Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology

Fish gelatin nanoparticle is produced using Tilapia fish skin for the first time by the two-step desolvation method. Fish gelatin is chosen for producing gelatin nanoparticles because no experiment have been done in using fish gelatin and to counter the problem associated with the use of mammalian g...

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Main Authors:	Subara, Deni, Jaswir, Irwandi, Al-Khatib, Ma An Fahmi Rashid, Ibrahim Ali, Noorbatcha
Format:	Article
Language:	English English
Published:	Institute of Physics Publishing 2018
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/69202/ http://irep.iium.edu.my/69202/ http://irep.iium.edu.my/69202/ http://irep.iium.edu.my/69202/1/69202_Synthesis%20of%20fish%20gelatin%20nanoparticles%20and.pdf http://irep.iium.edu.my/69202/2/69202_Synthesis%20of%20fish%20gelatin%20nanoparticles%20and_SCOPUS.pdf

id	iium-69202
recordtype	eprints
spelling	iium-692022019-01-16T04:07:17Z http://irep.iium.edu.my/69202/ Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology Subara, Deni Jaswir, Irwandi Al-Khatib, Ma An Fahmi Rashid Ibrahim Ali, Noorbatcha TP248.13 Biotechnology Fish gelatin nanoparticle is produced using Tilapia fish skin for the first time by the two-step desolvation method. Fish gelatin is chosen for producing gelatin nanoparticles because no experiment have been done in using fish gelatin and to counter the problem associated with the use of mammalian gelatin, such as bovine spongiform encephalopathy disease. The effects of several factors on the particle size such as pH, acetone concentration, glutaraldehyde volume, stirring speed and stirring time are evaluated. Optimum conditions for the formation of gelatin nanoparticles are obtained using response surface method. Fish gelatin nanoparticles with optimum size of 198.46 ± 6.1 nm can be produced using pH of 2.45, acetone percentage of 16% (vol%), glutaraldehyde 400 μ, stirring speed of 600 rpm, and stirring time for 6 h. The thermogram and molecular interaction of fish gelatin and fish gelatin nanoparticles are characterized using DSC and FTIR. In vitro drug release kinetic is examined using 5-fluorouracil as the model drug. The entrapment efficiency of 5-fluouracil as model drug is determined to be 40%. Fish gelatin could be used as a good alternative drug carrier for mammalian gelatin. Institute of Physics Publishing 2018-12-13 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69202/1/69202_Synthesis%20of%20fish%20gelatin%20nanoparticles%20and.pdf application/pdf en http://irep.iium.edu.my/69202/2/69202_Synthesis%20of%20fish%20gelatin%20nanoparticles%20and_SCOPUS.pdf Subara, Deni and Jaswir, Irwandi and Al-Khatib, Ma An Fahmi Rashid and Ibrahim Ali, Noorbatcha (2018) Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology. Advances in Natural Sciences: Nanoscience and Nanotechnology, 9. 045014-1-13. E-ISSN 2043-6262 http://iopscience.iop.org/article/10.1088/2043-6254/aae988/pdf https://doi.org/10.1088/2043-6254/aae988
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Subara, Deni Jaswir, Irwandi Al-Khatib, Ma An Fahmi Rashid Ibrahim Ali, Noorbatcha Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
description	Fish gelatin nanoparticle is produced using Tilapia fish skin for the first time by the two-step desolvation method. Fish gelatin is chosen for producing gelatin nanoparticles because no experiment have been done in using fish gelatin and to counter the problem associated with the use of mammalian gelatin, such as bovine spongiform encephalopathy disease. The effects of several factors on the particle size such as pH, acetone concentration, glutaraldehyde volume, stirring speed and stirring time are evaluated. Optimum conditions for the formation of gelatin nanoparticles are obtained using response surface method. Fish gelatin nanoparticles with optimum size of 198.46 ± 6.1 nm can be produced using pH of 2.45, acetone percentage of 16% (vol%), glutaraldehyde 400 μ, stirring speed of 600 rpm, and stirring time for 6 h. The thermogram and molecular interaction of fish gelatin and fish gelatin nanoparticles are characterized using DSC and FTIR. In vitro drug release kinetic is examined using 5-fluorouracil as the model drug. The entrapment efficiency of 5-fluouracil as model drug is determined to be 40%. Fish gelatin could be used as a good alternative drug carrier for mammalian gelatin.
format	Article
author	Subara, Deni Jaswir, Irwandi Al-Khatib, Ma An Fahmi Rashid Ibrahim Ali, Noorbatcha
author_facet	Subara, Deni Jaswir, Irwandi Al-Khatib, Ma An Fahmi Rashid Ibrahim Ali, Noorbatcha
author_sort	Subara, Deni
title	Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
title_short	Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
title_full	Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
title_fullStr	Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
title_full_unstemmed	Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
title_sort	synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology
publisher	Institute of Physics Publishing
publishDate	2018
url	http://irep.iium.edu.my/69202/ http://irep.iium.edu.my/69202/ http://irep.iium.edu.my/69202/ http://irep.iium.edu.my/69202/1/69202_Synthesis%20of%20fish%20gelatin%20nanoparticles%20and.pdf http://irep.iium.edu.my/69202/2/69202_Synthesis%20of%20fish%20gelatin%20nanoparticles%20and_SCOPUS.pdf
first_indexed	2023-09-18T21:38:14Z
last_indexed	2023-09-18T21:38:14Z
_version_	1777412964866850816

Synthesis of fish gelatin nanoparticles and their application for the drug delivery based on response surface methodology

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