$Microbiological study of etiological pathogen in early infection of open fracture in orthopedics$

Microbiological study of etiological pathogen in early infection of open fracture in orthopedics

Introduction: Infection is a dreaded complication of open fracture in the field of orthopaedics. This study was conducted to evaluate the susceptibility of microorganism involved in early infection of open fractures to current prophylactic antibiotics practice and determine the association of variou...

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Main Authors:	Tai, Ken Meng, Sulong, Ahmad Fadzli, Mohd Yusof, Nazri
Format:	Article
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018
Subjects:	RB Pathology RD701 Orthopedics RD92 Wounds and injuries
Online Access:	http://irep.iium.edu.my/69621/ http://irep.iium.edu.my/69621/ http://irep.iium.edu.my/69621/1/Microbiological%20Study%20of%20Etiological%20Pathogen%20in%20Early%20Infection%20of%20Open%20Fracture%20in%20Orthopedics%20MRS%202018.pdf

id	iium-69621
recordtype	eprints
spelling	iium-696212019-01-14T01:03:09Z http://irep.iium.edu.my/69621/ Microbiological study of etiological pathogen in early infection of open fracture in orthopedics Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri RB Pathology RD701 Orthopedics RD92 Wounds and injuries Introduction: Infection is a dreaded complication of open fracture in the field of orthopaedics. This study was conducted to evaluate the susceptibility of microorganism involved in early infection of open fractures to current prophylactic antibiotics practice and determine the association of various characteristics to the resistance of such microorganisms. Materials and Methods: This cross sectional study was conducted from January 2015 to December 2017 in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia. A total of 179 cases were collected from the operating record with 110 cases fulfilling the inclusion and exclusion criteria. The patients underwent routine debridement where culture and sensitivity were followed up. Previous notes were traced to identify the various risk factors involved and evaluated against resistance of microorganism. Statistical analysis was done with SPSS version 23 applying Pearson chi-square tests and Fisher's exact test. Results: Admission to intensive care unit, blood transfusion, antibiotic regime and duration, fracture grade, injury severity score and duration of admission were all significantly associated with resistance of microorganism (p < 0.0001). This study also demonstrated 65.9% predominance of Gram-negative microorganisms. These gram-negative microorganisms were seen more in higher fracture grades, injury severity score, and longer duration of admission or antibiotics prescribed. The overall resistance to cefuroxime and gentamicin were 68.6% and 36.9% respectively. Conclusion: The shift of microorganism species to gram-negative and the high rate of resistance suggested that current antibiotic guidelines and regime needed to be fine-tuned to achieve optimal results in managing open fracture. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018-12-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69621/1/Microbiological%20Study%20of%20Etiological%20Pathogen%20in%20Early%20Infection%20of%20Open%20Fracture%20in%20Orthopedics%20MRS%202018.pdf Tai, Ken Meng and Sulong, Ahmad Fadzli and Mohd Yusof, Nazri (2018) Microbiological study of etiological pathogen in early infection of open fracture in orthopedics. The International Medical Journal Malaysia, 17 (Supplementary Issue No. 1). p. 22. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology RD701 Orthopedics RD92 Wounds and injuries
spellingShingle	RB Pathology RD701 Orthopedics RD92 Wounds and injuries Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
description	Introduction: Infection is a dreaded complication of open fracture in the field of orthopaedics. This study was conducted to evaluate the susceptibility of microorganism involved in early infection of open fractures to current prophylactic antibiotics practice and determine the association of various characteristics to the resistance of such microorganisms. Materials and Methods: This cross sectional study was conducted from January 2015 to December 2017 in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia. A total of 179 cases were collected from the operating record with 110 cases fulfilling the inclusion and exclusion criteria. The patients underwent routine debridement where culture and sensitivity were followed up. Previous notes were traced to identify the various risk factors involved and evaluated against resistance of microorganism. Statistical analysis was done with SPSS version 23 applying Pearson chi-square tests and Fisher's exact test. Results: Admission to intensive care unit, blood transfusion, antibiotic regime and duration, fracture grade, injury severity score and duration of admission were all significantly associated with resistance of microorganism (p < 0.0001). This study also demonstrated 65.9% predominance of Gram-negative microorganisms. These gram-negative microorganisms were seen more in higher fracture grades, injury severity score, and longer duration of admission or antibiotics prescribed. The overall resistance to cefuroxime and gentamicin were 68.6% and 36.9% respectively. Conclusion: The shift of microorganism species to gram-negative and the high rate of resistance suggested that current antibiotic guidelines and regime needed to be fine-tuned to achieve optimal results in managing open fracture.
format	Article
author	Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri
author_facet	Tai, Ken Meng Sulong, Ahmad Fadzli Mohd Yusof, Nazri
author_sort	Tai, Ken Meng
title	Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
title_short	Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
title_full	Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
title_fullStr	Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
title_full_unstemmed	Microbiological study of etiological pathogen in early infection of open fracture in orthopedics
title_sort	microbiological study of etiological pathogen in early infection of open fracture in orthopedics
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/69621/ http://irep.iium.edu.my/69621/ http://irep.iium.edu.my/69621/1/Microbiological%20Study%20of%20Etiological%20Pathogen%20in%20Early%20Infection%20of%20Open%20Fracture%20in%20Orthopedics%20MRS%202018.pdf
first_indexed	2023-09-18T21:38:49Z
last_indexed	2023-09-18T21:38:49Z
_version_	1777413001785114624

Microbiological study of etiological pathogen in early infection of open fracture in orthopedics

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