Incidence, patterns, and predictors of locoregional recurrence in colon cancer

Background. Locoregional recurrence (LR) in colon cancer is uncommon but often incurable, while the factors associated with it are unclear. The purpose of this study was to identify patterns and predictors of LR after curative resection for colon cancer. Methods. All patients who underwent colo...

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Main Authors:	Liska, David, Stocchi, Luca L., Karagkounis, Georgios, Elagili, Faisal, Dietz, David W, Kalady, Matthew F., Kesler, Hermann P., Remzi, Feza H., Church, James Michael
Format:	Article
Language:	English English
Published:	Springer Nature 2017
Subjects:	RD Surgery
Online Access:	http://irep.iium.edu.my/69605/ http://irep.iium.edu.my/69605/ http://irep.iium.edu.my/69605/ http://irep.iium.edu.my/69605/7/69605_Incidence%2C%20Patterns%2C%20and%20Predictors%20of%20Locoregional%20_article.pdf http://irep.iium.edu.my/69605/8/69605_Incidence%2C%20Patterns%2C%20and%20Predictors%20of%20Locoregional%20_scopus.pdf

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recordtype	eprints
spelling	iium-696052019-03-22T09:01:03Z http://irep.iium.edu.my/69605/ Incidence, patterns, and predictors of locoregional recurrence in colon cancer Liska, David Stocchi, Luca L. Karagkounis, Georgios Elagili, Faisal Dietz, David W Kalady, Matthew F. Kesler, Hermann P. Remzi, Feza H. Church, James Michael RD Surgery Background. Locoregional recurrence (LR) in colon cancer is uncommon but often incurable, while the factors associated with it are unclear. The purpose of this study was to identify patterns and predictors of LR after curative resection for colon cancer. Methods. All patients who underwent colon cancer resection with curative intent between 1994 and 2008 at a tertiary referral center were identified from a prospectively maintained institutional database. The association of LR with clinicopathologic and treatment characteristics was determined using univariable and multivariable analyses. Results. A total of 1397 patients were included with a median follow-up of 7.8 years; 635 (45%) were female, and the median age was 69 years. LR was detected in 61 (4.4%) patients. Median time to LR was 21 months. On multivariable analysis, the independent predictors of LR were disease stage [hazard ratio (HR) for Stage II 4.6, 95% confidence interval (CI) 1.05–19.9, HR for Stage III 10.8, 95% CI 2.6–45.8], bowel obstruction (HR 3.8, 95% CI 1.9–7.4), margin involvement (HR 4.1, 95% CI 1.9–8.6), lymphovascular invasion (HR 1.9, 95% CI 1.06–3.5), and local tumor invasion (fixation to another structure, perforation, or presence of associated fistula, HR 2.2, 95% CI 1.1–4.5). Adjuvant chemotherapy was not associated with reduced LR in patients with either Stage II or Stage III tumors. Conclusions. Adherence to oncologic surgical principles in colon cancer resection results in low rates of LR, which is associated with tumor-dependent factors. Recognition of these factors can help to determine appropriate postoperative surveillance. Springer Nature 2017-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69605/7/69605_Incidence%2C%20Patterns%2C%20and%20Predictors%20of%20Locoregional%20_article.pdf application/pdf en http://irep.iium.edu.my/69605/8/69605_Incidence%2C%20Patterns%2C%20and%20Predictors%20of%20Locoregional%20_scopus.pdf Liska, David and Stocchi, Luca L. and Karagkounis, Georgios and Elagili, Faisal and Dietz, David W and Kalady, Matthew F. and Kesler, Hermann P. and Remzi, Feza H. and Church, James Michael (2017) Incidence, patterns, and predictors of locoregional recurrence in colon cancer. Annals of Surgical Oncology, 24 (4). pp. 1093-1099. ISSN 1068-9265 E-ISSN 1534-4681 https://link.springer.com/article/10.1245%2Fs10434-016-5643-z 10.1245/s10434-016-5643-z
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RD Surgery
spellingShingle	RD Surgery Liska, David Stocchi, Luca L. Karagkounis, Georgios Elagili, Faisal Dietz, David W Kalady, Matthew F. Kesler, Hermann P. Remzi, Feza H. Church, James Michael Incidence, patterns, and predictors of locoregional recurrence in colon cancer
description	Background. Locoregional recurrence (LR) in colon cancer is uncommon but often incurable, while the factors associated with it are unclear. The purpose of this study was to identify patterns and predictors of LR after curative resection for colon cancer. Methods. All patients who underwent colon cancer resection with curative intent between 1994 and 2008 at a tertiary referral center were identified from a prospectively maintained institutional database. The association of LR with clinicopathologic and treatment characteristics was determined using univariable and multivariable analyses. Results. A total of 1397 patients were included with a median follow-up of 7.8 years; 635 (45%) were female, and the median age was 69 years. LR was detected in 61 (4.4%) patients. Median time to LR was 21 months. On multivariable analysis, the independent predictors of LR were disease stage [hazard ratio (HR) for Stage II 4.6, 95% confidence interval (CI) 1.05–19.9, HR for Stage III 10.8, 95% CI 2.6–45.8], bowel obstruction (HR 3.8, 95% CI 1.9–7.4), margin involvement (HR 4.1, 95% CI 1.9–8.6), lymphovascular invasion (HR 1.9, 95% CI 1.06–3.5), and local tumor invasion (fixation to another structure, perforation, or presence of associated fistula, HR 2.2, 95% CI 1.1–4.5). Adjuvant chemotherapy was not associated with reduced LR in patients with either Stage II or Stage III tumors. Conclusions. Adherence to oncologic surgical principles in colon cancer resection results in low rates of LR, which is associated with tumor-dependent factors. Recognition of these factors can help to determine appropriate postoperative surveillance.
format	Article
author	Liska, David Stocchi, Luca L. Karagkounis, Georgios Elagili, Faisal Dietz, David W Kalady, Matthew F. Kesler, Hermann P. Remzi, Feza H. Church, James Michael
author_facet	Liska, David Stocchi, Luca L. Karagkounis, Georgios Elagili, Faisal Dietz, David W Kalady, Matthew F. Kesler, Hermann P. Remzi, Feza H. Church, James Michael
author_sort	Liska, David
title	Incidence, patterns, and predictors of locoregional recurrence in colon cancer
title_short	Incidence, patterns, and predictors of locoregional recurrence in colon cancer
title_full	Incidence, patterns, and predictors of locoregional recurrence in colon cancer
title_fullStr	Incidence, patterns, and predictors of locoregional recurrence in colon cancer
title_full_unstemmed	Incidence, patterns, and predictors of locoregional recurrence in colon cancer
title_sort	incidence, patterns, and predictors of locoregional recurrence in colon cancer
publisher	Springer Nature
publishDate	2017
url	http://irep.iium.edu.my/69605/ http://irep.iium.edu.my/69605/ http://irep.iium.edu.my/69605/ http://irep.iium.edu.my/69605/7/69605_Incidence%2C%20Patterns%2C%20and%20Predictors%20of%20Locoregional%20_article.pdf http://irep.iium.edu.my/69605/8/69605_Incidence%2C%20Patterns%2C%20and%20Predictors%20of%20Locoregional%20_scopus.pdf
first_indexed	2023-09-18T21:38:49Z
last_indexed	2023-09-18T21:38:49Z
_version_	1777413001348907008

Incidence, patterns, and predictors of locoregional recurrence in colon cancer

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