Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo

Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of...

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Main Authors:	Wan Sulaiman, Wan Mohd. Azizi, Unal, Kevser
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2018
Subjects:	RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents
Online Access:	http://irep.iium.edu.my/69896/ http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf

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spelling	iium-698962019-01-24T07:39:07Z http://irep.iium.edu.my/69896/ Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of extract of Derris trifoliata on zebrafish embryo model. Materials and Methods: Zebrafihs embryos were treated with aqueous extract of Derris Trifoliata to evaluate its effects on angiogenesis and zebrafish-toxicity. Angiogenic response was analyzed using whole-mount alkaline phosphatase (AP) vessel staining on 72 hours post fertilization (hpf) zebrafish embryos. Results: 1.0 mg/ml concentration was toxic to zebrafish embryos and embryos exposed to concentrations at 0.5 mg/ml and below showed some malformations. Derris trifoliata aqueous extract also showed some anti-angiogenic activity in vivo in the zebrafish embryo model wereby at high concentration inhibited vessel formation in zebrafish embryo. Conclusions: The anti-angiogenic response of extract of Derris trifoliata in zebrafish in vivo model suggest its therapeutic potential as anti-cancer agent. 2018 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf application/pdf en http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf application/pdf en http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf application/pdf en http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf Wan Sulaiman, Wan Mohd. Azizi and Unal, Kevser (2018) Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo. In: 12th International Symposium on Pharmaceutical Sciences (ISOPS), 26 to 29th June 2018, Ankara, Turkey. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents
spellingShingle	RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
description	Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of extract of Derris trifoliata on zebrafish embryo model. Materials and Methods: Zebrafihs embryos were treated with aqueous extract of Derris Trifoliata to evaluate its effects on angiogenesis and zebrafish-toxicity. Angiogenic response was analyzed using whole-mount alkaline phosphatase (AP) vessel staining on 72 hours post fertilization (hpf) zebrafish embryos. Results: 1.0 mg/ml concentration was toxic to zebrafish embryos and embryos exposed to concentrations at 0.5 mg/ml and below showed some malformations. Derris trifoliata aqueous extract also showed some anti-angiogenic activity in vivo in the zebrafish embryo model wereby at high concentration inhibited vessel formation in zebrafish embryo. Conclusions: The anti-angiogenic response of extract of Derris trifoliata in zebrafish in vivo model suggest its therapeutic potential as anti-cancer agent.
format	Conference or Workshop Item
author	Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser
author_facet	Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser
author_sort	Wan Sulaiman, Wan Mohd. Azizi
title	Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
title_short	Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
title_full	Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
title_fullStr	Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
title_full_unstemmed	Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
title_sort	anti-angiogenic and toxicity effects of derris trifoliata extract in zebrafish embryo
publishDate	2018
url	http://irep.iium.edu.my/69896/ http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf
first_indexed	2023-09-18T21:39:13Z
last_indexed	2023-09-18T21:39:13Z
_version_	1777413027051601920

Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo

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