Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study

INTRODUCTION: Cellulite or lipodystrophy is a major aesthetical concern among women who want to look beautiful. OBJECTIVES: The aim of this study was to evaluate the effectiveness of a topical slimming and anti-cellulite cream containing caffeine on treatment of cellulite and other various skin par...

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Main Authors:	Mohamad, Nor Hakimah, Ab. Hadi, Hazrina, Doolaanea, Abd Almonem
Format:	Conference or Workshop Item
Language:	English English English
Published:	2018
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/68767/ http://irep.iium.edu.my/68767/1/PRCO10.pdf http://irep.iium.edu.my/68767/2/slide%20iprc%20HAKIMAH%20iium.pdf http://irep.iium.edu.my/68767/23/4IPRC.pdf

id	iium-68767
recordtype	eprints
spelling	iium-687672018-12-20T03:14:04Z http://irep.iium.edu.my/68767/ Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study Mohamad, Nor Hakimah Ab. Hadi, Hazrina Doolaanea, Abd Almonem RS192 Materia Medica-Pharmaceutical Technology INTRODUCTION: Cellulite or lipodystrophy is a major aesthetical concern among women who want to look beautiful. OBJECTIVES: The aim of this study was to evaluate the effectiveness of a topical slimming and anti-cellulite cream containing caffeine on treatment of cellulite and other various skin parameters on human volunteers. METHODS: Placebo and formulation containing 2.5% of caffeine were prepared and applied to the upper arm and abdomen of 24 healthy volunteers, twice daily in order to determine the efficacy of the formulation as anti-cellulite and slimming agent for 12 weeks. The hydration, elasticity, trans-epidermal water loss (TEWL), body fat content and circumference measurement of abdomen and upper arm of volunteers were evaluated and monitored at baseline (before application of creams), 2nd, 4th, 8th and 12th weeks of study period to measure the effect produced by the creams. RESULTS: The significant (p<0.05) reduction of fat content of upper arm and abdomen was observed after 4 weeks. The circumference measurement of upper arm was reduced significantly (p<0.05) after 8 weeks application of formulation while circumference measurement of abdomen was reduced after 12 weeks. The TEWL of abdomen values showed a significant (p<0.05) decreased immediately after 2 week of application while the TEWL of arm was reduced significantly (p<0.05) after 4 week. Skin hydration was significantly (p<0.05) increased by both creams immediately after 2 week of application. However, there was no changes was observed in skin elasticity for both creams over 12 week period study. CONCLUSION: The formulation containing caffeine was able to improve sign of cellulite, reduced circumference measurement, fat content and TEWL as well increased hydration of skin. 2018-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/68767/1/PRCO10.pdf application/pdf en http://irep.iium.edu.my/68767/2/slide%20iprc%20HAKIMAH%20iium.pdf application/pdf en http://irep.iium.edu.my/68767/23/4IPRC.pdf Mohamad, Nor Hakimah and Ab. Hadi, Hazrina and Doolaanea, Abd Almonem (2018) Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Mohamad, Nor Hakimah Ab. Hadi, Hazrina Doolaanea, Abd Almonem Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
description	INTRODUCTION: Cellulite or lipodystrophy is a major aesthetical concern among women who want to look beautiful. OBJECTIVES: The aim of this study was to evaluate the effectiveness of a topical slimming and anti-cellulite cream containing caffeine on treatment of cellulite and other various skin parameters on human volunteers. METHODS: Placebo and formulation containing 2.5% of caffeine were prepared and applied to the upper arm and abdomen of 24 healthy volunteers, twice daily in order to determine the efficacy of the formulation as anti-cellulite and slimming agent for 12 weeks. The hydration, elasticity, trans-epidermal water loss (TEWL), body fat content and circumference measurement of abdomen and upper arm of volunteers were evaluated and monitored at baseline (before application of creams), 2nd, 4th, 8th and 12th weeks of study period to measure the effect produced by the creams. RESULTS: The significant (p<0.05) reduction of fat content of upper arm and abdomen was observed after 4 weeks. The circumference measurement of upper arm was reduced significantly (p<0.05) after 8 weeks application of formulation while circumference measurement of abdomen was reduced after 12 weeks. The TEWL of abdomen values showed a significant (p<0.05) decreased immediately after 2 week of application while the TEWL of arm was reduced significantly (p<0.05) after 4 week. Skin hydration was significantly (p<0.05) increased by both creams immediately after 2 week of application. However, there was no changes was observed in skin elasticity for both creams over 12 week period study. CONCLUSION: The formulation containing caffeine was able to improve sign of cellulite, reduced circumference measurement, fat content and TEWL as well increased hydration of skin.
format	Conference or Workshop Item
author	Mohamad, Nor Hakimah Ab. Hadi, Hazrina Doolaanea, Abd Almonem
author_facet	Mohamad, Nor Hakimah Ab. Hadi, Hazrina Doolaanea, Abd Almonem
author_sort	Mohamad, Nor Hakimah
title	Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
title_short	Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
title_full	Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
title_fullStr	Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
title_full_unstemmed	Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
title_sort	evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study
publishDate	2018
url	http://irep.iium.edu.my/68767/ http://irep.iium.edu.my/68767/1/PRCO10.pdf http://irep.iium.edu.my/68767/2/slide%20iprc%20HAKIMAH%20iium.pdf http://irep.iium.edu.my/68767/23/4IPRC.pdf
first_indexed	2023-09-18T21:37:33Z
last_indexed	2023-09-18T21:37:33Z
_version_	1777412922429931520

Evaluation of the efficacy of a topical slimming and anti-cellulite cream containing caffeine in vivo study

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