Taste masking efficacy of paracetamol alginate beads

Many pharmaceutical drugs have unpleasant tastes, most of them being bitter. The problems of bitterness of drugs create a serious challenge to pharmacist especially when the drugs need to be taken by paediatric patients. Paracetamol is one of the common medicines that have a bitter taste. Due to thi...

Full description

Bibliographic Details
Main Authors:	Hamed Almuris, Samah, Doolaanea, Abd Almonem
Format:	Conference or Workshop Item
Language:	English English English
Published:	2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/68610/ http://irep.iium.edu.my/68610/1/abstract%20oral%20confernce.pdf http://irep.iium.edu.my/68610/7/4IPRC.pdf http://irep.iium.edu.my/68610/12/conference%20presentation.pdf

id	iium-68610
recordtype	eprints
spelling	iium-686102018-12-19T01:07:13Z http://irep.iium.edu.my/68610/ Taste masking efficacy of paracetamol alginate beads Hamed Almuris, Samah Doolaanea, Abd Almonem RS Pharmacy and materia medica Many pharmaceutical drugs have unpleasant tastes, most of them being bitter. The problems of bitterness of drugs create a serious challenge to pharmacist especially when the drugs need to be taken by paediatric patients. Paracetamol is one of the common medicines that have a bitter taste. Due to this, taste masking becomes one of the important steps during formulation. Therefore, this study aims to develop a paediatric dosage form of paracetamol through using microencapsulation technique. It is a coating technique that provides a physical barrier around the drug to avoid the drug dissolution into the mouth while keeping the drug bioavailability unchanged. The biopolymer alginate is considered as a good choice for microencapsulation purpose. Alginate is a natural polysaccharide polymer isolated from brown seaweed. There is an increase interest toward the use of alginate gel in the form of beads due to non-toxicity of alginate and their ability to encapsulate drugs under very mild conditions without using high temperatures. Alginate gel beads are prepared by drop-wise of sodium alginate solution into a solution containing divalent metal ion such as calcium ion that leads to the formation of a unique egg box-like gel structure. Furthermore, extra coating of paracetamol-alginate beads with chitosan was increase more taste masking properties. Chitosan is a polysaccharide derived from chitin by alkaline deacetylation. The term of chitosan is used to describe a series of chitosan polymers with different molecular weight, viscosity and degree of acetylation. Chitosan is insoluble in at neutral and alkaline pH values but forms salt with inorganic and organic acid. in-vitro dissolution testing was used to evaluate taste masking capability, by quantifying release in simulated oral cavity conditions. From in-vitro studies, it can be concluded that the paracetamol alginate beads able to mask the bitter taste of paracetamol. 2018-08-25 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/68610/1/abstract%20oral%20confernce.pdf application/pdf en http://irep.iium.edu.my/68610/7/4IPRC.pdf application/pdf en http://irep.iium.edu.my/68610/12/conference%20presentation.pdf Hamed Almuris, Samah and Doolaanea, Abd Almonem (2018) Taste masking efficacy of paracetamol alginate beads. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Hamed Almuris, Samah Doolaanea, Abd Almonem Taste masking efficacy of paracetamol alginate beads
description	Many pharmaceutical drugs have unpleasant tastes, most of them being bitter. The problems of bitterness of drugs create a serious challenge to pharmacist especially when the drugs need to be taken by paediatric patients. Paracetamol is one of the common medicines that have a bitter taste. Due to this, taste masking becomes one of the important steps during formulation. Therefore, this study aims to develop a paediatric dosage form of paracetamol through using microencapsulation technique. It is a coating technique that provides a physical barrier around the drug to avoid the drug dissolution into the mouth while keeping the drug bioavailability unchanged. The biopolymer alginate is considered as a good choice for microencapsulation purpose. Alginate is a natural polysaccharide polymer isolated from brown seaweed. There is an increase interest toward the use of alginate gel in the form of beads due to non-toxicity of alginate and their ability to encapsulate drugs under very mild conditions without using high temperatures. Alginate gel beads are prepared by drop-wise of sodium alginate solution into a solution containing divalent metal ion such as calcium ion that leads to the formation of a unique egg box-like gel structure. Furthermore, extra coating of paracetamol-alginate beads with chitosan was increase more taste masking properties. Chitosan is a polysaccharide derived from chitin by alkaline deacetylation. The term of chitosan is used to describe a series of chitosan polymers with different molecular weight, viscosity and degree of acetylation. Chitosan is insoluble in at neutral and alkaline pH values but forms salt with inorganic and organic acid. in-vitro dissolution testing was used to evaluate taste masking capability, by quantifying release in simulated oral cavity conditions. From in-vitro studies, it can be concluded that the paracetamol alginate beads able to mask the bitter taste of paracetamol.
format	Conference or Workshop Item
author	Hamed Almuris, Samah Doolaanea, Abd Almonem
author_facet	Hamed Almuris, Samah Doolaanea, Abd Almonem
author_sort	Hamed Almuris, Samah
title	Taste masking efficacy of paracetamol alginate beads
title_short	Taste masking efficacy of paracetamol alginate beads
title_full	Taste masking efficacy of paracetamol alginate beads
title_fullStr	Taste masking efficacy of paracetamol alginate beads
title_full_unstemmed	Taste masking efficacy of paracetamol alginate beads
title_sort	taste masking efficacy of paracetamol alginate beads
publishDate	2018
url	http://irep.iium.edu.my/68610/ http://irep.iium.edu.my/68610/1/abstract%20oral%20confernce.pdf http://irep.iium.edu.my/68610/7/4IPRC.pdf http://irep.iium.edu.my/68610/12/conference%20presentation.pdf
first_indexed	2023-09-18T21:37:22Z
last_indexed	2023-09-18T21:37:22Z
_version_	1777412910396473344

Taste masking efficacy of paracetamol alginate beads

Similar Items