In vivo antimalarial assessment and toxicity evaluation of garlic (Allium sativum) in plasmodium berghei NK65-induced mice
Garlic or Allium sativum is widely applied as alternative medicine and in ethnopharmacological studies. This study was done to evaluate the antimalarial properties of aqueous extract of garlic against Plasmodium berghei NK65. The groups of male ICR mice were intraperitoneally (i.p) infected with 0...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Malaysian Society of Applied Biology
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/70599/ http://irep.iium.edu.my/70599/ http://irep.iium.edu.my/70599/1/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_article.pdf http://irep.iium.edu.my/70599/2/70599_In%20vivo%20antimalarial%20assessment%20and%20toxicity_scopus.pdf |
| Summary: | Garlic or Allium sativum is widely applied as alternative medicine and in ethnopharmacological studies. This study was done
to evaluate the antimalarial properties of aqueous extract of garlic against Plasmodium berghei NK65. The groups of male
ICR mice were intraperitoneally (i.p) infected with 0.1 mL of 1 × 107 parasitised red blood cells (RBC) before being orally
given pre- and post-infection treatments with 0.2 mL of 100 mg/kg body weight (bw) of freeze-dried aqueous garlic extract.
Parasitemia was microscopically examined and measured by Giemsa stained thin blood smear. There was a positive correlation
(p<0.05, n = 6) for all assessed parameters; parasitemia density (%), survival time (day) and the ability to inhibit the parasite
growth (%) between pre-treated infected mice with the other groups. However, the value recorded was still lower compared
to the mice treated with commercial antimalarial drug primaquine and chloroquine. However, biochemical parameters of treated
animals were in the normal range indicative of no toxicity. Histological examination showed no abnormalities and injuries on
the selected vital organs. This study proved garlic has potential as alternative antimalarial drug |
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