Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model

Introduction: Decreased cerebral blood supply to the brain can generate a condition of chronic cerebral hypoperfusion, which is one of the pathophysiological mechanisms of neuronal degeneration and cognitive impairment in Alzheimer’s disease. This study aimed to evaluate the potential neuroprotecti...

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Main Authors:	Saleh Alruhaimi, Hulol, Allow, Ahmed Kaid Naji, Bahbah, Mohammad Nasser Hamed Mahmoud, Buyong, Zunariah, Rahman, Shaikh Mizanur, Mohamed, Wael Mohamed Yousef
Format:	Article
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/69262/ http://irep.iium.edu.my/69262/ http://irep.iium.edu.my/69262/1/MRS2018-49%20Neuroprotective%20Effect%20of%20oral%20Administration%20of%20Trigonella%20Foenum-Graecum%20on%20Cerebral%20Hypoperfusion%20in%20Rat%20Model.pdf

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spelling	iium-692622019-01-18T00:59:55Z http://irep.iium.edu.my/69262/ Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Bahbah, Mohammad Nasser Hamed Mahmoud Buyong, Zunariah Rahman, Shaikh Mizanur Mohamed, Wael Mohamed Yousef R Medicine (General) Introduction: Decreased cerebral blood supply to the brain can generate a condition of chronic cerebral hypoperfusion, which is one of the pathophysiological mechanisms of neuronal degeneration and cognitive impairment in Alzheimer’s disease. This study aimed to evaluate the potential neuroprotective effects of Trigonella foenum graecum seeds on chronic cerebral hypoperfusion in a rat model. Materials and Methods: Chronic cerebral hypoperfusion was induced by permanent bilateral ligation of the common carotid arteries (a two-vessel occlusion, 2VO) in male Sprague–Dawley rats. The experimental groups were divided into three groups (11 rats/group): i) sham (control) group; ii) 2VO group without any treatment; and iii) 2VO group that was administered orally with the Trigonella foenum graecum extract (100 mg/kg/day) by oral gavage from 3 days before the date of 2VO surgery and continued daily until the end of the 8th postoperative week. Spatial memory performance was assessed by the Morris water maze test. Malondialdehyde and C-reactive protein (CRP) concentration, superoxide dismutase and glutathione activities were measured in serum after 8 weeks from 2VO injury. Results: Chronic cerebral hypoperfusion rats resulted in spatial memory impairments. This behavioral dysfunction was accompanied by decreasing superoxide dismutase and glutathione activities, and increasing malondialdehyde and CRP levels in serum. Oral administration of Trigonella foenum graecum extract significantly improved the memory impairment, enhanced antioxidant enzyme activities, and decreased the malondialdehyde and CRP levels to near normal levels. Conclusion: The potential activity offered by Trigonella foenum graecum extract showed the neuroprotective effect that may be beneficial in cerebrovascular type dementia. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018-12-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69262/1/MRS2018-49%20Neuroprotective%20Effect%20of%20oral%20Administration%20of%20Trigonella%20Foenum-Graecum%20on%20Cerebral%20Hypoperfusion%20in%20Rat%20Model.pdf Saleh Alruhaimi, Hulol and Allow, Ahmed Kaid Naji and Bahbah, Mohammad Nasser Hamed Mahmoud and Buyong, Zunariah and Rahman, Shaikh Mizanur and Mohamed, Wael Mohamed Yousef (2018) Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model. International Medical Journal Malaysia, 17 (Supplementary Issue 1). p. 48. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/vol_17_no_3_supp_1/MRS2018-49.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Bahbah, Mohammad Nasser Hamed Mahmoud Buyong, Zunariah Rahman, Shaikh Mizanur Mohamed, Wael Mohamed Yousef Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model
description	Introduction: Decreased cerebral blood supply to the brain can generate a condition of chronic cerebral hypoperfusion, which is one of the pathophysiological mechanisms of neuronal degeneration and cognitive impairment in Alzheimer’s disease. This study aimed to evaluate the potential neuroprotective effects of Trigonella foenum graecum seeds on chronic cerebral hypoperfusion in a rat model. Materials and Methods: Chronic cerebral hypoperfusion was induced by permanent bilateral ligation of the common carotid arteries (a two-vessel occlusion, 2VO) in male Sprague–Dawley rats. The experimental groups were divided into three groups (11 rats/group): i) sham (control) group; ii) 2VO group without any treatment; and iii) 2VO group that was administered orally with the Trigonella foenum graecum extract (100 mg/kg/day) by oral gavage from 3 days before the date of 2VO surgery and continued daily until the end of the 8th postoperative week. Spatial memory performance was assessed by the Morris water maze test. Malondialdehyde and C-reactive protein (CRP) concentration, superoxide dismutase and glutathione activities were measured in serum after 8 weeks from 2VO injury. Results: Chronic cerebral hypoperfusion rats resulted in spatial memory impairments. This behavioral dysfunction was accompanied by decreasing superoxide dismutase and glutathione activities, and increasing malondialdehyde and CRP levels in serum. Oral administration of Trigonella foenum graecum extract significantly improved the memory impairment, enhanced antioxidant enzyme activities, and decreased the malondialdehyde and CRP levels to near normal levels. Conclusion: The potential activity offered by Trigonella foenum graecum extract showed the neuroprotective effect that may be beneficial in cerebrovascular type dementia.
format	Article
author	Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Bahbah, Mohammad Nasser Hamed Mahmoud Buyong, Zunariah Rahman, Shaikh Mizanur Mohamed, Wael Mohamed Yousef
author_facet	Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Bahbah, Mohammad Nasser Hamed Mahmoud Buyong, Zunariah Rahman, Shaikh Mizanur Mohamed, Wael Mohamed Yousef
author_sort	Saleh Alruhaimi, Hulol
title	Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model
title_short	Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model
title_full	Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model
title_fullStr	Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model
title_full_unstemmed	Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model
title_sort	neuroprotective effect of oral administration of trigonella foenum-graecum on chronic cerebral hypoperfusion in rat model
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/69262/ http://irep.iium.edu.my/69262/ http://irep.iium.edu.my/69262/1/MRS2018-49%20Neuroprotective%20Effect%20of%20oral%20Administration%20of%20Trigonella%20Foenum-Graecum%20on%20Cerebral%20Hypoperfusion%20in%20Rat%20Model.pdf
first_indexed	2023-09-18T21:38:18Z
last_indexed	2023-09-18T21:38:18Z
_version_	1777412969717563392

Neuroprotective effect of oral administration of Trigonella Foenum-Graecum on chronic cerebral hypoperfusion in rat model

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