In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice

Garlic or Allium sativum is widely applied as alternative medicine and in ethnopharmacological studies. This study was done to evaluate the antimalarial properties of aqueous extract of garlic against Plasmodium berghei NK65. The groups of male ICR mice were intraperitoneally (i.p) infected with 0...

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Main Authors:	Ruslan, M. S., Baba, Mohd Shukri
Format:	Article
Language:	English English
Published:	Malaysian Society of Applied Biology 2018
Subjects:	RM695 Physical medicine. Physical therapy
Online Access:	http://irep.iium.edu.my/70599/ http://irep.iium.edu.my/70599/ http://irep.iium.edu.my/70599/1/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_article.pdf http://irep.iium.edu.my/70599/2/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_scopus.pdf

id	iium-70599
recordtype	eprints
spelling	iium-705992019-02-11T09:01:11Z http://irep.iium.edu.my/70599/ In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice Ruslan, M. S. Baba, Mohd Shukri RM695 Physical medicine. Physical therapy Garlic or Allium sativum is widely applied as alternative medicine and in ethnopharmacological studies. This study was done to evaluate the antimalarial properties of aqueous extract of garlic against Plasmodium berghei NK65. The groups of male ICR mice were intraperitoneally (i.p) infected with 0.1 mL of 1 × 107 parasitised red blood cells (RBC) before being orally given pre- and post-infection treatments with 0.2 mL of 100 mg/kg body weight (bw) of freeze-dried aqueous garlic extract. Parasitemia was microscopically examined and measured by Giemsa stained thin blood smear. There was a positive correlation (p<0.05, n = 6) for all assessed parameters; parasitemia density (%), survival time (day) and the ability to inhibit the parasite growth (%) between pre-treated infected mice with the other groups. However, the value recorded was still lower compared to the mice treated with commercial antimalarial drug primaquine and chloroquine. However, biochemical parameters of treated animals were in the normal range indicative of no toxicity. Histological examination showed no abnormalities and injuries on the selected vital organs. This study proved garlic has potential as alternative antimalarial drug Malaysian Society of Applied Biology 2018-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/70599/1/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_article.pdf application/pdf en http://irep.iium.edu.my/70599/2/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_scopus.pdf Ruslan, M. S. and Baba, Mohd Shukri (2018) In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice. Malaysian Applied Biology, 47 (5). pp. 17-24. ISSN 0126-8643 http://www.mabjournal.com/images/47_5_November_2018/47_05_03.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM695 Physical medicine. Physical therapy
spellingShingle	RM695 Physical medicine. Physical therapy Ruslan, M. S. Baba, Mohd Shukri In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
description	Garlic or Allium sativum is widely applied as alternative medicine and in ethnopharmacological studies. This study was done to evaluate the antimalarial properties of aqueous extract of garlic against Plasmodium berghei NK65. The groups of male ICR mice were intraperitoneally (i.p) infected with 0.1 mL of 1 × 107 parasitised red blood cells (RBC) before being orally given pre- and post-infection treatments with 0.2 mL of 100 mg/kg body weight (bw) of freeze-dried aqueous garlic extract. Parasitemia was microscopically examined and measured by Giemsa stained thin blood smear. There was a positive correlation (p<0.05, n = 6) for all assessed parameters; parasitemia density (%), survival time (day) and the ability to inhibit the parasite growth (%) between pre-treated infected mice with the other groups. However, the value recorded was still lower compared to the mice treated with commercial antimalarial drug primaquine and chloroquine. However, biochemical parameters of treated animals were in the normal range indicative of no toxicity. Histological examination showed no abnormalities and injuries on the selected vital organs. This study proved garlic has potential as alternative antimalarial drug
format	Article
author	Ruslan, M. S. Baba, Mohd Shukri
author_facet	Ruslan, M. S. Baba, Mohd Shukri
author_sort	Ruslan, M. S.
title	In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
title_short	In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
title_full	In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
title_fullStr	In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
title_full_unstemmed	In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
title_sort	in vivo antimalarial assessment and toxicity evaluation of garlic (allium sativum) in plasmodium berghei nk65-induced mice
publisher	Malaysian Society of Applied Biology
publishDate	2018
url	http://irep.iium.edu.my/70599/ http://irep.iium.edu.my/70599/ http://irep.iium.edu.my/70599/1/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_article.pdf http://irep.iium.edu.my/70599/2/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_scopus.pdf
first_indexed	2023-09-18T21:40:13Z
last_indexed	2023-09-18T21:40:13Z
_version_	1777413089416708096

In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice

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