In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to s...

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Main Authors:	Azad, Abul Kalam, Laboni, Farhina Rahman, Rashid, Harun, Ferdosh, Sahena, Rashid, Shah Samiur, Kamal, Nurkhalida, Labu, Zubair Khalid, Islam, M. S., Sarker, Md. Zaidul Islam
Format:	Article
Language:	English English
Published:	Taylor and Francis Ltd. 2018
Subjects:	RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/1/Cuscuta.pdf http://irep.iium.edu.my/68498/7/68498_In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb_SCOPUS%20inpress.pdf

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spelling	iium-684982019-01-07T07:13:51Z http://irep.iium.edu.my/68498/ In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83lg/mL while the standard ascorbic acid was 2.48mg/ mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p>0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50mg of GAE/g). Taylor and Francis Ltd. 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68498/1/Cuscuta.pdf application/pdf en http://irep.iium.edu.my/68498/7/68498_In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb_SCOPUS%20inpress.pdf Azad, Abul Kalam and Laboni, Farhina Rahman and Rashid, Harun and Ferdosh, Sahena and Rashid, Shah Samiur and Kamal, Nurkhalida and Labu, Zubair Khalid and Islam, M. S. and Sarker, Md. Zaidul Islam (2018) In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities. Natural Product Research. ISSN 14786419 (In Press) https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1538216?journalCode=gnpl20 10.1080/14786419.2018.1538216
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
description	The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83lg/mL while the standard ascorbic acid was 2.48mg/ mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p>0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50mg of GAE/g).
format	Article
author	Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam
author_facet	Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam
author_sort	Azad, Abul Kalam
title	In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
title_short	In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
title_full	In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
title_fullStr	In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
title_full_unstemmed	In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
title_sort	in vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
publisher	Taylor and Francis Ltd.
publishDate	2018
url	http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/1/Cuscuta.pdf http://irep.iium.edu.my/68498/7/68498_In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb_SCOPUS%20inpress.pdf
first_indexed	2023-09-18T21:37:13Z
last_indexed	2023-09-18T21:37:13Z
_version_	1777412900984455168

In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

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