of 3 major components; double layer capacitance, CDL, solution capacitance, CSOL and solution resistance, RSOL. Simulation using MATLAB and COMSOL Multiphysics was done to study the effect of geometrical parameters (width of electrodes (W), spacing between electrodes (S) and total number of electrodes (N)) on the cut-off frequency (FLOW), solution resistance (RSOL) and the average electric field magnitude based on the equivalent circuit model. The simulation results show three main findings; lowest FLOW to be at the ratio of a=0.54 and N16, lowest RSOL at smaller a and higher N, and saturated electric field at N18. The results suggested that the optimal configuration of IDEs with a fixed length of electrode of 7000μm is to have the ratio of (S/W) as 0.54 and N as 18.
format	Conference or Workshop Item
author	Mohd Mansor, Ahmad Fairuzabadi Nordin, Anis Nurashikin
author_facet	Mohd Mansor, Ahmad Fairuzabadi Nordin, Anis Nurashikin
author_sort	Mohd Mansor, Ahmad Fairuzabadi
title	Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
title_short	Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
title_full	Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
title_fullStr	Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
title_full_unstemmed	Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
title_sort	theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
publisher	Institute of Electrical and Electronics Engineers Inc.
publishDate	2018
url	http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/9/70628_Theoretical%20modelling%20of%20interdigitated%20electrode.pdf http://irep.iium.edu.my/70628/2/70628_Theoretical%20modelling%20of%20interdigitated_SCOPUS.pdf
first_indexed	2023-09-18T21:40:16Z
last_indexed	2023-09-18T21:40:16Z
_version_	1777413092620107776

Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization

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