Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells

Natural products such as agarwood oil (AO) are found to exhibit potential anticancer properties. They provide safer and better alternative to the conventional drugs used in chemotherapy treatment. However, due to the limitation of AO in terms of volatility, stability and solubility in water, a sui...

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Main Authors:	Khairudin, Nurul Hafizah, Ahmad Nor, Yusilawati, Hashim, Yumi Zuhanis Has-Yun
Format:	Conference or Workshop Item
Language:	English
Published:	Kulliyyah of Engineering, International Islamic University Malaysia 2018
Subjects:	QD Chemistry QR Microbiology
Online Access:	http://irep.iium.edu.my/70178/ http://irep.iium.edu.my/70178/7/70178%20Rough%20hollow%20mesoporous%20silica%20nanoparticles.pdf

id	iium-70178
recordtype	eprints
spelling	iium-701782019-07-15T07:15:26Z http://irep.iium.edu.my/70178/ Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells Khairudin, Nurul Hafizah Ahmad Nor, Yusilawati Hashim, Yumi Zuhanis Has-Yun QD Chemistry QR Microbiology Natural products such as agarwood oil (AO) are found to exhibit potential anticancer properties. They provide safer and better alternative to the conventional drugs used in chemotherapy treatment. However, due to the limitation of AO in terms of volatility, stability and solubility in water, a suitable carrier is needed to enhance the performance of the essential oil. Mesoporous silica nanoparticles are found to be promising carrier for AO as it is biocompatible, hydrophilic, possesses high stability, high total surface area and high pore volume properties which can reduce the limitations possessed by AO. Rough mesoporous hollow silica (RMHS) nanoparticles were used in this study as the particles known to have high loading capacity due to its pores and rough surface. By using ethanol as solvent, the ratio of AO to RMHS 20:1 with loading time of 24 hour has successfully achieved high loading efficiency as much as 62.79%. Successful loading of AO in RMHS was confirmed by Fourier transform infrared (FTIR). Sustained release of AO from RMHS has been observed, with release up to 63.8% after 72 hours. Cell viability assay (CVA) by using MTT assay showed that RMHS loaded with AO (RMHS-AO) was able to reduce the viability of MCF-7 cells up to 73% reduction after 48 hours of treatment. Kulliyyah of Engineering, International Islamic University Malaysia 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/70178/7/70178%20Rough%20hollow%20mesoporous%20silica%20nanoparticles.pdf Khairudin, Nurul Hafizah and Ahmad Nor, Yusilawati and Hashim, Yumi Zuhanis Has-Yun (2018) Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells. In: International Conference Biotechnology Engineering, ICBioE ‘18, 19-20 September, Kuala Lumpur.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry QR Microbiology
spellingShingle	QD Chemistry QR Microbiology Khairudin, Nurul Hafizah Ahmad Nor, Yusilawati Hashim, Yumi Zuhanis Has-Yun Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
description	Natural products such as agarwood oil (AO) are found to exhibit potential anticancer properties. They provide safer and better alternative to the conventional drugs used in chemotherapy treatment. However, due to the limitation of AO in terms of volatility, stability and solubility in water, a suitable carrier is needed to enhance the performance of the essential oil. Mesoporous silica nanoparticles are found to be promising carrier for AO as it is biocompatible, hydrophilic, possesses high stability, high total surface area and high pore volume properties which can reduce the limitations possessed by AO. Rough mesoporous hollow silica (RMHS) nanoparticles were used in this study as the particles known to have high loading capacity due to its pores and rough surface. By using ethanol as solvent, the ratio of AO to RMHS 20:1 with loading time of 24 hour has successfully achieved high loading efficiency as much as 62.79%. Successful loading of AO in RMHS was confirmed by Fourier transform infrared (FTIR). Sustained release of AO from RMHS has been observed, with release up to 63.8% after 72 hours. Cell viability assay (CVA) by using MTT assay showed that RMHS loaded with AO (RMHS-AO) was able to reduce the viability of MCF-7 cells up to 73% reduction after 48 hours of treatment.
format	Conference or Workshop Item
author	Khairudin, Nurul Hafizah Ahmad Nor, Yusilawati Hashim, Yumi Zuhanis Has-Yun
author_facet	Khairudin, Nurul Hafizah Ahmad Nor, Yusilawati Hashim, Yumi Zuhanis Has-Yun
author_sort	Khairudin, Nurul Hafizah
title	Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
title_short	Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
title_full	Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
title_fullStr	Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
title_full_unstemmed	Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
title_sort	rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells
publisher	Kulliyyah of Engineering, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/70178/ http://irep.iium.edu.my/70178/7/70178%20Rough%20hollow%20mesoporous%20silica%20nanoparticles.pdf
first_indexed	2023-09-18T21:39:38Z
last_indexed	2023-09-18T21:39:38Z
_version_	1777413053156950016

Rough hollow mesoporous silica nanoparticles as carrier for agarwood oil to treat cancer cells

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