Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis

Malaysia is an endemic hot spot for melioidosis; however, a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies...

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Main Authors:	Nathan, Sheila Nathan, Chieng, Sylvia Chieng, Kingsley, Paul Vijay Kingsley, Mohan, Anand Mohan, Podin, Yuwana Podin, Ooi, Mong-How Ooi, Mariappan, Vanitha Mariappan, Vellasamy, Kumutha Malar Vellasamy, Vadivelu, Jamuna Vadivelu, Daim, Sylvia Daim, How, Soon Hin
Format:	Article
Language:	English
Published:	MDPI 2018
Subjects:	RC Internal medicine RC111 Infectious and Parasitic Diseases
Online Access:	http://irep.iium.edu.my/69531/ http://irep.iium.edu.my/69531/ http://irep.iium.edu.my/69531/ http://irep.iium.edu.my/69531/1/69531_%20Melioidosis%20in%20Malaysia%20Incidence%2C%20clinical%20challenges%20and%20advances_article.pdf

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recordtype	eprints
spelling	iium-695312019-02-15T07:51:59Z http://irep.iium.edu.my/69531/ Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis Nathan, Sheila Nathan Chieng, Sylvia Chieng Kingsley, Paul Vijay Kingsley Mohan, Anand Mohan Podin, Yuwana Podin Ooi, Mong-How Ooi Mariappan, Vanitha Mariappan Vellasamy, Kumutha Malar Vellasamy Vadivelu, Jamuna Vadivelu Daim, Sylvia Daim How, Soon Hin RC Internal medicine RC111 Infectious and Parasitic Diseases Malaysia is an endemic hot spot for melioidosis; however, a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies, risk factors, and mortality rates from available literature and case reports. Clinical patterns of melioidosis are generally consistent with those from South and Southeast Asia in terms of common primary presentations with diabetes as a major risk factor. Early diagnosis and appropriate management of Malaysian patients is a key limiting factor, which needs to be addressed to reduce serious complications and high mortality and recurrence rates. Promoting awareness among the local healthcare personnel is crucial to improving diagnostics and early treatment, as well as educating the Malaysian public on disease symptoms and risk factors. A further matter of urgency is the need to make this a notiﬁable disease and the establishment of a national melioidosis registry. We also highlight local studies on the causative agent, Burkholderiapseudomallei, with regards to bacteriology and identiﬁcation of virulence factors as well as ﬁndings from host–pathogen interaction studies. Collectively, these studies have uncovered new correlations and insights for further understanding of the disease. MDPI 2018-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69531/1/69531_%20Melioidosis%20in%20Malaysia%20Incidence%2C%20clinical%20challenges%20and%20advances_article.pdf Nathan, Sheila Nathan and Chieng, Sylvia Chieng and Kingsley, Paul Vijay Kingsley and Mohan, Anand Mohan and Podin, Yuwana Podin and Ooi, Mong-How Ooi and Mariappan, Vanitha Mariappan and Vellasamy, Kumutha Malar Vellasamy and Vadivelu, Jamuna Vadivelu and Daim, Sylvia Daim and How, Soon Hin (2018) Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis. Tropical Medicine and Infectious Disease, 3 (1). pp. 1-19. E-ISSN 2414-6366 http://www.mdpi.com/journal/tropicalmed 10.3390/tropicalmed3010025
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine RC111 Infectious and Parasitic Diseases
spellingShingle	RC Internal medicine RC111 Infectious and Parasitic Diseases Nathan, Sheila Nathan Chieng, Sylvia Chieng Kingsley, Paul Vijay Kingsley Mohan, Anand Mohan Podin, Yuwana Podin Ooi, Mong-How Ooi Mariappan, Vanitha Mariappan Vellasamy, Kumutha Malar Vellasamy Vadivelu, Jamuna Vadivelu Daim, Sylvia Daim How, Soon Hin Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis
description	Malaysia is an endemic hot spot for melioidosis; however, a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies, risk factors, and mortality rates from available literature and case reports. Clinical patterns of melioidosis are generally consistent with those from South and Southeast Asia in terms of common primary presentations with diabetes as a major risk factor. Early diagnosis and appropriate management of Malaysian patients is a key limiting factor, which needs to be addressed to reduce serious complications and high mortality and recurrence rates. Promoting awareness among the local healthcare personnel is crucial to improving diagnostics and early treatment, as well as educating the Malaysian public on disease symptoms and risk factors. A further matter of urgency is the need to make this a notiﬁable disease and the establishment of a national melioidosis registry. We also highlight local studies on the causative agent, Burkholderiapseudomallei, with regards to bacteriology and identiﬁcation of virulence factors as well as ﬁndings from host–pathogen interaction studies. Collectively, these studies have uncovered new correlations and insights for further understanding of the disease.
format	Article
author	Nathan, Sheila Nathan Chieng, Sylvia Chieng Kingsley, Paul Vijay Kingsley Mohan, Anand Mohan Podin, Yuwana Podin Ooi, Mong-How Ooi Mariappan, Vanitha Mariappan Vellasamy, Kumutha Malar Vellasamy Vadivelu, Jamuna Vadivelu Daim, Sylvia Daim How, Soon Hin
author_facet	Nathan, Sheila Nathan Chieng, Sylvia Chieng Kingsley, Paul Vijay Kingsley Mohan, Anand Mohan Podin, Yuwana Podin Ooi, Mong-How Ooi Mariappan, Vanitha Mariappan Vellasamy, Kumutha Malar Vellasamy Vadivelu, Jamuna Vadivelu Daim, Sylvia Daim How, Soon Hin
author_sort	Nathan, Sheila Nathan
title	Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis
title_short	Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis
title_full	Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis
title_fullStr	Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis
title_full_unstemmed	Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis
title_sort	melioidosis in malaysia: incidence, clinical challenges and advances in understanding pathogenesis
publisher	MDPI
publishDate	2018
url	http://irep.iium.edu.my/69531/ http://irep.iium.edu.my/69531/ http://irep.iium.edu.my/69531/ http://irep.iium.edu.my/69531/1/69531_%20Melioidosis%20in%20Malaysia%20Incidence%2C%20clinical%20challenges%20and%20advances_article.pdf
first_indexed	2023-09-18T21:38:42Z
last_indexed	2023-09-18T21:38:42Z
_version_	1777412994229075968

Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis

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