Biomedical applications of aromatic azo compounds

Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, azo compounds are reported as antibacterial, antiviral, antifungal and cytotoxic agents. They have the ability to be used as drug carriers, either by acting...

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Main Authors:	Ali, Yousaf, Abd Hamid, Shafida, Rashid, Umer
Format:	Article
Language:	English English English
Published:	Bentham Science 2018
Subjects:	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/68812/ http://irep.iium.edu.my/68812/ http://irep.iium.edu.my/68812/ http://irep.iium.edu.my/68812/7/68812_Biomedical%20applications%20of%20aromatic%20Azo_scopus.pdf http://irep.iium.edu.my/68812/12/68812_Biomedical%20applications%20of%20aromatic%20azo%20compounds_WOS.pdf http://irep.iium.edu.my/68812/13/68812_Biomedical%20applications%20of%20aromatic%20azo%20_article.pdf

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recordtype	eprints
spelling	iium-688122019-01-24T02:07:54Z http://irep.iium.edu.my/68812/ Biomedical applications of aromatic azo compounds Ali, Yousaf Abd Hamid, Shafida Rashid, Umer QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, azo compounds are reported as antibacterial, antiviral, antifungal and cytotoxic agents. They have the ability to be used as drug carriers, either by acting as a ‘cargo’ that entrap therapeutic agents or by prodrug approach. The drug is released by internal or external stimuli in the region of interest, as observed in colon-targeted drug delivery. Besides drug-like and drug carrier properties, a number of azo dyes are used in cellular staining to visualize cellular components and metabolic processes. However, the biological significance of azo compounds, especially in cancer chemotherapy, is still in its infancy. This may be linked to early findings that declared azo compounds as one of the possible causes of cancer and mutagenesis. Currently, researchers are screening the aromatic azo compounds for their potential biomedical use, including cancer diagnosis and therapy. In this review, we highlight the medical applications of azo compounds, particularly related to cancer research. The biomedical significance of cis-trans interchange and negative implications of azo compounds are also discussed in brief. Bentham Science 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68812/7/68812_Biomedical%20applications%20of%20aromatic%20Azo_scopus.pdf application/pdf en http://irep.iium.edu.my/68812/12/68812_Biomedical%20applications%20of%20aromatic%20azo%20compounds_WOS.pdf application/pdf en http://irep.iium.edu.my/68812/13/68812_Biomedical%20applications%20of%20aromatic%20azo%20_article.pdf Ali, Yousaf and Abd Hamid, Shafida and Rashid, Umer (2018) Biomedical applications of aromatic azo compounds. Mini-Reviews in Medicinal Chemistry, 18 (18). pp. 1548-1558. ISSN 1389-5575 E-ISSN 1875-5607 http://www.eurekaselect.com/162433/article 10.2174/1389557518666180524113111
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica Ali, Yousaf Abd Hamid, Shafida Rashid, Umer Biomedical applications of aromatic azo compounds
description	Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, azo compounds are reported as antibacterial, antiviral, antifungal and cytotoxic agents. They have the ability to be used as drug carriers, either by acting as a ‘cargo’ that entrap therapeutic agents or by prodrug approach. The drug is released by internal or external stimuli in the region of interest, as observed in colon-targeted drug delivery. Besides drug-like and drug carrier properties, a number of azo dyes are used in cellular staining to visualize cellular components and metabolic processes. However, the biological significance of azo compounds, especially in cancer chemotherapy, is still in its infancy. This may be linked to early findings that declared azo compounds as one of the possible causes of cancer and mutagenesis. Currently, researchers are screening the aromatic azo compounds for their potential biomedical use, including cancer diagnosis and therapy. In this review, we highlight the medical applications of azo compounds, particularly related to cancer research. The biomedical significance of cis-trans interchange and negative implications of azo compounds are also discussed in brief.
format	Article
author	Ali, Yousaf Abd Hamid, Shafida Rashid, Umer
author_facet	Ali, Yousaf Abd Hamid, Shafida Rashid, Umer
author_sort	Ali, Yousaf
title	Biomedical applications of aromatic azo compounds
title_short	Biomedical applications of aromatic azo compounds
title_full	Biomedical applications of aromatic azo compounds
title_fullStr	Biomedical applications of aromatic azo compounds
title_full_unstemmed	Biomedical applications of aromatic azo compounds
title_sort	biomedical applications of aromatic azo compounds
publisher	Bentham Science
publishDate	2018
url	http://irep.iium.edu.my/68812/ http://irep.iium.edu.my/68812/ http://irep.iium.edu.my/68812/ http://irep.iium.edu.my/68812/7/68812_Biomedical%20applications%20of%20aromatic%20Azo_scopus.pdf http://irep.iium.edu.my/68812/12/68812_Biomedical%20applications%20of%20aromatic%20azo%20compounds_WOS.pdf http://irep.iium.edu.my/68812/13/68812_Biomedical%20applications%20of%20aromatic%20azo%20_article.pdf
first_indexed	2023-09-18T21:37:38Z
last_indexed	2023-09-18T21:37:38Z
_version_	1777412927602556928

Biomedical applications of aromatic azo compounds

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