Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result

Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result

Rationale: There is limited clinical research investigating nutritional adequacy on quality of life (QoL) among survivors in critical care. Methods: This is a prospective observational cohort study conducted among mechanically ventilated critically ill patients. Energy requirements were estimated b...

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Main Authors: Tah, PC, Vineya-Rai, HR, Poh, BK, Mat Nor, Mohd Basri, A.M., Hazreen, Kee, CC, K.Z., Mazuin, Z.Y., Lee, H., Mohd Shahnaz
Format: Article
Language:English
Published: Elsevier Inc 2018
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/68818/
http://irep.iium.edu.my/68818/
http://irep.iium.edu.my/68818/
http://irep.iium.edu.my/68818/1/clinical%20nutrition_aspen%202018.pdf
id iium-68818
recordtype eprints
spelling iium-688182019-01-04T02:21:20Z http://irep.iium.edu.my/68818/ Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result Tah, PC Vineya-Rai, HR Poh, BK Mat Nor, Mohd Basri A.M., Hazreen Kee, CC K.Z., Mazuin Z.Y., Lee H., Mohd Shahnaz R Medicine (General) Rationale: There is limited clinical research investigating nutritional adequacy on quality of life (QoL) among survivors in critical care. Methods: This is a prospective observational cohort study conducted among mechanically ventilated critically ill patients. Energy requirements were estimated by Indirect Calorimetry and protein requirements were estimated by 24-h urinary urea. Nutritional intake was recorded daily until death, discharge, or until 14th evaluable day. Eight domains of QoL were assessed by validated SF-36(v2) at six months post-ICU admission. Association between two groups (<70% and ≥70% of energy and protein requirement) with QoL was examined using logistic regression with adjustment for potential confounders. Results: This study aims to determine the association between energy and protein adequacy with QoL among critically ill patients. Of 154 patients, 71 patients (46.1%) were alive, 69 patients (44.8%) died and 14 patients (9.1%) gave no response at 6 months followup. Patient characteristics at follow-up: age 50.6±19.6 years; 62.0% male; body mass index 24.9 (22.3–28.7) kg/m2; APACHE II score 21.2±5.2. Mean QoL score was 58.6±15.9, with scores ≥53 indicating better QoL. Results showed patients with protein, but not energy, adequacy of ≥70% had potential trend towards better QoL though not statistically significant (adjusted OR 2.62; 95%CI 0.80- 8.53; p=0.11). Protein adequacy ≥70% significantly improved bodily pain status (p<0.05), but no significant difference was found in seven other domains of QoL. Conclusion: This preliminary result suggest higher protein adequacy improve Bodily Pain status and may potentially lead towards better overall QoL. We opine that earlier nutrition intervention may assist in improving QoL but needs further investigation. Elsevier Inc 2018-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68818/1/clinical%20nutrition_aspen%202018.pdf Tah, PC and Vineya-Rai, HR and Poh, BK and Mat Nor, Mohd Basri and A.M., Hazreen and Kee, CC and K.Z., Mazuin and Z.Y., Lee and H., Mohd Shahnaz (2018) Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result. Clinical Nutrition, 37 (Supplement 1). S300-S301. ISSN 0261-5614 https://www.clinicalnutritionjournal.com/article/S0261-5614(18)32330-6/pdf https://doi.org/10.1016/j.clnu.2018.06.2053
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Tah, PC
Vineya-Rai, HR
Poh, BK
Mat Nor, Mohd Basri
A.M., Hazreen
Kee, CC
K.Z., Mazuin
Z.Y., Lee
H., Mohd Shahnaz
Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
description Rationale: There is limited clinical research investigating nutritional adequacy on quality of life (QoL) among survivors in critical care. Methods: This is a prospective observational cohort study conducted among mechanically ventilated critically ill patients. Energy requirements were estimated by Indirect Calorimetry and protein requirements were estimated by 24-h urinary urea. Nutritional intake was recorded daily until death, discharge, or until 14th evaluable day. Eight domains of QoL were assessed by validated SF-36(v2) at six months post-ICU admission. Association between two groups (<70% and ≥70% of energy and protein requirement) with QoL was examined using logistic regression with adjustment for potential confounders. Results: This study aims to determine the association between energy and protein adequacy with QoL among critically ill patients. Of 154 patients, 71 patients (46.1%) were alive, 69 patients (44.8%) died and 14 patients (9.1%) gave no response at 6 months followup. Patient characteristics at follow-up: age 50.6±19.6 years; 62.0% male; body mass index 24.9 (22.3–28.7) kg/m2; APACHE II score 21.2±5.2. Mean QoL score was 58.6±15.9, with scores ≥53 indicating better QoL. Results showed patients with protein, but not energy, adequacy of ≥70% had potential trend towards better QoL though not statistically significant (adjusted OR 2.62; 95%CI 0.80- 8.53; p=0.11). Protein adequacy ≥70% significantly improved bodily pain status (p<0.05), but no significant difference was found in seven other domains of QoL. Conclusion: This preliminary result suggest higher protein adequacy improve Bodily Pain status and may potentially lead towards better overall QoL. We opine that earlier nutrition intervention may assist in improving QoL but needs further investigation.
format Article
author Tah, PC
Vineya-Rai, HR
Poh, BK
Mat Nor, Mohd Basri
A.M., Hazreen
Kee, CC
K.Z., Mazuin
Z.Y., Lee
H., Mohd Shahnaz
author_facet Tah, PC
Vineya-Rai, HR
Poh, BK
Mat Nor, Mohd Basri
A.M., Hazreen
Kee, CC
K.Z., Mazuin
Z.Y., Lee
H., Mohd Shahnaz
author_sort Tah, PC
title Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
title_short Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
title_full Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
title_fullStr Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
title_full_unstemmed Association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
title_sort association between energy and protein adequacy with quality of life in mechanically ventilated critically ill patients: a preliminary result
publisher Elsevier Inc
publishDate 2018
url http://irep.iium.edu.my/68818/
http://irep.iium.edu.my/68818/
http://irep.iium.edu.my/68818/
http://irep.iium.edu.my/68818/1/clinical%20nutrition_aspen%202018.pdf
first_indexed 2023-09-18T21:37:39Z
last_indexed 2023-09-18T21:37:39Z
_version_ 1777412928039813120

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