Red cell antibody screening: a single centre experience

The Transfusion Unit of International Islamic University Medical Centre (IIUM MC) performs screening for red cell antibodies for all patients who are to be or might be transfused with red cell components. There are two types of red cell antibodies, the alloantibodies and autoantibodies. While the re...

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Main Authors:	Muhammad, Siti Aesah @ Naznin, Zainal Azhar, Syifa, Meor Jamaludin, Wan Husna Barakah, A. Talib, Norlelawati, Hamdan, Asmah Hanim, Abd. Fuaat, Azliana, Abdullah, Nor Zamzila, Shaik Daud, Shaik Farizan
Format:	Article
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/69378/ http://irep.iium.edu.my/69378/ http://irep.iium.edu.my/69378/2/MRS2018-34.pdf

id	iium-69378
recordtype	eprints
spelling	iium-693782019-01-18T07:57:50Z http://irep.iium.edu.my/69378/ Red cell antibody screening: a single centre experience Muhammad, Siti Aesah @ Naznin Zainal Azhar, Syifa Meor Jamaludin, Wan Husna Barakah A. Talib, Norlelawati Hamdan, Asmah Hanim Abd. Fuaat, Azliana Abdullah, Nor Zamzila Shaik Daud, Shaik Farizan RB Pathology The Transfusion Unit of International Islamic University Medical Centre (IIUM MC) performs screening for red cell antibodies for all patients who are to be or might be transfused with red cell components. There are two types of red cell antibodies, the alloantibodies and autoantibodies. While the red cell autoantibodies are produced against self-antigen, the alloantibodies are the results of sensitization through transfusion or pregnancies. These antibodies are implicated in haemolytic transfusion reactions. This retrospective study examines the prevalence of red cell antibodies among patients of IIUM MC. Materials and Methods: All group cross matching and group screen and hold testing performed in IIUM MC from January 2017 to June 2018 were reviewed. Results: In total, samples of 3,712 patients were subjected to antibody screening using gel card. Twelve patients (0.32%) had positive antibody screening tests. The age ranged from 17 to 77 years. Nine (75%) patients were females. Four patients had positivity with Screening Cell I, one patient with Screening Cell II and III respectively. In the remaining patients (6/12) the antibody screening was positive for both Screening Cell I and II. In nine patients (0.24%) alloantibodies were identified, with six exhibiting multiple antibodies. The alloantibodies identified include anti-Le(a), anti-Le(b), anti-Kp(a), anti-C, anti-c, anti-E and anti-e. In three patients autoantibodies with no specificities were detected. Conclusion: Although the prevalence of red cell antibodies, specifically the alloantibodies is lower compared to other studies, the finding further reiterates the need to screen for unexpected red cell antibodies prior to red cell transfusion. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018-12-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69378/2/MRS2018-34.pdf Muhammad, Siti Aesah @ Naznin and Zainal Azhar, Syifa and Meor Jamaludin, Wan Husna Barakah and A. Talib, Norlelawati and Hamdan, Asmah Hanim and Abd. Fuaat, Azliana and Abdullah, Nor Zamzila and Shaik Daud, Shaik Farizan (2018) Red cell antibody screening: a single centre experience. International Medical Journal Malaysia, 17 (Supplementary Issue No 1). p. 33. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/vol_17_no_3_supp_1/MRS2018-34.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Muhammad, Siti Aesah @ Naznin Zainal Azhar, Syifa Meor Jamaludin, Wan Husna Barakah A. Talib, Norlelawati Hamdan, Asmah Hanim Abd. Fuaat, Azliana Abdullah, Nor Zamzila Shaik Daud, Shaik Farizan Red cell antibody screening: a single centre experience
description	The Transfusion Unit of International Islamic University Medical Centre (IIUM MC) performs screening for red cell antibodies for all patients who are to be or might be transfused with red cell components. There are two types of red cell antibodies, the alloantibodies and autoantibodies. While the red cell autoantibodies are produced against self-antigen, the alloantibodies are the results of sensitization through transfusion or pregnancies. These antibodies are implicated in haemolytic transfusion reactions. This retrospective study examines the prevalence of red cell antibodies among patients of IIUM MC. Materials and Methods: All group cross matching and group screen and hold testing performed in IIUM MC from January 2017 to June 2018 were reviewed. Results: In total, samples of 3,712 patients were subjected to antibody screening using gel card. Twelve patients (0.32%) had positive antibody screening tests. The age ranged from 17 to 77 years. Nine (75%) patients were females. Four patients had positivity with Screening Cell I, one patient with Screening Cell II and III respectively. In the remaining patients (6/12) the antibody screening was positive for both Screening Cell I and II. In nine patients (0.24%) alloantibodies were identified, with six exhibiting multiple antibodies. The alloantibodies identified include anti-Le(a), anti-Le(b), anti-Kp(a), anti-C, anti-c, anti-E and anti-e. In three patients autoantibodies with no specificities were detected. Conclusion: Although the prevalence of red cell antibodies, specifically the alloantibodies is lower compared to other studies, the finding further reiterates the need to screen for unexpected red cell antibodies prior to red cell transfusion.
format	Article
author	Muhammad, Siti Aesah @ Naznin Zainal Azhar, Syifa Meor Jamaludin, Wan Husna Barakah A. Talib, Norlelawati Hamdan, Asmah Hanim Abd. Fuaat, Azliana Abdullah, Nor Zamzila Shaik Daud, Shaik Farizan
author_facet	Muhammad, Siti Aesah @ Naznin Zainal Azhar, Syifa Meor Jamaludin, Wan Husna Barakah A. Talib, Norlelawati Hamdan, Asmah Hanim Abd. Fuaat, Azliana Abdullah, Nor Zamzila Shaik Daud, Shaik Farizan
author_sort	Muhammad, Siti Aesah @ Naznin
title	Red cell antibody screening: a single centre experience
title_short	Red cell antibody screening: a single centre experience
title_full	Red cell antibody screening: a single centre experience
title_fullStr	Red cell antibody screening: a single centre experience
title_full_unstemmed	Red cell antibody screening: a single centre experience
title_sort	red cell antibody screening: a single centre experience
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/69378/ http://irep.iium.edu.my/69378/ http://irep.iium.edu.my/69378/2/MRS2018-34.pdf
first_indexed	2023-09-18T21:38:28Z
last_indexed	2023-09-18T21:38:28Z
_version_	1777412980336492544

Red cell antibody screening: a single centre experience

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